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Three-time Hugo Award–winning author Allen Steele imagines an alternate history rooted in an actual historical possibility: What if the race to space had occurred in the early days of World War II? It’s 1941, and Wernher von Braun is ordered by his fuhrer to abandon the V-2 rocket and turn German resources in a daring new direction: construction of a manned orbital spacecraft capable of attacking the United States. When the top secret plan is leaked to Franklin Roosevelt, the president has only one logical response: The United States must build their own spacecraft to destroy it. Robert Goddard, inventor of the liquid-fuel rocket, agrees to head the classified project. So begins a race against time between two secret military programs and two brilliant scientists whose high-stakes competition will spiral into a deadly game of political intrigue and unforeseen catastrophes played to the death in the brutal skies above America.
International bestseller David Baldacci pens the stunning conclusion to Cahills vs. Vespers! It started with a kidnapping. A shadowy organization known only as the Vespers snatched seven members of the Cahill family and demanded a series of bizarre ransoms from around the world. Thirteen-year-old Dan Cahill and his older sister, Amy, began a global treasure hunt, determined to bring back whatever Vesper One needed, so long as it kept the hostages safe.But when they deliver the last ransom, Amy and Dan discover Vesper One's terrifying endgame. The objects he demanded are vital pieces in a Vesper plot that will harm millions of innocent people. Now the two siblings and their friends are in an all-out sprint to stop Vesper One . . . before the whole world goes BOOM.
They All Saw A Cat — New York Times bestseller and 2017 Caldecott Medal and Honor Book The cat walked through the world, with its whiskers, ears, and paws . . . In this glorious celebration of observation, curiosity, and imagination, Brendan Wenzel shows us the many lives of one cat, and how perspective shapes what we see. When you see a cat, what do you see? If you and your child liked The Girl Who Drank the Moon, Finding Winnie, and Radiant Child — you'll love They All Saw A Cat "An ingenious idea, gorgeously realized." —Shelf Awareness, starred review "Both simple and ingenious in concept, Wenzel's book feels like a game changer." —The Huffington Post
NEW YORK TIMES BESTSELLER • NAMED ONE OF THE BEST BOOKS OF THE YEAR by Booklist • Kirkus Reviews Celebrate all the ways love makes us who we are with the romance that Entertainment Weekly calls "wise, wildly unique"--from the bestselling co-author of Nick and Norah's Infinite Playlist--about a teen who wakes up every morning in a different body, living a different life. Now a major motion picture! Every day a different body. Every day a different life. Every day in love with the same girl. There’s never any warning about where it will be or who it will be. A has made peace with that, even established guidelines by which to live: Never get too attached. Avoid being noticed. Do not interfere. It’s all fine until the morning that A wakes up in the body of Justin and meets Justin’s girlfriend, Rhiannon. From that moment, the rules by which A has been living no longer apply. Because finally A has found someone he wants to be with—day in, day out, day after day. With his new novel, David Levithan, bestselling co-author of Will Grayson, Will Grayson, and Nick and Norah's Infinite Playlist, has pushed himself to new creative heights. He has written a captivating story that will fascinate readers as they begin to comprehend the complexities of life and love in A’s world, as A and Rhiannon seek to discover if you can truly love someone who is destined to change every day. “A story that is always alluring, oftentimes humorous and much like love itself— splendorous.” —Los Angeles Times
Acute-on-chronic liver failure (ACLF) is a fatal disease that develops in the basis of chronic liver diseases due to acute precipitating events. The lack of definite therapies for ACLF other than liver transplantation urges us to investigate its pathophysiological mechanism. It has been recognized that systemic inflammation is a major driver of ACLF. Although the link between systemic inflammation and organ failure has been established, less is known about how systemic inflammation forms and how it impacts on the organ functions. On the other hand, immunosuppression is another facet of immune derangement of ACLF, which leads to secondary bacterial infections and worsens the situation. However, so far, we know very little on the development of immunosuppression during ACLF and its molecular mechanisms. Thus, this disease is still a big challenge to both clinicians and researchers. The immune derangement of ACLF is characterized by systemic inflammation and immunosuppression. Therefore, one aspect of this Research Topics is to define the concept of systemic inflammation in the context of ACLF. We should clarify the anatomy of systemic inflammation, including the inducers (DAMP and PAMP), immune cells, cytokines and other elements, and their specific roles. We should also investigate how systemic inflammation impacts on organ function and thereby precipitates the development of organ failure. The other aspect of this Research Topic is to delineate immunosuppression in ACLF. Likewise, we need to define immunosuppression by elucidating its causative mechanisms and uncover the specific stage of ACLF at which immunosuppression occurs. Besides, it is essential to further evaluate the impact of immunosuppression on the progression of ACLF. The investigation at these two facets of immune derangement of ACLF will lead to the discovery of biomarkers and potential therapeutical targets.
Recounts the events of a day when everything goes wrong for Alexander. Suggested level: junior, primary.
This book presents a compilation of research findings and conceptualizations in the area of infancy. It is a well-known fact that research in the area of "Infancy" in our country is still in infant stage. Hence, the author made a humble effort to compile the research findings, factually oriented review of literature, and discussions in the diverse areas of the infant development. It is believed that "Infant Development" will add a great deal of information to existing literature in this field. This book is a valuable source for all those specializing in Medicine, Paramedical science, Psychology, Home science, Sociology, Social work, Anthropology as well as for Policymakers and Parents.
This book is for livestock and poultry farmers, students, county agents, energy advisors, and others interested in biogas. It is designed for people with a basic knowledge of farm operations. The purpose is to provide an understanding of how biogas can be produced and used, and to set a frame of reference for assessing the operations that make sense for giogas production. This material is not intended as a system design or operations guide, however. Professional help is advised for planning and designing individual applications.