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"Vitamin D: From Biochemistry to Therapeutic Frontiers" offers an expansive exploration of this crucial nutrient's multifaceted role. Delve into the intricate biochemistry, comprehensive anatomy, and the significance of Vitamin D in holistic health. Uncover its diverse forms, the science behind D2 versus D3, and understand why this vitamin is vital for the body's optimal functioning. From bone health to immune system modulation, this treatise meticulously examines Vitamin D's involvement in various bodily functions. Learn how it influences bone formation, calcium regulation, and discover its surprising extra-skeletal roles in immune system fortification, cell growth, and neurological functions.
In all organisms, the DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Inhibitors of replication proteins are commonly used in anti-cancer and anti-viral therapies. This eBook on “The DNA Replication Machinery as Therapeutic Targets” examines the normal functions of replication proteins as well as strategies to target each step during the replication process including DNA unwinding, DNA synthesis, and DNA damage bypass and repair. Articles discuss current strategies to develop drugs targeting DNA replication proteins as well as future outlooks and needs.
If family therapy is like a camera through which clients are able to view their lives, then the treatment method used by clinicians could be considered the lens, offering different ways of seeing. In Metaphors of Family Systems Theory, Paul C. Rosenblatt explores the metaphors of family systems theory that form the conceptual foundation - the lens - of a great deal of therapy, research, theory, education, and policy making in the family field. He demonstrates the value of testing out theoretical or alternative metaphors - other lenses - to provide new perspectives and a fresh means of gaining clarity. The literature that informs family therapy is rich with striking accounts of how therapeutic metaphors have helped to move families into healthier, energizing, freeing, and more satisfying relationships, yet little attention has been devoted to the development of alternative theoretical metaphors. This innovative new work investigates the uses and limitations of the standard metaphors of family systems theory. Perhaps more important, it also provides the means to generate alternative theoretical metaphors to stimulate new thinking about family systems. Rosenblatt asserts that the capacity to recognize metaphors will enable clinicians and clients to identify biases, hidden implications, and reification, as well as what may have been overlooked. He shows the way this ability also helps us to organize and remember information, and to better appreciate the multilayeredness of "reality". Initial chapters define metaphor and discuss family systems theory, as well as the uses and limitations of standard therapeutic metaphors. The chapters examine the notion of the family as an entity, themetaphor of "system", and the major systemic metaphors. Rosenblatt extends his analysis to the idea of family boundary and to the closely related metaphors of family subsystem, family boundary permeability, and family boundary ambiguity. He also analyzes the metaphors of family structure, systems control, family rules, and negative and positive feedback. Later chapters apply these ideas to the metaphors of communication, therapeutic goals, the therapist in the system, and family response to intervention. Rosenblatt Illustrates new insights with a variety of experience-based metaphors and presents strategies for the evaluation and development of new theoretical metaphors for family systems. Unique and innovative, this book offers a fresh perspective for anyone working with metaphors of family systems theory. Of special interest to family therapists, family researchers, social workers, and other mental health professionals working in the family field, it is especially useful as a text for courses in family systems theory, theories of family therapy, and theory construction.
Among neurodegenerative diseases, those that lead to a state of dementia are the aim of several investigations. Dementia is a chronic disease the prevalence of which is increasing worldwide. The number of dementia patients in the world is approximately 50 million, and it is estimated that the number of patients will reach 131.5 million by 2050. This increase will be accompanied by a significant increase in medical expenditures and other expenses, especially for elderly patients. Therefore, the maintenance cost of dementia in the future is expected to be quite high. For this reason, several investigations aim, firstly, to describe the key mechanisms involved in the origin of dementia and, secondly, to establish preventive and therapeutic strategies in order to understand and mitigate this debilitating pathology. This volume of Frontiers in Clinical Drug Research - Dementia explores the current comorbidities that cause cognitive impairment and the current management alternatives for clinical cases of dementia. The reviews contributed in these volume will provide readers with a current perspective on the subject. The topics covered in this volume include: - Comorbidities inducing mild cognitive impairment - an evaluation of the risk caused by some pathological conditions - Tau-targeted therapy in Alzheimer's disease - history and current state - Emerging nanotherapeutic strategies in Alzheimer's disease - Implication of dehydroepiandrosterone on dementia related to oxidative stress - Polyphenol compounds as potential therapeutic agents in Alzheimer’s disease The volume is a timely update on dementia treatment for clinical physicians, neurologists, gerontologists, pharmaceutical and medicinal chemistry researchers, and physiologists.
Topic Editor Susan Richards is an employee of Sanofi and owns stock in the corporation. Topic Editor Bernard Maillere declares economic support from pharmaceutical companies (Novartis, Sanofi, and UCB) in the frame of collaborations aiming to evaluate the recognition by human T cells of therapeutic proteins and antibodies.
Environmental Arts Therapy: The Wild Frontiers of the Heart describes what happens when we take the creative arts therapies and the people whom we work with out of doors in order to provide safe, structured and accompanied creative therapeutic healing experiences. The theoretical themes are developed along with illustrated examples of clinical practice across a variety of settings and locations. The work is introduced and co-edited by a pioneer in the field, Ian Siddons Heginworth, who describes the emergence of environmental arts therapy and its growth across the British Isles supported through the training course based in London. The following 12 chapters are written by contributing authors and creative arts therapy practitioners working with children, adults and elders in schools, adult mental health and private practice in Britain and Europe. A central focus of the book is the clinical populations and settings in which clinicians work, and it also describes the health benefits as well as the challenges faced when working out of doors. This is a book about the emergence of a new creative therapy modality in the British Isles. It shows the value of working with the natural cycles and seasons, using an integrative arts approach including dramatic enactment, role-play, poetry, art-making with natural materials, storytelling, and the use of bodywork through movement, sound, rhythm and the voice, all held and reflected by our encounters with and in nature. It is about our relationship with nature, creativity and therapeutic healing and is written for trainers, trainees and practitioners in the creative arts, psychotherapy and ecotherapy.
Developmental neuroscience research is on the cusp of unprecedented advances in the understanding of how variations in brain structure and function within neural circuits confer risk for symptoms of childhood psychiatric disorders. Novel dimensional approaches to illness classification, the availability of non-invasive, diverse and increasingly sophisticated methods to measure brain structure and function in humans in vivo, and advances in genetics, animal model and multimodal research now place brain-based biomarkers within reach in the field of psychiatry. These advances hold great promise for moving neuroscience research into the clinical realm. One exciting new area of translational research in child and adolescent psychiatry, is in the use of a variety of neuroscience research tools to track brain response to clinical intervention. Examples of this include: using longitudinal neuroimaging techniques to track changes in white matter microstructure following a training intervention for children with poor reading skills, or using functional imaging to compare brain activity before and after children with bipolar disorder begin taking psychotropic medication treatment. Brain stimulation is another cutting-edge research area where brain response to therapeutic intervention can be closely tracked with electroencephalography or other brain imaging modalities. Research using neuroscience tools to track brain response to clinical interventions is beginning to yield novel insights into the etiopathogenesis of psychiatric illness, and is providing preliminary feedback around how therapeutic interventions work in the brain to bring about symptom improvement. Using these novel approaches, neuroscience research may soon move into the clinical realm to target early pathophysiology, and tailor treatments to both individuals and specific neurodevelopmental trajectories, in an effort to alter the course of development and mitigate risk for a lifetime of morbidity and ineffective treatments. Excitement and progress in these areas must be tempered with safety and ethical considerations for these vulnerable populations. This research topic focuses on efforts to use neuroscience research tools to identify brain-based biomarkers of therapeutic response in child and adolescent psychiatry.