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'Essential Tremor' is a guide for sufferers to minimising the impact it has on their lives. It provides first-hand advice on the causes of, treatment options for, and methods of coping with this condition.
Anthony, Shamus, and Lefty Award Finalist Powerful forces on each side of the law have Rick Cahill in the crosshairs Nightmares of the man he killed two years ago still chase Rick Cahill through his sleep. The memory of his murdered wife haunts him during waking hours. His private investigative work, secretly photographing adulterers, paid for his new house but stains his soul. When an old nemesis asks for his help to free a man from prison, a man he thinks is wrongly convicted of murder, Rick grabs at the chance to turn his life around. His investigation takes him from the wealthy enclave of La Jolla to the dark underbelly of San Diego. His quest fractures his friendship with his mentor, endangers his steady job, and draws the contempt of the Police Chief who has tried to put Rick behind bars forever. With the police on one side of the law and a vicious biker gang on the other, all trying to stop him from freeing the man in prison, Rick risks his life to uncover the truth that only the real killer knows—what happened one bloody night eight years earlier. Perfect for fans of David Baldacci While all of the novels in the Rick Cahill PI Crime Series stand on their own and can be read in any order, the publication sequence is: Yesterday's Echo Night Tremors Dark Fissures Blood Truth Wrong Light Lost Tomorrows Blind Vigil Last Redemption (coming November 2021)
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.
Tremor represents one of the most common movement disorders worldwide. It affects both sexes and may occur at any age. In most cases, tremor is disabling and causes social difficulties, resulting in poorer quality of life. Tremor is now recognized as a public health issue given the aging of the population. Tremor is a complex phenomenon that has attracted the attention of scientists from various disciplines. Tremor results from dynamic interactions between multiple synaptically coupled neuronal systems and the biomechanical, physical, and electrical properties of the external effectors. There have been major advances in our understanding of tremor pathogenesis these last three decades, thanks to new imaging techniques and genetic discoveries. Moreover, significant progress in computer technologies, developments of reliable and unobtrusive wearable sensors, improvements in miniaturization, and advances in signal processing have opened new perspectives for the accurate characterization and daily monitoring of tremor. New therapies are emerging. In this book, we provide an overview of tremor from pathogenesis to therapeutic aspects. We review the definitions, the classification of the varieties of tremor, and the contribution of central versus peripheral mechanisms. Neuroanatomical, neurophysiological, neurochemical, and pharmacological topics related to tremor are pointed out. Our goals are to explain the fundamental basis of tremor generation, to show the recent technological developments, especially in instrumentation, which are reshaping research and clinical practice, and to provide up-to-date information related to emerging therapies. The integrative transdisciplinary approach has been used, combining engineering and physiological principles to diagnose, monitor, and treat tremor. Guidelines for evaluation of tremor are explained. This book has been written for biomedical engineering students, engineers, researchers, medical students, biologists, neurologists, and biomedical professionals of any discipline looking for an updated and multidisciplinary overview of tremor. It can be used for biomedical courses. Table of Contents: Introduction / Anatomical Overview of the Central and Peripheral Nervous System / Physiology of the Nervous System / Characterization of Tremor / Prinipal Disorders Associated with Tremor / Quantification of Tremor / Mechanisms of Tremor / Treatments
The Bard meets "House" in this illumination of the medical mysteries surrounding 10 of the English language's most heralded writers, including John Milton, Jonathan Swift, and Jack London.
Since the Global Financial Crisis, the structure of financial markets has undergone a dramatic shift. Modern markets have been “zombified” by a combination of Central Bank policy, disintermediation of commercial banks through regulation, and the growth of passive products such as ETFs. Increasingly, risk builds up beneath the surface, through a combination of excessive leverage and crowded exposure to specific asset classes and strategies. In many cases, historical volatility understates prospective risk. This book provides a practical and wide ranging framework for dealing with the credit, positioning and liquidity risk that investors face in the modern age. The authors introduce concrete techniques for adjusting traditional risk measures such as volatility during this era of unprecedented balance sheet expansion. When certain agents in the financial network behave differently or in larger scale than they have in the past, traditional portfolio theory breaks down. It can no longer account for toxic feedback effects within the network. Our feedback-based risk adjustments allow investors to size their positions sensibly in dangerous set ups, where volatility is not providing an accurate barometer of true risk. The authors have drawn from the fields of statistical physics and game theory to simplify and quantify the impact of very large agents on the distribution of forward returns, and to offer techniques for dealing with situations where markets are structurally risky yet realized volatility is low. The concepts discussed here should be of practical interest to portfolio managers, asset allocators, and risk professionals, as well as of academic interest to scholars and theorists.