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Ventricular arrhythmias cause most cases of sudden cardiac death, which is the leading cause of death in the US. This issue reviews the causes of arrhythmias and the promising new drugs and devices to treat arrhythmias.
At one time, heart disease was a death sentence. In The Heart Healers, world renowned cardiac surgeon Dr. James Forrester tells the story of the mavericks and rebels who defied the accumulated medical wisdom of the day to begin conquering heart disease. By the middle of the 20th century, heart disease was killing millions and, as with the Black Death centuries before, physicians stood helpless. Visionaries, though, had begun to make strides earlier. On Sept. 7, 1895, Ludwig Rehn successfully sutured the heart of a living man with a knife wound to the chest for the first time. Once it was deemed possible to perform surgery on the heart, others followed. In 1929, Dr. Werner Forssman inserted a cardiac catheter in his own arm and forced the x-ray technician on duty to take a photo as he successfully threaded it down the vein into his own heart...and lived. On June 6, 1944 - D-Day - another momentous event occurred far from the Normandy beaches: Dr. Dwight Harken sutured the shrapnel-injured heart of a young soldier, saved his life and the term "cardiac surgeon" born. Dr. Forrester tells the story of these rebels and the risks they took with their own lives and the lives of others to heal the most elemental of human organs - the heart. The result is a compelling chronicle of a disease and its cure, a disease that is still with us, but one that is slowly being worn away by "The Heart Healers".
Perfect for residents, generalists, anesthesiologists, emergency department physicians, medical students, nurses, and other healthcare professionals who need a practical, working knowledge of cardiology, Netter's Cardiology, 3rd Edition, provides a concise overview of cardiovascular disease highlighted by unique, memorable Netter illustrations. This superb visual resource showcases the well-known work of Frank H. Netter, MD, and his successor, Carlos Machado, MD, a cardiologist who has created clear, full-color illustrations in the Netter tradition. New features and all-new chapters keep you up to date with the latest information in the field. - Includes 13 all-new chapters: Basic Anatomy and Embryology of the Heart, Stem Cell Therapies for Cardiovascular Disease, Diabetes and Cardiovascular Events, Clinical Presentation of Adults with Congenital Heart Disease, Transcatheter Aortic Valve Replacement, Deep Vein Thrombosis and Pulmonary Embolism, and more. - Features new coverage of 3-D TEE imaging for structural heart procedures. - Contains color-coded diagnostic and therapeutic algorithms and clinical pathways. - Uses an easy-to-follow, templated format, covering etiology, pathogenesis, clinical presentation, diagnostic approach, and management/therapy for each topic. - Offers dependable clinical advice from Drs. George A. Stouffer, Marschall S. Runge, Cam Patterson, and Joseph S. Rossi, as well as many world-renowned chapter contributors.
Cardiac arrest can strike a seemingly healthy individual of any age, race, ethnicity, or gender at any time in any location, often without warning. Cardiac arrest is the third leading cause of death in the United States, following cancer and heart disease. Four out of five cardiac arrests occur in the home, and more than 90 percent of individuals with cardiac arrest die before reaching the hospital. First and foremost, cardiac arrest treatment is a community issue - local resources and personnel must provide appropriate, high-quality care to save the life of a community member. Time between onset of arrest and provision of care is fundamental, and shortening this time is one of the best ways to reduce the risk of death and disability from cardiac arrest. Specific actions can be implemented now to decrease this time, and recent advances in science could lead to new discoveries in the causes of, and treatments for, cardiac arrest. However, specific barriers must first be addressed. Strategies to Improve Cardiac Arrest Survival examines the complete system of response to cardiac arrest in the United States and identifies opportunities within existing and new treatments, strategies, and research that promise to improve the survival and recovery of patients. The recommendations of Strategies to Improve Cardiac Arrest Survival provide high-priority actions to advance the field as a whole. This report will help citizens, government agencies, and private industry to improve health outcomes from sudden cardiac arrest across the United States.
This textbook provides a comprehensive, yet practically orientated overview of classic and novel sports cardiology topics, based on current evidence, guidelines, recommendations and expert experience. Numerous publications have provided guidance to these issues, but it has become increasingly difficult for both students and doctors to obtain a thorough, but practicable overview for optimal clinical care of athletes and patients. This book is intended as an educational work, filling the large gaps that are still present in the current educational guidelines for medical students and cardiology trainees. Textbook of Sports and Exercise Cardiology differs from other sports cardiology books by focusing on clear, practical recommendations based on the latest evidence, primarily targeting those who seek professional background information and education that can easily be transferred into everyday care.
Presents diagnostic and therapeutic developments in the field of sudden cardiac death (SCD). Epidemiologic data is reviewed with emphasis on identifying risk factors and the relation of coronary heart disease to SCD. The book offers guidelines for pharmacologic and interventional treatment.
Sudden death in athletes is a global problem. Although it is a relatively rare phenomenon (1/100,000 persons), when it does occur, it is often as an incomprehensible event. In fact, it strikes subjects who presumably should be much healthier than the general population. In the previous 20 years, many authors have studied this problem in an attempt to understand the causes and prevent these events, and it has been determined that, in the vast majority of cases, athletes who die suddenly have an underlying heart disease (arrhythmogenic cardiomyopathy, hypertrophic cardiomyopathy, coronary anomalies, channelopathies, etc.). In most cases these diseases do not produce major symptoms and do not preclude sports activity even at the highest levels, although they do increase the incidence of sudden death. How to discover these diseases in asymptomatic athletes is a hotly debated issue. In particular, there is controversy as to whether all athletes should undergo detailed medical screening, including electrocardiogram, or whether the costs of this screening are too high in relation to the event incidence. The purpose of this book is to accurately analyze the causes of sudden death in athletes and to provide cardiologists and sports physicians with useful tips on how to identify at-risk individuals.
The unexpected death of an athlete during exercise is a tragic irony - albeit with a history dating back to Pheldippides, who collapsed after his original Marathon run. We are more apt to consider vigorous exercise as a protective measure against cardiovascular events and not as a triggering mechanism for them. The relative rarity of such episodes makes the screening of those at risk even more of a challenge. This challenge is well met in this unique text, the first to deal specifically, authoritatively, and comprehensively with the issues of prediction and prevention of sudden cardiac death in the athlete. Many of the underlying cardiovascular diseases that put athletes at risk are identified and explained, including: hypertrophic cardiomyopathy arrhythmogenic right venticular dysplasia Wolff-Parkinson-White Syndrome anomalous origin of the coronary arteries inherited long QT syndromes The screening guidelines are of particular value, as are the recommendations regarding the participation of athletes with cardiovascular disease. Beyond its clinical scope, the editors have incorporated current information in epidemiology, cardiovascular pathophysiology, and the many vexing legal and ethical issues. With its in-depth, multi-faceted approach and prominent contributors, Sudden Cardiac Death in the Athlete is sure to be a much welcomed reference for sports medicine and team physicians, athletic directors and trainers, family practitioners, pediatricians, and cardiologists.
This book dedicates the first seven chapters to cardiac electrophysiological dysfunction that can lead to ventricular fibrillation and sudden death. The next six chapters expand the topics of sudden death to other causes. Brugada Syndrome is the top cause of non-traumatic sudden death in young males of Southeastern Asian and southern European origins. Chapters One and Two review extensively the history and current status, mechanisms of arrhythmias, and related gene mutations in Brugada Syndrome, and discuss gaps in the current knowledge. Chapter Three presents clinical studies on the A1180V and R1193Q mutations of the cardiac sodium channel gene, SCN5A. The authors identified R1193Q mutation in 12.8%-16% of a healthy Chinese population. This result prompted the question of whether SCN5A mutations are still the top genetic bases of Brugada and long QT syndromes. Chapters Four, Five and Seven discuss the pathophysiology causes, risk factors, predictors, prevention, and possible therapeutical strategies of sudden cardiac death. Chapter Six reviews the scope and causes of sudden cardiac death in athletics.Chapter Seven is dedicated to the roles of electrical cardiac systole in sudden death. Chapter Eight reviews sudden death related to cardiac and brain tumours, pulmonary tumour embolism, asphyxia, massive exsanguinations, and their pathophysiology. Chapter Nine summarises the pathophysiology of sudden death caused by myocardial tuberculosis. Chapter Ten introduces pathophysiology of sudden death during hot baths in deep bathtubs, which occurs frequently in elderly people in Japan. Chapter Eleven discusses air pollution as a trigger of sudden death. Chapter Twelve presents biochemical, cytological and histopathological examination of sudden unexpected death in infancy. The last chapter of the book, Chapter Thirteen, reviews post-mortem cardiac markers in different body fluids and their application in forensic pathology diagnosis of sudden cardiac death. In combination, these chapters cover a broad range of topics about sudden death.
This is a detailed clinical compilation on sudden cardiac death causes. From the various geographical regions of the world comes different clinical perspectives toward the SCD problem that shed light on the predictors and estimated prevalence in genetic inheritance worldwide. For many centuries, the mysterious deaths of prominent professional sportsmen have preoccupied the attention of the media and medical professionals. In some cases, it was possible to obtain the medical histories of the victims, data on the presence of some specific diseases, and conditions or potential symptoms preceding the fatal episode. Various rare inherited syndromes that are associated with congenital heart disease are focused on in this study, and the interrelationship between ventricular premature beats, sustained/non-sustained ventricular tachycardias and ventricular fibrillations are discussed. Cardio-oncology is an emerging field where more and more patients face consequences from radiotherapy and chemotherapy because these individuals become more prone to SCD. Among the most notable developments, three-dimensional echocardiography and myocardial strain imaging are worth noting and might inexpensively improve the current risk stratification process. Recently, a strain that reflects the change of length and thickness of myocardial fibres has been incorporated into the routine clinical practice. The risk of sudden cardiac death is not the same in patients with Chagas disease, and newly predicted factors are to blame. The prevalence of SCD, hypertrophic cardiomyopathy and the accurate risk are extremely challenging, so much so that they recently became a source of argument between European and American experts. This is a must-have book for those interested in a clinical approach to the SCD phenomenon.