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First multi-year cumulation covers six years: 1965-70.
First multi-year cumulation covers six years: 1965-70.
Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. - Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas - Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications - Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs
This book is intended as a Festschrift to honour the work of David Banks, Emeritus Professor of the Université de Bretagne Occidentale, France. The founder and former President of the Association Française de Linguistique Systémique Fonctionnelle, David Banks has been extremely active in bringing together linguists from different theoretical backgrounds in the study of both English and French. The volume includes papers in the three main fields in which he has published: namely, scientific writing, language change and systemic functional linguistics (SFL).
In the autumn of 1971 F. Hoffmann-La Roche & Co. Ltd in Basel celebrated their 75th anniversary. The company was one of the first in the chemical industry to concentrate from the beginning on pharmaceuticals. Step by step new activi ties were taken up, but all within the frontiers of biology. During the 75 years of Roche the research division has become by far the largest department in the company, with basic research assuming an increasingly important part in it. For this reason Roche cannot but feel a share of res pons i bility towards the many problems raised by biomedical progress. Hence, the idea of celebrating the anniversary along conventional lines could not be seriously entertained. The occasion was to show Roche at work. A special kind of work certainly, breaking away from the daily routine into the sphere offree communi cation with thinking people outside the purview of the company's usual tasks.