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Fully updated new edition covering all aspects of bone and joint diseases in one easily readable volume. Color illustrations throughout.
Preceded by: Clinical clerkship in inpatient medicine / Sanjay Saint. 3rd ed. c2010.
In recent years, the knowledge of how renal damage occurs in patients with plasma cell dyscrasias / myeloma has substantially increased. For the first time, this publication brings together issues relating to the diagnosis and pathogenesis of these disorders, as well as a summary of advances achieved in the treatment and management of patients. Several chapters are devoted to various glomerulopathies associated with deposition of immunoglobulin light and heavy chains, including those associated with amyloidosis. The sequential events are pointed out, crucial steps and key molecules open to modulation or control are delineated, and therapeutic advances are highlighted. Although the emphasis is on the management of cases with renal involvement, a distinct focus on the diseases as a whole and their impact on patients' general health and prognosis has been maintained throughout the discussions. Using a translational approach to renal manifestations in patients with plasma cell dyscrasias / myelomas, this publication conveys a comprehensive state-of-the-art view of the subject. It is aimed at practicing renal pathologists, nephrologists, internists and hematologists, as well as at trainees and scientists working in these specialties.
Cancer and the Kidney covers the challenging overlap area of nephrology and oncology, both in terms of kidney problems in cancer patients, and cancer that affects kidney patients, including assessment of kidney function, to paraneoplastic disorders, acquired cysts and native kidney cancers, and all points inbetween.
The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.
This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.
An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.
Kidney failure represents a major health economic burden for all people and all nations. Despite the immense number of factors which can cause the initial injury to the kidneys, common response pathways are triggered which, unless broken, will ultimately lead to irreversible fibrosis within the kidneys. Unfortunately, early injuries to the kidneys can frequently be asymptomatic and chronic kidney disease has often developed before the patient has become aware there is a problem. Once established, chronic kidney disease is associated with a high morbidity and mortality for those affected. There has been a large amount of work in recent years focused on the early diagnosis and management of kidney disease to prevent its progression. The purpose of this book is to review the mechanisms which underlie both acute and chronic kidney injury, discuss their diagnosis, complications and management. The first section of this book covers the causes and complications of chronic kidney disease. Initially we review the mechanisms which underlie the progressive fibrosis by which chronic kidney disease progresses. There are then detailed discussions of the cardiovascular complications of chronic kidney disease. The second section of the book focuses on established end stage renal disease. Reviewing access to renal replacement therapies across ethnicities, the role of home therapies and how their use can be increased and finally we discuss the preparation and maintenance of access for dialysis. The third and final section of the book provides an update for the clinician into the diagnosis and management of acute kidney injury. Specifically the diagnosis and management of renal impairment in patients with plasma cell dyscrasias is reviewed and the prevention of acute kidney injury in the critically ill patient is discussed in detail.
Written by a team of world renowned renal pathologists, this book provides a compact and up-to-date resource. Beginning with the basic concepts and methods in renal pathology, the text covers renal anatomy, including gross and miscroscopic appearance and pathogenic mechanisms in renal diseases. Emphasizing clinical pathological correlation and differential diagnosis, the handbook discusses glomerular disease, systemic diseases, vascular diseases, rejection and much more. 107 photographs (84 in color).