Download Free Understanding Longevity At Molecular Level A Comprehensive Review Book in PDF and EPUB Free Download. You can read online Understanding Longevity At Molecular Level A Comprehensive Review and write the review.

Understanding “LONGEVITY” at Molecular Level. A Comprehensive Review. The more we learn about aging, the more it seems like it might not be an inescapable consequence of life. A striking fact is that aging rates vary dramatically from one species to the other, and from one individual to the other within one species. Some species age so slow that individuals systematically die of starvation, disease, accident or predation before showing any sign of senescence. It is thus tempting to imagine that a better knowledge of the determinants of lifespan could enable us to delay aging Biological causes of aging and lifespan limitation. The more we learn about aging, the more it seems like it might not be an inescapable consequence of life. A striking fact is that aging rates vary dramatically from one species to the other, and from one individual to the other within one species. Some species age so slow that individuals systematically die of: · starvation, · disease, · accident or · predation before showing any sign of senescence. It is thus tempting to imagine that a better knowledge of the determinants of lifespan could enable us to delay aging. Hence, an effort has been made in this Booklet to describe “Longevity” at Molecular Level comprehensively by including several interesting topics (listed in the Table of Content) along with several relevant illustrations for the enthusiastic/ busy Medicos. …Dr. H. K. Saboowala. M.B.(Bom)M.R.S.H.(London)
Demographers and public health specialists have been surprised by the rapid increases in life expectancy, especially at the oldest ages, that have occurred since the early 1960s. Some scientists are calling into question the idea of a fixed upper limit for the human life span. There is new evidence about the genetic bases for both humans and other species. There are also new theories and models of the role of mutations accumulating over the life span and the possible evolutionary advantages of survival after the reproductive years. This volume deals with such diverse topics as the role of the elderly in other species and among human societies past and present, the contribution of evolutionary theory to our understanding of human longevity and intergenerational transfers, mathematical models for survival, and the potential for collecting genetic material in household surveys. It will be particularly valuable for promoting communication between the social and life sciences.
This book presents a completely novel approach to the understanding of ageing, which many believe is an unsolved problem in biology. It explains why ageing exists in animals, and reviews our understanding of it at the biological level. This includes a discussion of the origins and evolution of ageing. The book is not a review of research on ageing, but instead draws on material from a wide range of disciplines, including the very extensive biomedical information about age-related diseases in humans. Understanding Ageing argues that much research needs to be done on the cellular and molecular aspects of ageing, if the origins of these diseases are to be understood, and their prevention made possible. This thought-provoking book will appeal to all students and researchers who are interested in ageing, whether they are working in the clinical or basic research sphere.
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine.
This is a vital book for those who care about the environment, society and deploying new technology to check the destructive power of humankind.- Allan Thornton, President, Environmental Investigation Agency, Washington, DC., and recipient of the Albert Schweitzer MedalThis book will shake conventional environmental wisdom to its roots. ... A landmark work that should be read by environmentalists and businesspersons alike.- Patrick Moore, cofounder, Greenpeace; president, GreenspiritIn Our Molecular Future [Mulhall] neatly outlines why our increasing ability to manipulate single atoms and molecules is a concern, and lays out the opportunities and threats this technology presents. And it''s surprisingly readable, unlike most of the nanobabble in the science journals. In the end, as Mulhall admits, he poses more questions than he answers. But that''s a good place to start.-New ScientistI just finished reading Douglas Mulhall''s outstanding new book Our Molecular Future . . . and I highly recommend it. Put this one at the top of your list! . . . In an easy to read format, with very few forays into geek-speak, Mulhall presents his well considered and thoroughly researched theories. Overall, an excellent overview for those who wish to understand how disruptive and enabling technologies may save us from ourselves and from mother nature. And along the way you will learn a lot about how nanoscale technologies may enhance our lives, provide abundance for all, and greatly raise the standard of living for everyone. . . . Rating: five stars out of five.- Rocky Rawstern, Nanotech NowWhat Alvin Toffler''s Future Shock was to the 20th century, Our Molecular Future will be to the 21st century.'What will happen to our jobs, health care, and investments when the molecular revolution hits?How might artificial intelligence transform our lives?How can molecular technologies help us cope with climate changes, earthquakes, and other extreme natural threats?Our Molecular Future explores some intriguing possibilities that answer these questions and many others. Douglas Mulhall describes the exponential changes that are about to be wrought by the nanotechnology and robotic revolutions, which promise to reduce the scale of computing to the nanometerùa billionth of a meterùwhile increasing computing power to almost unimaginable levels.The resulting convergence of genetics, robotics, and artificial intelligence may give us hitherto undreamed-of capacities to transform our environment and ourselves. In the not-so-distant future, our world may include machines that scour our arteries to prevent heart disease, cars and clothes that change color at our whim, exotic products built in our own desktop factories, and enhancements to our personal financial security despite greatly accelerated obsolescence.But while technology is making these fantastic leaps, we may also encounter surprises that throw us into disarray: climate changes, earthquakes, or even a seemingly improbable asteroid collision. These extremes are not the nightmare scenarios of sensationalists, Mulhall stresses, nor are many of them human induced. Instead, they may be part of nature''s cycleùrecurring more often than we''ve thought possible.The good news is that this convergence of catastrophe and technological transformation may work to our advantage. If we''re smart, according to Mulhall, we can use molecular machines to protect ourselves from nature''s worst extremes, and harness their potential benefits to usher in an economic renaissance.This visionary link between future technology and past disasters is a valuable guide for every one of us who wants to be prepared for the twenty-first century.Further Praise for OUR MOLECULAR FUTURE:A provocative and profoundly convincing message from the future.- Graham Hancock, archaeological journalist and author of Fingerprints of the GodsIn a breezy, journalistic style, Our Molecular Future takes us on a tour through some of the issues that will preoccupy ma
Food or calorie restriction has been shown in many short-lived animals and the rhesus monkey to prolong life-span. Life-long nutrition studies are not possible in humans because of their long survival. Studies over two to six years in healthy adult humans have, however, shown that a 20% reduction in food or calorie intake slows many indices of normal and disease-related aging. Thus, it is widely believed that long-term reduction in calorie or food intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer, and so prolong life. Over the last 20 or more years there has been a progressive rise in food intake in many countries of the world, accompanied by a rising incidence of obesity. Thus our increasing food and calorie intake has been linked to the rising incidence of cardiovascular disease and diabetes in early adult life. It is accepted that overeating, accompanied by reduced physical exercise, will lead to more age-related diseases and shortening of life-span. The answer is to reduce our calorie intake, improve our diet, and exercise more. But calorie restriction is extremely difficult to maintain for long periods. How then can we solve this problem? Edited by a team of highly distinguished academics, this book provides the latest information on the beneficial effects of calorie restriction on health and life-span. This book brings us closer to an understanding at the molecular, cellular and whole organism level of the way forward.
This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong. Starting with a comprehensive overview of various hypotheses on biological mechanisms of aging by Dr. Sataro Goto, each chapter covers broad aspects of the most recent findings in aging-related topics: centenarian studies and genome analysis of progeria, metabolic biochemistry and neurobiology, longevity controls in yeast and nematodes, oxidative stress and calorie restriction, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s diseases, with further potential therapeutic approaches to these age-related neurodegenerative diseases. Also included, in part, is a summary and the outcomes of a scientific discussion forum called the Asian Aging Core for Longevity (AACL) that has been held annually alternating between Japan and Korea during the last decade. This book can serve as a useful resource for finding appropriate collaborators in the areas it covers. The target readership is made up of graduate students and researchers at universities, medical and/or life-science schools, and biomedical and pharmaceutical institutes. Why does aging exist? How do we age? How is each organism’s lifespan determined? These are fundamental questions in the field. We may be still far from achieving a complete view of aging mechanisms, but this book, Aging Mechanisms, offers an excellent opportunity to become familiar with the most updated progress in the biomedical research of aging in Japan and Korea, the two leading nations for human longevity.