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Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.
Dr. John E. Sarno's groundbreaking research on TMS (Tension Myoneural Syndrome) reveals how stress and other psychological factors can cause back pain-and how you can be pain free without drugs, exercise, or surgery. Dr. Sarno's program has helped thousands of patients find relief from chronic back conditions. In this New York Times bestseller, Dr. Sarno teaches you how to identify stress and other psychological factors that cause back pain and demonstrates how to heal yourself--without drugs, surgery or exercise. Find out: Why self-motivated and successful people are prone to Tension Myoneural Syndrome (TMS) How anxiety and repressed anger trigger muscle spasms How people condition themselves to accept back pain as inevitable With case histories and the results of in-depth mind-body research, Dr. Sarno reveals how you can recognize the emotional roots of your TMS and sever the connections between mental and physical pain...and start recovering from back pain today.
Membranes are essential cellular organelles. They not only define cells and other organelles, but also are critical in the cell function by selectively regulating the passage of molecules by acting as a matrix for other signaling molecules, and as conduits of information transfer between the external environment and the cell interior. This series was originally added in 1970 and has since provided a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include History of Ion Channels in the Pain Sensory System; Historical Overview; TRPV1, a Polymodal Sensor in the Nociceptor Terminal; Nociceptive Signals to TRPV1 and its Clinical Potential; Gating, Sensitization and Desensitization of TRPV1; TRP Channels as Thermosensors; ASIC Channels; P2X Receptors in Sensory Neurons; Voltage-Gated Sodium Channels and Neuropathic Pain; Voltage-Gated Potassium Channels in Sensory Neurons.
From the internationally bestselling author, keynote speaker and world-renowned business consultant, Nicola Cook, comes this specially expanded and updated 15-year anniversary edition of her powerful and life-changing book A New You. “Everyone should read this book at least once in their life. Jam-packed with nuggets of wisdom, Nicola is a master in her field.” Marc Reklau, international bestselling author of 30Days: Change your habits, change your life. Is there something in your life that’s not working or something about yourself you’d like to change? You’re not alone. Almost all of us feel that way at some time or another. Most of us have things we’d like to be better at, or bad habits we’d like to be rid of. Maybe you’d like to be more confident or more successful. Perhaps you’d like to weigh less, earn more, find a job you love, succeed in business or put the sparkle back into a relationship. Whether there are a few things you need to work on, or whether your whole life needs serious attention, the biggest problem is often knowing where to start, and how to tackle what can feel like a huge mountain to climb. Help is at hand. This special book (newly revised and updated) unlocks the secrets of successful change – and shows you how to make it happen for you, one small step at a time. A New You keeps all the unique and great bits about you but shows you how to lose the unhelpful bits, change whatever needs to be changed, get rid of the mental blocks that are holding you back and help you become all you can be. Order your copy now. It’s time to discover the simple things that over time make the biggest difference to your health, wealth and happiness. It’s time to discover a whole New You. “Nicola is a straight-up, straight-talking, no-BS powerhouse of a woman. If there’s one person who will do what it takes to achieve her goals - it’s Nicola. Author, businesswoman, coach, wife, mother, friend - whatever role she's being, she gives her all. I’ve learnt so much from Nicola over the years, so I read this book full of hope and expectation - I wasn’t disappointed, and you won’t be either.” Emma Cartmell, CEO CHS Group
Bailey Lynn had her life perfectly planned. She thought she was on the path that God had preordained for her. But when her life took an unexpected turn, Bailey was left to question God’s ability to dictate her life. With shattered dreams surrounding her, Bailey found herself looking for answers to where she should go from here. In Unforeseen: Learning to Trust in God’s Plan When Life Takes Unexpected Turns, Bailey shares how she learned to trust God with a future she had never planned. As she battled whether God’s plans for her were truly as good as He had promised in His Word, Bailey began to see that His ways were definitely not like hers—they were better. Bailey shares some of her darkest moments and how, in spite of it all, her life has been more fulfilled when she follows God’s plan. Come along with Bailey to explore how God can direct your future to be more amazing than you could have ever dreamed. Endorsements In her book, Unforeseen, Bailey Lynn is very vulnerable and shares stories to display how God has showed up in her life. I love her writing style and the reflection questions at the end of each chapter. If you need some encouragement and prompting to draw closer to God, this book is for you! Leslie Speas Author of From Hot Mess to MESSage: 90 Days of Messages for the Hot Mess in You and blogger at www.lesliespeas.com Unforeseen is an authentically written book that deepens our walk with God as we learn from Bailey’s keen ability to draw spiritual insight from unusual places. Bailey helps us see Jesus through her life’s journey—whether breaking in a horse, being in a mirror maze, or dealing with a dog with pink eye. Readers will love reading and learning from the stories in this book as they find hope in the midst of their own unforeseen circumstances. Heather Holleman Author of Seated with Christ: Living Freely in a Culture of Comparison Real, honest, and vulnerable, Bailey Lynn offers insight into the valleys of life and what to do when you find yourself in one. Through her soulful writing, Bailey affirms the realities of doubt, confusion, and unanswered questions when life hits hard and situations blindside you. Through Bailey’s stories in Unforeseen: Learning to Trust in God’s Plan When Life Takes Unexpected Turns, you can once again discover purpose and tools to restructure your perspective based on a scriptural foundation. You will be challenged with questions that only you can answer for yourself. This book is practical, inspiring, and deeply spiritual. DeAnna Lynn Sanders Author of Unseen People: Sharing Light and Life with your Neighbors and the Nations
A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes: Extensive coverage and in-depth look into novel treatments and therapeutics Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.
Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patientsâ€"as well as the people who care for themâ€"with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and studentsâ€"in short, anyone who wants to learn more about this important issue.
This book is for educators who believe that schools need to be improved and are hopeful that real change can be achieved. The authors argue that if educators want to create more equitable, socially just, and learner-focused schools, then they need a more robust, transformational theory of school change—an UnCommon Theory. After describing the limits of current school improvement initiatives, the authors explain what is needed to actually engage in deeper school reinvention work. They take a deep dive into the most difficult work that school leaders do: questioning, rethinking, and reinventing the fundamental assumptions upon which our schools are built. The result is a practical book that provides readers with the knowledge and tools needed to do more than just tinker at the edges of school improvement. “This book will serve as a trusty coaching guide. The writing is clear and powerful.” —From the Foreword by Joseph P. McDonald, New York University “Educators contemplating or already on the journey of re-imagining their schools will find comfort and guidance to forge ahead.” —Carl Glickman, The University of Georgia “Can help each of us become the advocates for change that results in a better future for every student in every school.” —Douglas Fisher, San Diego State University “Will support educators to think differently about what it means to not only improve schools, but to move toward sustainable change.” —Kari Thierer, School Reform Initiative
Minerals are, in many ways, the unheralded and often forgotten heroes of keeping our bodies functioning at their best. While the nutrients carbohydrates, proteins and fat may be better well known, minerals are equally vital for helping us get and stay healthy. They play a key role in combatting disease, helping your body heal, managing ongoing chronic health problems such as high blood pressure, minimizing the impact of such common maladies as headaches and PMS, helping children grow up strong, enhancing mental performance at all ages, and fatigue. They truly are your secret weapon for getting and staying your healthiest.In this easy-to-read and easy-to-use guide, pH Lab's team of recognized medical doctors and specialists tell you about the role minerals play with common health issues along with detailed information about individual minerals. You'll also learn more about the relationship between minerals and prescription medicines, why you need more than routine blood tests to see what minerals your body may need, and where you can get these tests.Enjoy your healthy life!