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This treatise had its origins in the authors' strong opinion that the discovery of new drugs, especially of innovative therapeutic agents, really does not happen as a spontaneous sequel to investiga tive research, no matter how penetrating such research may be. Rather, it seemed to us that the discovery of innovative therapeutic agents was a very active process, existing in and of itself, and demanding full attention-it was not simply a passive, dependent by-process of investigative research. And yet, many researchers some close confreres of the authors, others more distant-believed otherwise. We felt that their view reflected unrealistic thinking and that reality probably lay closer to what Beyer" maintained: We are taught to believe that if we can understand a disease it should be easy enough to figure out, say, the molecular configuration of a definitive receptor mechanism somewhere along the line and to design a specific drug . . . . And so we start out to understand the disease but never get around to doing much about therapy. The authors very soon realized that there was essentially no quantitive information available on just where and how innovative therapeutic agents were discovered. There were only anecdotal accounts, and these were able to be selected and presented in ways that could be used to defend any point of view.
The first text on molecular diagnostics specifically designed for clinical laboratory science programs is back! This exceptional resource introduces the fundamentals of nucleic acid, as well as more advanced concepts. With a focus on the application of molecular concepts in the clinical laboratory to diagnosis diseases, the 2nd Edition includes important updates and improvements to keep up with the rapidly developing field. Inside youll find in-depth explanations of the principles of molecular-based assays as well as reference material, trouble-shooting tips for the laboratory, and discussions that emphasize the continuing emergence of new diagnostic technologies.
Non-idiopathic early onset scoliosis represents a true challenge to the physician due to the significance of the ongoing growth of the spine, the risk of curve progression, and the risk of pulmonary insufficiency. A comprehensive review of the growth mechanisms of spine in infancy forms the basis of the book. Clinical evaluation and imaging of early onset scoliosis contribute to the diagnostic overview. The main causes of non-idiopathic early onset scoliosis are briefly described in the second part of the book. The last group of chapters presents the conservative and surgical treatments that are available along with their results, chances and challenges. This comprehensive guide is an opportunity for every specialist involved in the treatment of these severe deformities, to obtain an update of the actual trends and knowledge in the field in a one-point reference.
“An outstanding debut...If you’re a fan of Jack Reacher or Lisbeth Salander, you are gonna love Nikki Griffin.” —New York Times bestselling author Douglas Preston “Action packed and razor sharp - Jack Reacher would love Nikki Griffin.” —Lee Child, #1 New York Times bestselling author of Past Tense Nikki Griffin isn't your typical private investigator. In her office above her bookstore’s shelves and stacks, where she luxuriates in books and the comfort they provide, she also tracks certain men. Dangerous men. Men who have hurt the women they claim to love. And Nikki likes to teach those men a lesson, to teach them what it feels like to be hurt and helpless, so she can be sure that their victims are safe from them forever. When a regular PI job tailing Karen, a tech company's disgruntled employee who might be selling secrets, turns ugly and Karen's life is threatened, Nikki has to break cover and intervene. Karen tells Nikki that there are people after her. Dangerous men. She says she'll tell Nikki what's really going on. But then something goes wrong, and suddenly Nikki is no longer just solving a case—she's trying hard to stay alive. Part Lisbeth Salander, part Jack Reacher, part Jessica Jones, Nikki Griffin is a kickass character who readers will root for as she seeks to right the world's wrongs. S.A. Lelchuk’s Save Me From Dangerous Men marks the beginning of a gripping new series and the launch of a fabulous new character.