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A Book of the Year for The Economist and the Observer Our world seems to be collapsing. The daily news cycle reports the deterioration: divisive politics across the Western world, racism, poverty, war, inequality, hunger. While politicians, journalists and activists from all sides talk about the damage done, Johan Norberg offers an illuminating and heartening analysis of just how far we have come in tackling the greatest problems facing humanity. In the face of fear-mongering, darkness and division, the facts are unequivocal: the golden age is now.
A journey in search of the primary forces that either fuel or destroy progress in companies today. Scientists changed our world by proving that the complex world of physics is ruled by only a few forces which obey simple Laws. This allowed a quantum leap in our progress. In this business novel an Eastern woman teams up with a Western turnaround guy to master the forces that are limiting their progress in business. They set their aim as high as the imagination will allow: *For their traditional products company to achieve a Viable Vision - to turn its sales into its net profits in 4 years, and *To encourage their people to escape from the rat race by becoming millionaires - free to pursue their real purpose in life. They use ancient Laws and wisdoms to defeat the forces that stand in their way. Is it possible that a traditional business is also ruled by a few distinct forces - which could be mastered to allow for a quantum leap in the performance of the business and its people?
“Historian Schiavone mixes philosophy, politics, and anthropology in this stimulating inquiry into the ‘paradigm of progress.’” —Publishers Weekly Today, many believe that progress is a word to be avoided, a relic from a past, the dangerous product of an era of intellectual naivety that would be best forgotten. Yet, the idea of progress is rooted in a human impulse that is both profound and essential, a way of interpreting history without which our ability to plan the future—and our very identity—would be at stake. Written just before the onset of the Coronavirus pandemic—which is now putting its argument to the hardest of tests—this lucid essay explores how science and technology have been, and can still be, a powerful engine for human advancement.
The idea of progress from the Enlightenment to postmodernism is still very much with us. In intellectual discourse, journals, popular magazines, and radio and talk shows, the debate between those who are "progressivists" and those who are "declinists" is as spirited as it was in the late seventeenth century. In History of the Idea of Progress, Robert Nisbet traces the idea of progress from its origins in Greek, Roman, and medieval civilizations to modern times. It is a masterful frame of reference for understanding the present world. Nisbet asserts there are two fundamental building blocks necessary to Western doctrines of human advancement: the idea of growth, and the idea of necessity. He sees Christianity as a key element in both secular and spiritual evolution, for it conveys all the ingredients of the modern idea of progress: the advancement of the human race in time, a single time frame for all the peoples and epochs of the past and present, the conception of time as linear, and the envisagement of the future as having a Utopian end. In his new introduction, Nisbet shows why the idea of progress remains of critical importance to studies of social evolution and natural history. He provides a contemporary basis for many disciplines, including sociology, economics, philosophy, religion, politics, and science. History of the Idea of Progress continues to be a major resource for scholars in all these areas.
This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
The first contribution describes apolar and polar molecular fossils and, in particular biomarkers, along the lines usually followed in organic chemistry textbooks, and points to their bioprecursors when available. Thus, the apolar compounds are divided in linear and branched alkanes followed by alicyclic compounds and aromatic and heterocyclic molecules, and, in particular, the geoporphyrins. The polar molecular fossils contain as functional groups or constituent units ethers, alcohols, phenols, carbonyl groups, flavonoids, quinones, and acids, or are polymers like kerogen, amber, melanin, proteins, or nucleic acids. The final sections discuss the methodology used and the fundamental processes encountered by the biomolecules described, including diagenesis, catagenesis, and metagenesis. The second contribution covers the distribution of phthalides in nature and the findings in the structural diversity, chemical reactivity, biotransformations, syntheses, and bioactivity of natural and semisynthetic phthalides.
The first contribution of this book gives an overview on naturally occuring cycling tetrapyrroles. The article describes the four classic tetrapyrrolic structures with their porphyrin, chlorin, bacteriochlorin and corrin skeletons and also novel, interesting structures with unusual biological activities. This review mainly focuses on the occurrence, structure and biological function as well as biosynthesis and aspects of synthesis. The second article deals with the anticancer compound taxol and its semisynthetic analog docetaxel (Taxotere). Taxol was originally isolated in the late 1960 ́s on the basis of its cytotoxity and antileukemic activity, its structure was published in 1971 in a paper that has been cited 1000 times since this publication. The review focuses primarily on the interesting and novel chemistry of taxol that has been discovered over the last eight years.
The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. It is therefore not really surprising to find out that the list of contributing authors, who were awarded a Nobel Prize, is quite long: Kurt Alder, Derek H.R. Barton, George Wells Beadle, Dorothy Crowfoot-Hodgkin, Otto Diels, Hans von Euler-Chelpin, Paul Karrer, Luis Federico Leloir, Linus Pauling, Vladimir Prelog, with Walter Norman Haworth and Adolf F.J. Butenandt serving as members of the editorial board. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
The first contribution reviews the occurrence of xanthine alkaloids in the plant kingdom and the elucidation of the caffeine biosynthesis pathway, providing details of the N-methyltransferases, belonging to the motif B' methyltransferase family which catalyze three steps in the four step pathway leading from xanthosine to caffeine. The second contribution in this book provides a background on the molecule and related compounds and update knowledge on the most recent advances in Iboga alkaloids. The third contribution presents a comprehensive analysis of frequently occurring errors with respect to 13C NMR spectroscopic data and proposes a straightforward protocol to eliminate a high percentage of the most obvious errors.