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Interactivity is the catchword for a wide range of innovative solutions that concept designers and engineers are developing in every area of technology and culture. For the authors interaction is more than a technological or aesthetic concept, it is a new means to ally humans and technology in a dynamic and reciprocal form of “living in technology”. This publication gathers together scientists and contributors from diverse fields of activity, providing a fascinating, up-to-date survey of the technological and conceptual equipment of experts engaged in aesthetic disciplines and product design. The editor, Professor Gerhard M. Buurman, is Head of Interactiondesign at the University of Art, Media and Design (HGKZ) in Zurich.
This book is about making machine learning models and their decisions interpretable. After exploring the concepts of interpretability, you will learn about simple, interpretable models such as decision trees, decision rules and linear regression. Later chapters focus on general model-agnostic methods for interpreting black box models like feature importance and accumulated local effects and explaining individual predictions with Shapley values and LIME. All interpretation methods are explained in depth and discussed critically. How do they work under the hood? What are their strengths and weaknesses? How can their outputs be interpreted? This book will enable you to select and correctly apply the interpretation method that is most suitable for your machine learning project.
This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock and key theory. The author achieved the first total synthesis of TB1 and its spin-labeled derivative to carry out NMR experiments because the supply of TB1 from natural sources was limited. Unique 2,2’,6,6’-tetrasubstituted diphenyl ether moiety of TB1 was synthesized from a depsidone skeleton by chemoselective reduction of lactone. In the process of elongating side wings, efficient formylation utilizing dichloromethyl methyl ether–silver trifluoromethanesulfonate was developed for the sterically hindered aromatic compound. NMR titration experiments and paramagnetic relaxation enhancement observation of PAC3 homodimer were performed with synthesized TB1 and its molecular probe, respectively. The results of the above NMR studies and additional in silico docking studies suggested that TB1 promotes the dissociation to monomeric PAC3 after interaction with PAC3 homodimer. The rare mechanism shown in this book indicates a potential novel drug target in the interfaces of PPIs with no cavity or groove.
The sixth edition includes new developments, as well as new experiments in quantum entanglement, Schrödingers cat, the quantum computer, quantum information, the atom laser, and much more. Many experiments and problems are included.
Nuclear structure Physics connects to some of our fundamental questions about the creation of universe and its basic constituents. At the same time, precise knowledge on the subject has lead to develop many important tools of human kind such as proton therapy, radioactive dating etc. This book contains chapters on some of the crucial and trending research topics in nuclear structure, including the nuclei lying on the extremes of spin, isospin and mass. A better theoretical understanding of these topics is important beyond the confines of the nuclear structure community. Additionally, the book will showcase the applicability and success of the different nuclear effective interaction parameters near the drip line, where hints for level reordering have already been seen, and where one can test the isospin-dependence of the interaction. The book offers comprehensive coverage of the most essential topics, including: • Nuclear Structure of Nuclei at or Near Drip-Lines • Synthesis challenges and properties of Superheavy nuclei • Nuclear Structure and Nuclear models - Ab-initio calculations, cluster models, Shell-model/DSM, RMF, Skyrme • Shell Closure, Magicity and other novel features of nuclei at extremes • Structure of Toroidal, Bubble Nuclei, halo and other exotic nuclei These topics are not only very interesting from theoretical nuclear physics perspective but are also quite complimentary for ongoing nuclear physics experimental program worldwide. It is hoped that the book chapters written by experienced and well known researchers/experts will be helpful for the master students, graduate students and researchers and serve as a standard & uptodate research reference book on the topics covered.
There are a number of people I wish to acknowledge for helping me write this book. First, the idea of politics as a nonequilibrium process owes its origins largely to a series of ongoing conservations I have had with Father Richard Telnack, o. c. s. o. Our discussions of Augustine's city of God and Hegel's Phenomenology in the hours before the night office led me to think about the world more as an ongoing flux than as a static rational order. The use of structurally unstable dynamical systems to. model democratic politics was greatly enhanced by my interactions with Professor Alex Kleiner, department of mathematics, Drake University. Professor Manfred Holler of the University of Aarhus provided a detailed critique of an earlier version. His insights and remarks were invaluable in improving the work's content and structure. I also wish to thank Dr. Werner A. Muller, director of Physica Verlag for his confidence in my work and his efforts on my behalf. Miss Jane Blevins was a patient and thorough typist. I thank her for her attention to the production of the manuscript. Finally, writing a book is in one way a moral act. It requires committment to pursue a line of thought to its conclusion when the final results are not clear. without the encouragement and support of my wife over a long period of time, I would have certainly faltered. Whatever good emerges from the work is due largely to her example and patient endurance.
The most authoritative and comprehensive book available on dreams and dreaming. Enter the fascinating world of dreams, their mysteries, their meanings: to dream of a bird flying freely represents hopes and aspirations; to dream of winter means a time in life that is not fruitful; to be visited by someone in a dream can mean that there is information, warmth, or love available; to be searching in a dream is an attempt to find an answer to a problem. These are just a few of the 10,000 dream images and interpretations contained in this volume, a book that can bring insight, clarification, and guidance.
This book presents a systematic and comprehensive review of the information on chromatographic processes that involve the formation of coordination compounds, aiming not only to demonstrate the achievements that have been made in the theory of praxis of chromatography, but also to point out, as far as possible, the future of potential of ligand exchange chromatography.
This textbook brings together nuclear and particle physics, presenting a balanced overview of both fields as well as the interplay between the two. The theoretical as well as the experimental foundations are covered, providing students with a deep understanding of the subject. In-chapter exercises ranging from basic experimental to sophisticated theoretical questions provide an important tool for students to solidify their knowledge. Suitable for upper undergraduate courses in nuclear and particle physics as well as more advanced courses, the book includes road maps guiding instructors on tailoring the content to their course. Online resources including color figures, tables, and a solutions manual complete the teaching package. This textbook will be essential for students preparing for further study or a career in the field who require a solid grasp of both nuclear and particle physics.