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The key role of histopathology in analysis of a melanocytic tumor is the recognition or exclusion of a malignant melanoma. The analysis of typical features leads to a correct diagnosis in the majority of cases. However, there are cases that are problematic, because of conflicting or insufficient criteria, in which a confident diagnosis is difficult. These difficult lesions account for a large proportion of the diagnostic errors and lawsuits in cutaneous pathology. There is another group of cases in which the diagnosis of malignancy remains uncertain-these cases are especially problematic for both the pathologist and the treating clinician in that the diagnostic uncertainty may affect the recommended treatment and the need to advise the patient of the circumstances. The goal of this unique book is to provide detailed insight into a wealth of expert experience in such cases, with in-depth review of the expert's analysis and diagnostic process supported by high-quality color photomicrographs and discussion of the diagnostic principles involved in evaluating these lesions. Tumorigenic Melanocytic Proliferations is essential reading for surgical pathologists, dermatopathologists and dermatologists. In addition it will of interest to pathology residents and fellows, dermatology residents and dermatopathology fellows. About the Series: The Consultant Pathology series is designed to disseminate the knowledge of expert surgical pathology consultants in the analysis and diagnosis of difficult cases to the full community of pathology practitioners. The volumes are based on actual consultations and presented in a format that illustrates the expert's process of evaluating the case, including indications for consultation, the consultant's findings and comment, and discussion of the entity that amplifies the case description. Each volume in the Consultant Pathology series is authored by international experts with extensive case experience in the areas covered.
The “Abtropfung” theory that nevi develop through the migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of these theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.
Constituting a large percentage of everyday diagnostic practice, melanocytic pathology is a complex and challenging area with many difficult-to-diagnose lesions. This highly illustrated reference, written by three of the world's leading dermatopathologists, provides authoritative guidance in the accurate diagnosis of even the most challenging pigmented skin tumors, helping you avoid pitfalls and recognize mimics. - Covers nearly every variant of melanocytic tumors you're likely to see. - Emphasizes how to arrive at an efficient, accurate diagnosis, and includes dermoscopic findings for optimal diagnostic precision. - Discusses modern analytic techniques (cytogenetics, molecular studies) and how to use them for diagnosis. - Includes numerous case examples to illustrate the differential diagnoses and work-up; how to use ancillary techniques, along with their pros, cons, and limitations; and clinical follow-up. - Presents the knowledge and experience of Klaus Busam, Pedram Gerami, and Richard Scolyer, – three dermatopathologists who are globally renowned for their expertise in melanoma pathology and analysis of melanocytic tumors by modern ancillary diagnostic techniques.
The WHO Classification of Skin Tumours is the 11th volume in the 4th edition of the WHO series on the classification of human tumours. The series (also known as the Blue Books) has long been regarded by pathologists as the gold standard for the diagnosis of tumours, and it is an indispensable guide for the design of evaluations, clinical trials, and studies involving cancer. These authoritative and concise reference books provide an international standard for anyone involved in cancer research or the care of cancer patients. Diagnostic criteria, pathological features, and genetic and other associated molecular alterations are described in a disease-oriented manner. This volume updates the existing ICD-O codes and provides new codes for use in epidemiology and cancer registration. It also provides information on clinical features, pathology, genetics, prognosis, and protective factors for each of the tumour types covered. The editors expect that this volume will be of particular interest to pathologists, oncologists, and dermatologists who manage or research skin tumours. Sections are included on all recognized neoplasms (and their variants) of the skin and its adnexae. Since the previous edition, there have been particularly substantial changes to the classification of melanoma, based on the latest information from genetic and molecular studies.
Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors of melanoma to advanced stages of metastatic disease.
Imaging in Dermatology covers a large number of topics in dermatological imaging, the use of lasers in dermatology studies, and the implications of using these technologies in research. Written by the experts working in these exciting fields, the book explicitly addresses not only current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing clinicians and researchers with a clear understanding of the advantages and challenges of laser and imaging technologies in skin medicine today, along with the cellular and molecular effects of these technologies. - Outlines the fundamentals of imaging and lasers for dermatology in clinical and research settings - Provides knowledge of current and future applications of dermatological imaging and lasers - Coherently structured book written by the experts working in the fields covered
Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. In this volume, all aspects of the diagnosis, histopathology, genetics and treatment of retinoblastoma are discussed in detail.
The interpretation of melanocytic tumors represents probably the most difficult task in the field of dermatopathology. The second edition of this text and atlas depicts a broad range of the most important and most challenging melanocytic lesions. Each individual case is illustrated with at least three high-quality color photographs and is commented on at length, highlighting the diagnostic clues. The goal of the authors is to assist the ordinary pathologist in making a precise workable diagnosis in their daily practice. They achieve this by providing simple criteria that will serve as a sound basis for an unequivocal diagnosis of either a benign or a malignant melanocytic neoplasm. The reader will find Histological Diagnosis of Nevi and Melanoma to be an invaluable guide to correct diagnosis even in difficult or rare cases.
Cutaneous Melanoma: A Pocket Guide for Diagnosis and Management serves as an easy-to-consult, short, and schematic reference providing guidelines for diagnosing and managing melanoma in the context of various clinical scenarios. In the daily routine of a busy clinician, there is a need for schematic reference tools that allow quick consultation for immediate decisions. Melanoma is a deadly disease that should be promptly managed following precise and evidence-based guidelines. The guide contains many schematics and figures, vastly outnumbering the pages dedicated to text. This guide follows the sequence of a real clinical setting, going from the first screening visit to the final stages of terminal patients. - Provides a quick-access resource for diagnosis and treatment of melanoma patients at all stages - Includes succinct guidelines, schematics, and figures for busy clinicians - Concludes with a section addressing special clinical situations, including melanoma in pregnancy, pediatric melanoma, familial melanoma and MPM, atypical Spitz tumor, occult primary melanoma, and the histopathologic gray zone