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This eighty-ninth volume of the IARC Monographs is the third and last of a series on tobacco-related agents. Volume 83 reported on the carcinogenicity of tobacco smoke and involuntary smoking (second-hand smoke or environmental tobacco smoke) (IARC 2004a). Volume 85 summarized the evidence on the carcinogenic risk of chewing betel quid with and without tobacco (IARC 2004b). That volume explored the variety of products chewed in South Asia and other parts of the word that contain areca nut in combination with other ingredients, often including tobacco. In this eighty-ninth volume, the carcinogenic risks associated with the use of smokeless tobacco, including chewing tobacco and snuff, are considered in a first monograph. The second monograph reviews some tobacco-specific nitrosamines. These agents were evaluated earlier in Volume 37 of the Monographs (IARC 1985) and information gathered since that time has been summarized and evaluated.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Over 1,100 delegates from a hundred countries attended the 9th World Conference onTobaccoandHealth. Afterfivedaysofdebate, severalimportantresolutionswereadopted unanimously and will be landmarks in the fight against tobacco. This great success is due to three facts which emerged from the discussions: 1. Itappears clearlynowthattherisksassociated withtobaccoaremuchgreaterthan previously assumed. Out of two regular smokers, one will die from a tobacco­ related disease. 2. Reducing tobacco consumption can be achieved but the data collected in several countriesshowthatitrequiresaglobalstrategy.Thisstrategywasmuchdebatedduring theconference. Theresolutionsadoptedemphasizetheagreementofthedelegateson themainpoints. Actionto fight thegrowingepidemicoftobacco-attributabledisease and death involves convincing the general public, the medical community and decision-makers ofthe need to act for tobacco control. The most efficient tools for helping individuals never to start or successfully to stop using tobacco should be developed; effective tobacco control endeavors are required to counteractthe actions ofthe powerful and influential tobacco manufacturers. With the help and under the aegis ofWHO, DICC, IUATLD, ISFC, IOCD, and IUHPE, an international alliance for health and against tobacco shouldunite all those who are engaged in this fight.
For years now we've all heard the dangers of smoking cigarettes. To avoid those health risks, many people have turned to "chew," "plug," "chaw"-smokeless tobacco. No smoke, no danger. Right?
This comprehensive multidisciplinary book examines all aspects of cancers of the mouth and oropharynx with the aim of equipping advanced students and practitioners in the early stages of specialist training with an up-to-date guide and reference. A multinational team of authors – all experts in the field of oral oncology – provide illuminating contributions on the full range of relevant topics: epidemiology, risk factors, clinical features, staging and prognostic factors, pathology, diagnostic techniques, disease prevention, surgery, radiotherapy, and chemotherapy. Molecular biology, molecular targeted therapies for advanced cases, and future diagnostic and prognostic applications of new technologies also receive careful attention. In providing a wealth of essential information and guidance in a practical format, the book will be a superb asset for senior graduate students in dentistry and specialist trainees in head and neck oncology. It will also be of high value for the many physicians, surgeons, pathologists, dentists, and specialists involved in the prevention, diagnosis, and management of squamous cell carcinomas of the oral cavity and oropharynx.
If you smoke and are unable or unwilling to quit, this approach can save your life. The book, For Smokers Only: How Smokeless Tobacco Can Save Your Life, provides concrete facts and valuable advice on a revolutionary quit-smoking strategy that is based on scientific research and common sense. Itis written by Dr. Brad Rodu, a leading authority on tobacco harm reduction, and a professor and senior scientist at the University of Alabama/Birmingham Comprehensive Cancer Center. Dr. Roduis stop-smoking strategy is based on three simple facts: 1. Smokers are addicted to nicotine, but nicotine does not cause cancer, heart attacks or emphysema. Those illnesses are caused by the other 3000 products of tobacco combustion. 2. Smokeless tobacco satisfies nicotine craving, but smokeless is 98% safer than smoking. 3. Todayis smokeless, spitless tobacco products can be used invisibly anytime, anywhere, much like a breath mint. "Please surf this site for lots of useful, factual information that can save your life, and the lives of your friends and loved ones." -- Dr. Brad Rodu"
Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes. Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.
Without early detection, oral cancer is deadly. Protect your patients by applying the latest clinical interventions. Rates of new oral cancer cases continue to increase and mortality rates remain alarmingly high. Oral cancer may be preceded by clinically identifiable precancerous changes in the oral mucosa, which offer a therapeutic window of opportunity to intervene and halt disease progression to carcinoma development. Written and edited by prominent researchers in the field, Oral Precancer: Reviews current scientific research on precancer conditions of the oral cavity providing evidence-based analysis of the nature and behavior of potentially malignant and deforming oral diseases Explains the principles of prevention, diagnosis and management of potentially malignant disorders of the oral cavity Details a practical and reliable interventional treatment strategy to facilitate early diagnosis and effective treatment of both precancer and early invasive carcinoma Contains a chapter devoted to illustrative case histories, high-quality, color, clinical photos, reference sections in each chapter listing relevant review articles, and more From start to finish, Oral Precancer offers undergraduate students, clinicians, and professors an invaluable resource to minimise the morbidity and mortality of this most significant and life threatening of oral conditions.