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The word revolution has a number of definitions (The American Heritage Dictionary, 2006). The one most pertinent to this series and volume is 'a sudden or momentous change in a situation'. Recent years have seen an unprecedented explosion of interest in unfolded proteins in all of their various forms. Coupled with this increase in interest we have seen momentous changes in the way unfolded proteins are viewed. Two particular paradigms have come under close scrutiny: unfolded proteins are disordered random coils devoid of persistent structure, and protein function first requires protein structure. The first of these is currently a hotly debated subject. The second paradigm we can safely claim has been overturned. There is a second definition of revolution that is quite relevant to a significant portion of the work reviewed herein, in particular those chapters dealing with local and persistent structure in unfolded proteins. That definition is 'a turning or rotational motion about an axis' (The American Heritage Dictionary, 2006). About four decades ago, Charles Tanford (1968) demonstrated that highly denatured proteins possess hydrodynamic properties consistent with Paul Flory's random coil (Flory, 1969). Given that the Flory random coil definition included the stipulation that conformers making up the denatured state ensemble would differ in energy by just a few kT, there has been the assumption that denatured states must therefore be completely random in nature with no persistent structure or biases towards particular conformers. Notably however, Tanford did note the random coil-like hydrodynamic data he obtained did not necessarily rule out the presence of structure in denatured proteins (Tanford, 1968). Around the same time, Sam Krimm and M. Lois Tiffany noted that the CD spectra they obtained for proteins in the presence of high concentration of chemical denaturants had similarities to spectra obtained for homopolymers of proline, lysine, and glutamic acid in water (Tiffany and Krimm, 1968a, 1968b, 1973, 1974). Homopolymers of these residues were known to adopt the left-handed polyproline II conformation, leading Tiffany and Krimm to hypothesise that highly denatured proteins possess significant polyproline II helix content. Of these two views, that espousing the lack of structure in denatured proteins became more widely adopted and was, over time, adopted as a central paradigm in protein folding. As several of the chapters in this volume note, a Tiffany and Krimm-like view appears to be, to some extent, the more correct one. The level to which it is correct is still unknown, although it is clear that the polyproline II helical conformation is not the only, perhaps not even the most common, persistent conformation present in unfolded proteins. Thus we have come through a full circle or revolution. (from the preface)
Unfolding Practice: Reflections on Learning and Teaching is a conversation between two artist-educators. Flowing across five chapters, the double sided accordion book has been curated from ten years of recorded conversations, field notes, planning, sketches, reflection, and teaching. The front of the book weaves text, illustration, cutouts, and screen prints, journeying through artistic process and educational practice. The back of the book is a guide, expanding on the practice of using accordion books as a tool for capturing, visualizing, and building upon reflective thinking. The brown paper alludes to the craft paper that is ubiquitous in schools and captures process more than the preciousness of a final product.
Folds are currently on the rise at the moment and this book shows how to manipulate and finish them in order to obtain that personal touch so crucial in the world of fashion. Working from the simplest possible form, the book addresses all major dimensional techniques, shows how they are related and give examples of both traditional and modern variations. This book can be considered as an encyclopaedia of folding techniques, explaining step by step the world of folds and how to apply them in practice. The explanations and diagrams about the different types of pleating are very clear and easy to follow, showing the stages of construction and the finished garments. This title includes an analysis of the use of folds in fashion throughout history and also a helpful tutorial using 30 examples from some of the most innovative and avant- garde designers in fashion today. AUTHOR: Brunella Giannangeli, Venezuelan of Italian origin, studied in the United States, where she graduated as a graphic designer at the Art Institute of Fort Lauderdale. In 2009 she moved to Madrid to study a Masters in Textile and Surfaces Design at the IED Design School. Currently, Brunella lives in London, where she created her own collection of fabrics and prints for various clients in the fashion and interior design sectors. For the realisation of this book Brunella has collaborated with the Spanish dressmaker Maria Molina. fully illustrated in colour
"Masterful" – Ian Dunt "Fascinating" – Professor Brian Cox "Vital" – David Miliband *** Britain's 2016 vote to leave the EU divided the nation, unleashing years of political turmoil. Today, many remain unreconciled to Brexit whilst, in a tragic irony, some of those most committed to it are angry and dissatisfied with what was delivered. In this clear-headed assessment, Chris Grey argues that this painful legacy was all but inevitable, skilfully unpacking how and why the promise of Brexit dissolved during the confusing and often dramatic events that followed the referendum. Now fully updated with an afterword covering each element of the Brexit debate since the end of the transition period in 2021, this new edition remains the essential guide to one of the most bitterly contested issues of our time.
Jonah wishes he could get the girl, but he’s an outcast and she’s the most perfect girl he knows. And their futures seemed destined to fork apart: Jonah’s physical condition is debilitating, and epileptic seizures fill his life with frustration. Whereas Stormi is seemingly carefree, and navigates life by sensing things before they happen. And her most recent premonition is urging her to leave town. When Stormi begs Jonah for help, he finds himself swept into a dark mystery his small town has been keeping for years. And the answers Stormi needs about her own past could possibly destroy everything Jonah has ever known—including his growing relationship with Stormi herself. Advance praise: “Friesen's story unfolds with so much intrigue, swells with so much heart, I had to keep reading. And the writing? Beautiful!” —Jay Asher, author of the #1 New York Times bestselling novel Thirteen Reasons Why “As someone with Tourette Syndrome, I grew up with a condition that others did not understand. It affected the way I was viewed and the way I viewed myself. I applaud Jonathan Friesen for telling a story about overcoming such a challenge in Unfolding. Hopefully, this will inspire others growing up with such conditions as well as help everyone else better understand what is involved.” —Tim Howard, former US national team goaltender and current goalkeeper for the Colorado Rapids
An 8-session Bible study for men exploring the Bible's overarching story of redemption--a story of a God who loves us, longs to be known by us, and ultimately invites us into His story.
Love Indian food but feel it's too daunting to recreate at home? Those complex authentic flavors! Those dozens of spice blends! The long prep time! Fear not. Award-winning cooking teacher Raghavan Iyer puts the breeze and ease into Indian cooking. Taking a heavily illustrated, step-by-step approach, he introduces cooks to one of the world's most popular cuisines. With his natural charm and enthusiasm, Raghavan begins each chapter by explaining the recipe choices, what techniques are included, and a suggested order in which to approach the recipes. The book's 100 authentic recipes use only ingredients readily available at the local supermarket. Taking into account time restraints, each dish can be quickly assembled and will give home cooks the confidence to create knockout Tandoori Chicken, Coconut Squash with Chiles, Turmeric Hash Browns, Saffron-Pistachio Ice Cream Bars, and Mango Bread Pudding with Chai Spices. From basic breads to chutneys and savory pickles, from tasty dal to fragrant basmati rice pilafs, from crispy starters to enjoy with a Slumdog Martini, Indian Cooking Unfolded is a 21st-century approach to one of the most ancient—and popular—cuisines.
First published in 1987. In Unfolding Meaning, the author, one of the most provocative and original thinkers of our time, argues that there are other ways of thinking to bring about a different, more harmonious reality. Our fragmented, mechanistic notion of order derives from the modem conception that our earth is only part, not - as it was with the Greeks - the centre, of the immense universe of material bodies. The implications of this idea permeate modem science and technology today and also our general attitude to life.
God’s love, plans, and promises for you are forever unfolding. I get it, Momma. I totally get it. Every day you wake up and try your very best. You love, give, and pour out your life for the ones who call you Momma. But no matter how much you offer, there are still days you feel as though you come up short. You worry, Am I loving these babies enough? Is this ever going to get easier? Why does it seem like I am the only one who cannot balance it all? Sometimes, we just need hope (and maybe a long uninterrupted nap). We need someone to help tune our hearts to the voice of the Father and to remind us that He has not forgotten about us. In Hope Unfolding, Becky Thompson is a friend who reminds you that you aren’t alone, and that God is still writing your story. She guides you to encounter the Truth of God’s presence that not only fuels you with strength, but also a fresh confidence. And beyond gaining faith that tomorrow could be different, you find hope and purpose where you are standing today.