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Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: • Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. • Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. • Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included. • Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.
Translational Gastroenterology covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts including case-control study, prospective cohort study, randomized trial, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in gastroenterology, and know what is needed in collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in gastroenterology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every medical researcher or gastroenterologist who has ever had a good clinical idea but not the knowledge of how to test it.
Encyclopedia of Gastroenterology, Second Edition provides a comprehensive and concise reference on all aspects of gastroenterology and hepatology, including the organs in the gastrointestinal system, their functions in health and disease, and strategies or procedures to resolve or prevent problems and disease. This concise, up-to-date information includes comprehensive sections on the impact of nutrition, gastrointestinal microbiota, lifestyle, commonly used drugs, and surgical procedures on health and disease. Since the first edition, attention to the roles of nutrition and gastrointestinal microorganisms (microbiota, formerly Microbiota) in health and disease has skyrocketed. In addition, an entirely new section on obesity and diabetes is included. Presents comprehensive coverage of every topic within gastroenterology Offers researchers a one-stop, fully-referenced resource to explore questions Includes teaching tools, multimedia and interactive elements Provides readers with multi-layered content and a media-rich learning resource for both instructors and students Covers hot new topics in GI health and disease, including new sections on stem cells, intestinal bacteria, obesity and intestinal microbiota
Gastroenterology is a critically important specialty in medicine, encompassing the GI tract and two vital organs - the pancreas and the liver. Gastroenterology: Clinical Cases Uncovered includes reference to the new JCHMT curriculum for acute and internal medicine concerning gastroenterology and hepatology and presents real-life patient cases and outcomes as seen on the wards and in exams leading students through a practical approach to recognize, understand, investigate and manage gastroenterological and hepatological disorders and conditions. Following a question-answer approach, with self-assessment MCQs, EMQs and SAQs, and a 'refresher' section on basic science, Gastroenterology: Clinical Cases Uncovered features investigations and the treatment options available for patients with upper and lower GI disorders, liver disease, biliary and pancreatic disease, and problems of nutrition. Gastroenterology: Clinical Cases Uncovered is ideal for medical students, junior doctors on the Foundation Programme, GP trainees, specialist nurses and nurse practitioners and gastroenterology trainees on the specialty training programme.
Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
A holistic approach for healing trauma stored in the gut • Explains how and why emotions and trauma are stored in the gut, causing digestive issues and visceral tensions • Presents recent research that enriches our understanding of the gut as a center of emotional and spiritual growth • Shares a hands-on process of listening to the gut layer by layer to help heal gut issues, renew the microbiome, and release intergenerational trauma A healthy gut is fundamental to a healthy life. Embedded within our digestive ­system is the enteric nervous system, our “second brain,” which serves to protect us from the external world of adversity, including not only viruses and bacteria, but also traumatic events. As Nikki Kenward, CST-D, MCSS, explains, past challenges and traumas, whether emotional or physical, are held in the enteric nervous system in many ways, including fascial tension, cellular changes, and unhelpful “default settings.” Exploring in depth what she calls “the Post-Traumatic Gut,” Kenward describes the anatomy and physiology of the enteric nervous system, including the polyvagal system, and the many ways that our emotional history and current emotional state can impact our digestive system. Sharing recent research, she describes the science behind the emotional gut and how to apply it to chronic digestive issues like IBS and Crohn’s disease as well as mental health issues such as anorexia, bulimia, anxiety, and depression. She explains how and why the digestive gut absorbs emotions and what you can do to heal its functions by addressing psychosomatic stressors, rather than just nutrition. Presenting case studies from her 25 years in clinical practice as well as her own healing journey, she reveals the synchronicity between digestive/metabolic functions and psychological/perceptual insight and how allowing the cells to “speak” through bodywork such as CranioSacral Therapy and SomatoEmotional Release Therapy can help renew the microbiome of the second brain, release intergenerational trauma and illness, and restore one’s psychospiritual life. Sharing visualization exercises and a hands-on process of listening to the gut layer by layer, the author helps readers unwind stagnant cellular patterns, discover the dynamic intelligence in every cell, and transform Post-Traumatic Gut into Post-Traumatic growth.
Dr Roy Soetikno and Dr Tonya Kaltenbach are the editors for this issue of Gastrointestinal Endoscopy Clinics of North America, which is devoted to the improved detection and management of early neoplasia in inflammatory bowel disease. An important aspect of Dr Soetikno’s outstanding career has been the bridging of endoscopic methods between Japan and the United States. Endoscopists in Japan have a better record of detecting subtle flat GI lesions. From the earliest days of endoscopy, it is fair to say that Japanese endoscopists have emphasized visual identification, analysis, and photo documentation of small GI lesions. The colon has been no exception. Dr Soetikno has incorporated these techniques, which have become increasingly feasible with steady improvement in modern digital endoscopes. Identifying small flat premalignant lesions and early cancers in patients with colitis can be lifesaving. Dr Soetikno and Dr Kaltenbach have edited an extraordinary issue of the Gastrointestinal Endoscopy Clinics of North America devoted to teaching and promulgating these methods, including an extensive photo atlas, which should be an invaluable resource for all academic specialists and practicing gastroenterologists.
Medical Therapy of Ulcerative Colitis will serve as an invaluable resource for individual physicians use who treat patients with ulcerative colitis. The text presents a comprehensive overview of medical therapy for management of specific clinical scenarios and also a focus on the individual medications used to treat patients with ulcerative colitis. The book will be evidence based and focus on simplifying the current treatment to make it easy to understand. The chapters are written by experts in their fields and provide the most up to date information. This book will target gastroenterologists who focus on IBD, general gastroenterologists, fellows, and surgeons such as colorectal surgeons or GI surgeons who may treat patients with ulcerative colitis.
There have been many advances in the management of this condition since the first edition of Gastrointestinal Bleeding. This new edition, thoroughly revised and restructured, includes the latest updates on all areas of the field of GI Bleeding, systematically covering all the areas of the GI tract, from upper GI to lower GI, through to small bowel bleeding. It fully covers the different types of bleeding that can occur, from peptic ulcer through to variceal bleeding and looks at new developments and pioneering techniques in the field, including endoscopy and balloon-enteroscopy. A methodology section describes the latest design of clinical trials in GI bleeding and this edition now highlights the new guidelines on UGIB (Upper gastrointestinal bleeding). This new edition of Gastrointestinal Bleeding is an invaluable purchase for all gastroenterologists, both in training and fully qualified.
The Physician Scientist’s Career Guide provides a complete guide to having a successful career as a Physician Scientist. Filled with first-hand experiences and practical advice, it guides readers through each step of this career path, from choosing a degree and training program, to navigating the tenure track, and through the intricacies of applying for and obtaining funding. The volume is unique in that it provides an overview of this entire career path, allowing readers to envision and prepare for their futures. The Physician Scientist’s Career Guide fulfills a unique and crucial need and will be an invaluable guide for medical students, fellows and newly appointed faculty members interested in a career in research.