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The new edition of this popular, well-established textbook addresses the expanding role of the pharmacist in treating patients. It covers treatment of common diseases as well as other medical, therapeutic and patient related issues. Written by both pharmacists and clinicians to reflect a team approach, it offers an in-depth analysis of drug therapy in the treatment of disease, relying on input from the pharmacist as a member of the "team" in hospital and community settings. Information is easy to locate in a logical format organized primarily by systems and disorders.
Whether you are interpreting the medical literature to optimize patient care, improve health outcomes, or generate hypothesis for research, an understanding of biostatistics is essential for success. Despite exposure to biostatistics in undergraduate and professional education, pharmacists tend to be less confident in their knowledge of biostatistics and their ability to interpret the medical literature than in their clinical skills. This book was developed to bolster the pharmacist's knowledge and confidence for using biostatistical tools for interpreting the literature. With material drawn from ACCP's renowned Pharmacotherapy Self-Assessment Program (PSAP) and the live pharmacotherapy preparatory course Updates in Therapeutics, editor Robert DiCenzo, Pharm.D., FCCP, BCPS, has designed this review to support pharmacists' preparation for the Pharmacotherapy and Ambulatory Care Board of Pharmacy Specialties (BPS) examinations.
This book covers all the pharmacology you need, from basic science pharmacology and pathophysiology, through to clinical pharmacology to therapeutics, in line with the integrated approach of new medical curricula. The first section covers the basic principles, and the rest is organised by body systems. The book ends with sections on toxicity and prescribing practice. Integrates basic science pharmacology, clinical pharmacology and therapeutics Brief review of pathophysiology of major diseases Case histories and multiple choice questions (and answers) Tabular presentation of all common drugs within each class Section on further reading Kinetics chapter simplified with more practical examples Includes more on genetic issues Drug tables made more concise to make information more accessible Fully updated to reflect current clinical practice
Critical Care Pharmacotherapeutics presents information on the fundamentals of critical care practice from a pharmacist's point of view. This accessible text is an excellent introduction to critical care pharmacy. Pharmacy students, residents, and new pharmacists will learn about the medications used and approaches to pharmaceutical care for the critically ill patient. This text is also a helpful reference for students during an ICU advanced practice experience or for a pharmacy resident during an ICU rotation.
- ALL-NEW topics provide updates on infectious diseases, including herpesvirus, equine granulocytic anaplasmosis, and lawsonia infection and proliferative enteropathy; pain diagnosis and multimodal management; management of thoracic and airway trauma, imaging, endoscopy, and other diagnostic procedures for the acute abdomen; and neurologic injury. - 212 concise, NEW chapters include both a succinct guide to diagnosis of disorders and a detailed discussion of therapy. - NEW images demonstrate advances in various imaging techniques. - Thoroughly updated drug appendices, including all-new coverage of drug dosages for donkeys and mules, provide a handy, quick reference for the clinical setting.
This casebook is designed to help students develop the skills required to identify and resolve drug therapy problems through the use of patient case studies.
Everything you need to pass the NAPLEX® – comprehensive study material and two practice exams – in one student-reviewed package Written by an instructor who has taught thousand of students, this all-in-one study guide was developed and reviewed by pharmacists, faculty, students, and recent graduates – so you know it contains only the most relevant, up-to-date conent. You’ll find valuable foundational material and chapter-ending case application questions that cover every key topic included on the NAPLEX. Two downloadable practice tests with a total of 370 questions allowing you to pinpoint your weaknesses. Includes: Coverage that is organized around the NABP competencies and designed to sharpen problem-solving skills, put must-know information at your fingertips, and improve exam-taking ability More than 1400 case application questions, each with a detailed explanation of both correct and incorrect answer choices Takeaway Points at the end of every chapter that summarize key concepts Two complete downloadable practice tests, each with 185 questions
The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. - Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships - Integration of knowledge across all areas of antibody engineering, development, and marketing - Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity
Beginning with the structure, types, functions, and gene organization of antibodies, the book aims to shine a detailed light on the monoclonal antibodies (often referred to as mAbs) that have revolutionized the fields of therapeutics and diagnostics. The book describes the different ways of generating chimeric, humanized, and fully human monoclonal antibodies, emphasizing phage display, hybridoma, and rDNA technology. In addition, the book focuses on the various recombinant antibody formats in detail: Drug conjugates: Antibody-drug conjugates (ADCs), Immunotoxins (Recombinant, Humanized and Fully Human) and Antibody-antibiotic conjugate (AAC) Bispecific antibodies: scFv based (BiTE, DARTs and TandAbs) and Full-length IgG based Abzymes and Antibody-directed enzyme prodrug therapy (ADEPT) Fc-fusion proteins Single-domain antibodies (VHH and IgNAR sdAb) The book discusses the various therapeutic applications of monoclonal antibodies, along with the immunogenicity issues. The book also covers the modes of administration and side effects of monoclonal antibodies, along with the challenges and issues faced while developing a monoclonal antibody into a therapeutic agent. Modifications introduced by the researchers to decrease the immunogenicity issues and increase the efficacy of therapeutic mAbs are also described. The book is an invaluable resource for researchers and students in biology and medicine, biotechnology, immunology, genetics, molecular biology, and anyone interested in antibody engineering.