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Due to the ever increasing interest in the use of non-invasive ultrasonic methods in medical diagnostics on the one hand and the specific effects of ultrasound in medical therapy on the other, the questions of safety and optimal applications are topical and of great importance. For this reason the symposium "Ultrasound Interaction in Biology and Medicine," initiated and supported by the "International Organization of Medical Physics," took place. The organizers were the Institute of Applied Biophysics of the Martin-Luther-University, Halle (Saale), German Democratic Republic, in association with the Society for Physical and Mathematical Biology of the GDR along with other scientific organizations. Renowned and internationally noted specialists in the field of ultrasonics reported on the latest findings regarding the biological interaction of ultrasound, which promised future improvements in the methods of ultrasonic diagnostics and gave and up-to-date insight into the biological effectiveness of ultrasound. We are pleased to be able to publish selected contributions to this symposium collected in one volume. The methods of investigation, theoretical considerations and results concerning the interaction of ultrasound on molecular, cellular and system levels contained herein will remain up-to-date for a long time to come, providing thought provoking material for further inter-disciplinary basic research and medical application.
This book provides a thorough yet concise introduction to quantitative radiobiology and radiation physics, particularly the practical and medical application. Beginning with a discussion of the basic science of radiobiology, the book explains the fast processes that initiate damage in irradiated tissue and the kinetic patterns in which such damage is expressed at the cellular level. The final section is presented in a highly practical handbook style and offers application-based discussions in radiation oncology, fractionated radiotherapy, and protracted radiation among others. The text is also supplemented by a Web site.
This volume contains the lectures presented at the International School of Radiation Damage and Protection at the "Ettore Majorana" Centre for Sci entific Culture in Erice, Italy, September 6-15, 1985. The sixth course of the School, entitled "Advances in Applications, Biological Effects, and Dosimetry of Ultrasound," provided an in-depth review of all facets of ultra sound interactions and their biological effects on living systems, allowing an assessment of the hazard potential of the various applications of ultra sound. Particular reference was made to possible health risks associated with medical ultrasound exposure since this use is by far the most prevalent. Since the initial application of ultrasound to submarine detection, medical diagnostic and therapeutic applications have become predominant over the past 20 years. The question of safety of this physical agent is an extremely important one. In many industrialized countries most pregnant women receive at least one diagnostic ultrasound examination before the birth of the child. Thus, potential hazards to the fetus are of prime concern. This problem has been aggravated by the fact that the medical diagnostic applications of ultrasound have far outpaced research efforts on biological effects. A further compounding factor of concern to clinicians and scientists has been the use of higher and higher intensities by the manufacturers of ultrasound equipment, particularly higher peak pulse intensities.
The physical properties of ultrasound, particularly its highly directional beam behaviour, and its complex interactions with human tissues, have led to its becoming a vitally important tool in both investigative and interventional medicine, and one that still has much exciting potential. This new edition of a well-received book treats the phenomenon of ultrasound in the context of medical and biological applications, systematically discussing fundamental physical principles and concepts. Rather than focusing on earlier treatments, based largely on the simplifications of geometrical acoustics, this book examines concepts of wave acoustics, introducing them in the very first chapter. Practical implications of these concepts are explored, first the generation and nature of acoustic fields, and then their formal descriptions and measurement. Real tissues attenuate and scatter ultrasound in ways that have interesting relationships to their physical chemistry, and the book includes coverage of these topics. Physical Principles of Medical Ultrasonics also includes critical accounts and discussions of the wide variety of diagnostic and investigative applications of ultrasound that are now becoming available in medicine and biology. The book also encompasses the biophysics of ultrasound, its practical applications to therapeutic and surgical objectives, and its implications in questions of hazards to both patient and operator.
This book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i.e., high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i.e., tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i.e., chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology.
Diagnostic Ultrasound Imaging provides a unified description of the physical principles of ultrasound imaging, signal processing, systems and measurements. This comprehensive reference is a core resource for both graduate students and engineers in medical ultrasound research and design. With continuing rapid technological development of ultrasound in medical diagnosis, it is a critical subject for biomedical engineers, clinical and healthcare engineers and practitioners, medical physicists, and related professionals in the fields of signal and image processing. The book contains 17 new and updated chapters covering the fundamentals and latest advances in the area, and includes four appendices, 450 figures (60 available in color on the companion website), and almost 1,500 references. In addition to the continual influx of readers entering the field of ultrasound worldwide who need the broad grounding in the core technologies of ultrasound, this book provides those already working in these areas with clear and comprehensive expositions of these key new topics as well as introductions to state-of-the-art innovations in this field. - Enables practicing engineers, students and clinical professionals to understand the essential physics and signal processing techniques behind modern imaging systems as well as introducing the latest developments that will shape medical ultrasound in the future - Suitable for both newcomers and experienced readers, the practical, progressively organized applied approach is supported by hands-on MATLAB® code and worked examples that enable readers to understand the principles underlying diagnostic and therapeutic ultrasound - Covers the new important developments in the use of medical ultrasound: elastography and high-intensity therapeutic ultrasound. Many new developments are comprehensively reviewed and explained, including aberration correction, acoustic measurements, acoustic radiation force imaging, alternate imaging architectures, bioeffects: diagnostic to therapeutic, Fourier transform imaging, multimode imaging, plane wave compounding, research platforms, synthetic aperture, vector Doppler, transient shear wave elastography, ultrafast imaging and Doppler, functional ultrasound and viscoelastic models
Develop the clinical decision-making skills you need to be a successful PTA. This easy-to-follow approach helps you learn how to successfully relate thermal, mechanical, and electrical modalities with specific therapeutic goals while understanding all of the physiologic ramifications