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Magnetic resonance spectroscopy (MRS) is a modality available on most clinical MR scanners and readily integrated with standard MR imaging (MRI). For the brain in particular, MRS has been a powerful research tool providing additional clinically relevant information for several disease families such as brain tumors, metabolic disorders, and systemic diseases. The most widely-available MRS method, proton (1H; hydrogen) spectroscopy, is FDA approved for general use in the US and can be ordered by clinicians for patient studies if indicated. There are several books available that describe applications of MRS in adults. However, to the best of our knowledge there is currently no book available that focuses exclusively on applications in pediatrics. MR spectroscopy in the pediatric population is different from adults for two main reasons. Particularly in the newborn phase the brain undergoes biochemical maturation with dramatic changes of the "normal" biochemical fingerprint. Secondly, brain diseases in the pediatric population are different from adult disorders. For example, brain tumors, which are mostly gliomas in the adults, often originate from different cell types and are also more diverse even within the same type and grade of tumor. This diversity of diseases and its implications for MR spectroscopy has not been addressed sufficiently in the literature, we believe. The target audience for "MR Spectroscopy of Pediatric Brain Disorders" are thus both clinicians and researchers involved with pediatric brain disorders. This includes radiologists, neurologists, neurooncologists, neurosurgeons, and more broadly the neuroscience and neurobiology community. This book will provide the necessary background information to understand the basics of MR spectroscopy. This will be followed by a detailed discussion of the normal biochemical maturation which will highlight the metabolic differences between the pediatric and adult brain. Thereafter, in SECTION I individual chapters will address various pediatric brain disease families. Of particular importance for pediatrics are case studies. For that reason, SECTION II will contain a large number of case studies. This will be particularly important for clinicians who may want to see examples of MRS for various conditions. A standardized format will be used for case reports that allow the reader to quickly understand the history of each case presented and the significance of the findings. The case reports will also include information from other imaging modalities to point out any added value of MRS in addition to conventional studies and clinical information. This section is necessary because the format of providing more complete information about individual patients is not practical for the chapters in SECTION I.
In recent years, research studies into sports injuries have provided healthcare professionals with a better understanding of their etiology and natural history. On this basis, novel concepts in the diagnosis and management of these conditions are now being explored. This timely book offers a complete guide to the latest knowledge on the diagnosis and treatment of the full range of possible sports injuries. Individual sections are devoted to biomechanics, injury prevention, and the still emerging treatment role of growth factors, which foster more rapid tissue healing. Sports injuries of each body region are then examined in detail, with special attention to diagnostic issues and the most modern treatment techniques. In addition, pediatric sports injuries, extreme sports injuries, the role of physiotherapy, and future developments are extensively discussed. All who are involved in the care of patients with sports injuries will find this textbook to be an invaluable, comprehensive, and up-to-date reference.
Brain Mapping: The Disorders is the first comprehensive text to describe the uses of the latest brain mapping technologies in the evaluation of patients with neurological, neurosurgical and psychiatric disorders. With contributions from the leading figures in the field, this heavily illustrated text is organized by disorders of brain systems, with specific examples of how one should use current neuroimaging techniques to evaluate patients with specific cerebral disorders. Comprehensive in scope, the text discusses patient evaluations using the wide range of modern magnetic resonance imaging techniques, positron emission tomography, single photon emission computed tomography, optical intrinsic signal imaging, electroencephalography, magnetoencephalography, and transcranial magnetic stimulation. The third in this brain mapping series, Brain Mapping: The Disorders, is the ultimate text for anyone interested in the use of brain mapping techniques to study patients with disorders of the central nervous system. - Provides a comprehensive, in-depth view of the current brain mapping techniques as they are used in the evaluation of patients with cerebral disorders - Heavily illustrated to provide actual examples of the use of the specific techniques - Includes contributions from the leaders in the field ensure authoritative and up-to-date material - Completes the trilogy of three brain mapping texts dealing, respectively, with the methods, the applications of these methods in the normal brain and in patients with neurological, neurosurgical, and psychiatric disorders
This book was written to provide a thorough overview of clinical nutrition and immunology to allow the reader to become knowledgeable in this evolving and complex area of medicine. The reader, whether a clinician, student, teacher, or researcher, will find this book comprehensive and up to date.The disease-specific chapters have been written to focus attention on novel approaches to nutrient-immune system interactions that affect specific diseases. This includes the identification of immunologic actions that can be influenced by nutrition. Specific nutrient chapters were written by experienced investigators to provide the reader with an understanding of the current role of nutrients in the immune system with both clinical and research applications. Throughout the book, the authors actively emphasize new frontiers for research and practical use of new findings in the fields of nutritional medicine and nutritional pharmacology.
A nonfictional inspirational story of the many experiences and lessons learned with its countless turns, trials and tribulations in my life. All this occurred while raising three children after a divorce and an absentee father. My journey grew to lead me into a deeper level of faith. I am blessed with the Gift of Discernment, Word of Knowledge and Healing, which brought me out of a religious environment into the awareness and understanding that our God is still alive The Lord sent me to pray over the wounded soldiers coming home from the current wars in Iraq and Afghanistan where healings and miracles abounded. The stories that you read will make you think twice if you have any doubt that there is a living God!
MRS of the Brain and Neurological Disorders illustrates and demonstrates the usefulness of magnetic resonance spectroscopy for the diagnosis of brain and neurological disorders, including epilepsy, nervous disorders, psychiatric disorders, and brain tumors. The book is unique in that it contains 87 case studies of neurologic and psychiatric diso
The Role of Selenium in Nutrition reviews the most pertinent scientific literature dealing with the basic aspects of the present understanding of the roles of selenium (Se) in nutrition and health. The book begins with a general discussion of Se, covering its various forms, chemistry and physical properties, and techniques for Se analysis. This is followed by separate chapters on the environmental aspects of Se, including its presence in mineral deposits, soils, water, air, and uptake by plants; Se contents of human foods and animal feedstuffs; biological utilization of dietary Se; and absorption, excretion, metabolism, and tissue concentrations of Se. Subsequent chapters deal with the biochemical functions of Se; Se-related diseases of animals and livestock; the role of Se in human health and in support of normal immune function and disease resistance; and the relationship of Se and cancer. The final chapter reviews the evidence concerning the toxicity of Se compounds and sets this in perspective with current knowledge of the roles of Se in nutrition and health, and of the normal exposures of animals and humans to Se compounds.