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This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.
Nonstandard methods of analysis consist generally in comparative study of two interpretations of a mathematical claim or construction given as a formal symbolic expression by means of two different set-theoretic models: one, a "standard" model and the other, a "nonstandard" model. The second half of the twentieth century is a period of significant progress in these methods and their rapid development in a few directions. The first of the latter appears often under the name coined by its inventor, A. Robinson. This memorable but slightly presumptuous and defiant term, non standard analysis, often swaps places with the term Robinsonian or classical non standard analysis. The characteristic feature of Robinsonian analysis is a frequent usage of many controversial concepts appealing to the actual infinitely small and infinitely large quantities that have resided happily in natural sciences from ancient times but were strictly forbidden in modern mathematics for many decades. The present-day achievements revive the forgotten term infinitesimal analysis which reminds us expressively of the heroic bygones of Calculus. Infinitesimal analysis expands rapidly, bringing about radical reconsideration of the general conceptual system of mathematics. The principal reasons for this progress are twofold. Firstly, infinitesimal analysis provides us with a novel under standing for the method of indivisibles rooted deeply in the mathematical classics.
The Protected Vista draws a historical lineage from the eighteenth-century picturesque to present-day planning policy, highlighting how the values embedded within familiar views have developed over time through appropriation by diverse groups for cultural and political purposes. The book examines the intellectual construction of the protected vista, questioning the values entrenched within the view, by whom, and how they are observed and disseminated, to reveal how these views have been, and continue to be, part of a changing historical and political narrative. With a deeper knowledge and understanding of the shifting values in urban views, we will be better equipped to make decisions surrounding their protection in our urban centres. The book identifies the origins of current view protection policy in the aesthetic convention of the picturesque, drawing on a range of illustrated examples in the UK, the US, Australia, Canada and South Africa, to serve as a useful reference for students, researchers and academics in architecture, architectural conservation, landscape and urban planning.
The history of pathogens and vectors, unique symptoms of diseases and economic importance of important viral diseases have been dealt with in the introductory chapter of this book. While highlighting the role of arthropods, nematodes, and fungi; other agents of the spread of plant pathogens have also been included. Important aspects of insect vectors with direct bearing on transmission, i.e. vector identification, biology, feeding apparatus, and mechanism of spread including control of pathogens through vectors are covered comprehensively. As aphids and other hemipterous insects are major insect vectors, the book stresses on this order. There is a focus on the transmission of determinants under different categories of the transmission mechanism. The transmission determinant paradigm comprising coat protein and helper component has been expounded with recent cases. A brief description of new diseases at least one from each genus of plant viruses has been included in this compendium to elucidate the interaction of vector and virus. Phytoplasmal etiology of pathogens has been detailed separately on account of their importance. The transmission of plant viruses through insects with biting and chewing type of mouth parts has been discussed in detail as separate chapter. The latest research in the field of mites, nematodes, and fungi as vectors of plant viruses has been included. How the phytotoxemia is different from other crop disorders, has been critically explained with support from suitable and common examples of crop disorders. The book also highlights the effects of plant viruses on their vectors. An account of classification of plant viruses has also been given for better understanding of subject matter. Likewise, the information on the electron microscope along with its use has been included so as to define the procedure of examining sub-microscopic entities. The latest developments in the management of plant pathogens through vector management have been discussed with special reference to the use of biotechnology, crop protection, and plant resistance. The book will be of value to the teachers and to researchers. It will also be useful for extension workers in managing crop disorders. Students and researchers of entomology, plant pathology, plant protection and virology disciplines will obtain the latest in the field, through this book.
I think the reader will agree that we have attained a good balance in Volume 6 between human-or animal-host and plant-host-related topics from outstanding research scientists. In Chapter 1, Frank Collins, Susan Paskewitz, and Victoria Finnerty explore the potential of recombinant DNA technology to distinguish indi vidual species and to establish phylogenetic relationships among member species in the Anopheles gambiae species complex, which includes the principal malaria vectors. Currently, relatively little is known about these morphologically identical species that are sympatric over most of their range but are not always equally involved in malaria transmission. With respect to individual species identification, the researchers have thus far described two DNA fragments, derived from the ribosomal DNA interge nic spacer region, that reliably distinguish five species in the complex by means of an RFLP visualized on a Southern blot. They have also described other species-specific fragments derived from a ribosomal DNA intron that could form the basis for a rapid dot blot assay. With respect to the phylogenetic relationships among member species in the complex, Collins, Paskewitz, and Finnerty focus on a comparison at the level of restriction site mapping and Southern analysis of the rDNA intergenic spacer regions. As expected, the two spacer regions near the coding region junctions are well conserved among the species, whereas the central regions tend to be highly variable among member species in the complex.
Maximum PC is the magazine that every computer fanatic, PC gamer or content creator must read. Each and every issue is packed with punishing product reviews, insightful and innovative how-to stories and the illuminating technical articles that enthusiasts crave.
Maximum PC is the magazine that every computer fanatic, PC gamer or content creator must read. Each and every issue is packed with punishing product reviews, insightful and innovative how-to stories and the illuminating technical articles that enthusiasts crave.