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Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.
The term “Translational Research” reflects today’s integration of basic research (“bench”) findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient (“bedside”) to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment. Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium and the use of microRNAs. As such, this book will be relevant to young physicians, nurses and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.
Encyclopedia of Cardiovascular Research and Medicine, Four Volume Set offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.
Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source. - Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data - Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease - Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease
The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.
This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.
This issue of Cardiology Clinics, edited by Sharmila Dorbala and Piotr Slomka, examines Nuclear Cardiology. Topics include Advances in SPECT Hardware and Software; Advances in PET Hardware and Software; Technical Advances and Clinical Applications of Cardiac PET/MR; Translational Coronary Atherosclerosis Imaging (NaF PET, FDG); Quantitative Nuclear Cardiology Using New Generation Equipment; Myocardial Perfusion Flow Tracers; Translational Molecular Nuclear Cardiology; Radionuclide Imaging in Congestive Heart Failure (Sarcoid, Amyloid, Viability); Clinical Applications of Imaging Myocardial Innervation; Gated Radionuclide Imaging Including Dyssynchrony Assessment; Clinical PET Myocardial Perfusion Imaging Including Flow Quantitation; and Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease.
Coronary heart disease (CHD) is the leading cause of death worldwide. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems.
An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.
An authoritative, comprehensive, and accessible cardiology textbook that caters to the needs of trainees and practicing cardiologists. Cardiovascular disease is now the largest contributor to global mortality. Low and middle income countries. (Lmics) presently bear the brunt of this global epidemic, accounting for over three quarters of cardiovascular deaths and 90% of these deaths under 70 years of age. The experience and expertise of health professionals in these countries will therefore be the principal determinant of global success in countering and curbing the global cardiovascular epidemic in the coming decades. This book covers the fundamentals of cardiology in depth, to provide conceptual clarity, and delves into specific cardiovascular disorders with detailed descriptions that range from aetiology and pathophysiology to evidence informed approaches to diagnosis and management. It does all of this by blending contextual relevance with uncompromising academic rigor.