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In this issue of Veterinary Clinics of North America: Equine Practice, guest editor Ds. Lauren V. Schnabel brings her considerable expertise to the topic of Use of Biologic and Regenerative Therapies in Equine Practice. Top experts in the field explain what the main biologic and regenerative therapies are, what they contain, evidence to date for how they should be used, and how to monitor response to treatment. While the majority of the issue will focus on musculoskeletal applications, other indications for use will be discussed including wounds and ophthalmologic conditions as well as other inflammatory diseases. - Contains 13 practice-oriented topics including equine bone marrow aspirate concentrate; equine stem cells: sources, practices, and potential safety concerns; advances in imaging techniques to guide therapies and monitor response to the treatment of musculoskeletal injuries; use of biologics and stem cells for wound healing in the horse; antimicrobial properties of equine stem cells and platelets; and more. - Provides in-depth clinical reviews on the use of biologic and regenerative therapies in equine practice, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
In this issue of Veterinary Clinics of North America: Equine Practice, guest editor Ds. Lauren V. Schnabel brings her considerable expertise to the topic of Use of Biologic and Regenerative Therapies in Equine Practice. Top experts in the field explain what the main biologic and regenerative therapies are, what they contain, evidence to date for how they should be used, and how to monitor response to treatment. While the majority of the issue will focus on musculoskeletal applications, other indications for use will be discussed including wounds and ophthalmologic conditions as well as other inflammatory diseases. Contains 13 practice-oriented topics including equine bone marrow aspirate concentrate; equine stem cells: sources, practices, and potential safety concerns; advances in imaging techniques to guide therapies and monitor response to the treatment of musculoskeletal injuries; use of biologics and stem cells for wound healing in the horse; antimicrobial properties of equine stem cells and platelets; and more. Provides in-depth clinical reviews on the use of biologic and regenerative therapies in equine practice, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Dr. McIlwraith's Joint Disease in the Horse, 2nd Edition is the only book to give you a full account of equine joint disease, combining a thorough, up-to-date survey of scientific advances with a practical guide to both medical and surgical treatments. With contributions from nationally and internationally recognized pioneers in the field, this groundbreaking text offers an overview of joint structure and function and translates the latest information on basic joint pathobiology into practical application for the clinician. Step-by-step guidance on injection techniques and medications, along with a survey of practical arthroscopic surgery and developments, make it a truly indispensable reference for all equine veterinarians treating sports and racing horses. UNIQUE! Unprecedented, state-of-the-art coverage of the pathology, pathogenesis, and clinical diagnosis of traumatic and degenerative joint disease, so you stay in the know. Section on general principles of joint pathobiology provides the background to evaluate and interpret the diagnostic and surgical aspects of disease. Explores treatments for traumatic arthritis and osteoarthritis and other joint entities, offering a broad range of options and up-to-date recommendations for problematic decisions. Addresses recent advances and results in arthroscopic surgery for the acute injury and results including fragment removal, fragment fixation, and synovectomy. Discussion of current research provides insight for difficult cases and calls out the directions in which future arthritis research is headed. More than 325 photographs and line drawings help engage and guide you through procedures and treatments. NEW! Full color throughout with new artwork and a range of new images including radiographs showing both the normal and the disease progression. NEW! Practical step-by-step approach demonstrates the authors' preferred injections methods and shows underlying anatomic correlations. NEW and UPDATED! Restructured and substantially revised to emphasize treatment options, making it a practical, concise, and accessible reference and text. NEW! All-new chapters on drugs and new biological therapies, including stem cells, IRAP, and PRP and thoroughly updated coverage of HA and corticosteroids. NEW! Covers advanced imaging, giving you the latest information available. NEW! Expert advice from Dr. McIlwraith, three new co-editors, and new contributors - all distinguished specialists in the field of joint disease in the horse. Lameness and surgical clinicians describe how to approach the various, specific disease conditions. Equine specific radiologists provide their opinions on the best imaging techniques for defining the disease and making interpretations.
This book focuses on mesenchymal stem cells (MSCs) of animal origin, including their isolation, characterization, and clinical applications. After briefly discussing the historical development of the field of stem cell research, it describes the basic properties and nature of stem cells particularly in relation to MSCs. In turn, it reviews materials and methods used to isolate MSCs from various sources, culture expansion, characterization and long-term storage. It also explores the therapeutic efficacy, immunomodulation and anti-inflammatory, and differentiation properties of MSCs. Importantly, the book discusses the applications of genetic engineering to enhance the efficacy and potential of MSCs in regenerative medicine. The book largely addresses the potential applications of mesenchymal stem cells in therapies for important species of domesticated animals including sheep, goats, cattle, buffalo, cats, dogs and horses. Finally, the book presents an abridgement of challenges and future prospects of stem cell research and application in medicine, in general and veterinary sciences, in particular.
The most comprehensive text available on equine surgery, this book prepares the veterinary surgeon for managing each surgical condition by understanding its pathophysiology and evaluating alternative surgical approaches. Explanations describe how to avoid surgical infections, select and use instruments, and perfect fundamental surgical techniques including incisions, cautery, retractions, irrigation, surgical suction, wound closure, dressings, bandages, and casts. Thorough and complete coverage means this is the only book practitioners and students need. World-renowned contributors include 67 of the most experienced and expert equine practitioners, each providing current and accurate information. This text covers all the information needed to study for the American and European College of Veterinary Surgeons Board Examination, making it an excellent study tool. Coverage of anesthesiology and pain management is reintroduced in this edition. Extensive and up-to-date orthopedic coverage includes joint disorders and joint trauma. Integumentary system coverage includes wound management, reconstructive surgery, and skin grafting. Other important topics include the alimentary system, cardiovascular surgery, and new techniques in vascular surgery. More minimally invasive surgical techniques A section on anesthesia has been re-introduced to this edition
This book discusses the different regulatory pathways for gene therapy (GT) and cell therapy (CT) medicinal products implemented by national and international bodies throughout the world (e.g. North and South America, Europe, and Asia). Each chapter, authored by experts from various regulatory bodies throughout the international community, walks the reader through the applications of nonclinical research to translational clinical research to licensure for these innovative products. More specifically, each chapter offers insights into fundamental considerations that are essential for developers of CT and GT products, in the areas of product manufacturing, pharmacology and toxicology, and clinical trial design, as well as pertinent "must-know" guidelines and regulations. Regulatory Aspects of Gene Therapy and Cell Therapy Products: A Global Perspective is part of the American Society of Gene and Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals.
Complications in Equine Surgery is the first reference to focus exclusively on understanding, preventing, recognizing, managing, and prognosing, technical and post-procedural complications in equine surgery. Edited by two noted experts on the topic, the book presents evidence-based information using a clear approach, organized by body system. Featuring color images, the book contains detailed coverage of the gastrointestinal, respiratory, musculoskeletal, urogenital, and neurological systems. Each chapter contains a short introduction of the procedure with explanations of when and how the procedure is to be performed. All chapters review how to recognize and prevent technical complications and explain how to manage post-operative complications. This important text: Offers the first resource specifically focused on complications encountered in equine surgery Takes a helpful format organized by body system Provides consistently formatted chapters for ease of use Covers clinically relevant information for dealing with technical and post-operative complications Presents more than 350 color images to illustrate the concepts described Written for general practitioners and specialists, Complications in Equine Surgery is an essential resource to decreasing morbidity and mortality and increasing surgical success in horses.
The Third Edition of this classic surgery text is the ideal resource for veterinary students and equine and mixed large animal practitioners. The book can be used both as an introduction to the fundamental techniques of large animal surgery and as an easy-to-use guide for quick reference in the field. The step-by-step technique sections have been restructured to allow faster access to information, including objectives and lists of equipment needed for each procedure. In addition to general updates throughout, this edition features new sections on minimally invasive surgery, laser surgery, and laparotomy. Coverage includes surgical techniques for horses, cows, pigs, goats, and select exotic species. Most techniques presented can be performed without the advantages of a fully equipped large animal hospital or teaching institution.
Equine Clinical Pathology is the first complete resource for hematology and clinical chemistry in horses. Encompassing the basic principles and advanced interpretation, the book’s single-species approach to pathology allows for focused coverage of the unique disease characteristics of equids. Equine Clinical Pathology is equally useful for anyone using clinical pathology as a diagnostic tool, from beginning student to experienced specialist. The heart of the book is organized by body system, making it easy to find and apply information. Chapters cover general laboratory medicine, including instruments and techniques, hematology, and proteins as well as specific organs, such as the kidney and liver. Equine Clinical Pathology is a useful bench-side reference for anyone involved in laboratory medicine for the horse.