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Designed for use as a self-study text, as a course text in more formal instruction programs, or as a refresher for the busy professional, the book includes valuable background data on legal and regulatory issues, as well as pharmaceutical technology.
Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting clinical trials with the goal of improving the evidence derived from these important studies This Third Edition builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials. Readers will encounter the principles of design for various types of clinical trials, and are then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides common sense solutions. All stages of therapeutic development are discussed in detail, and the methods are not restricted to a single clinical application area. The authors bases current revisions and updates on his own experience, classroom instruction, and feedback from teachers and medical and statistical professionals involved in clinical trials. The Third Edition greatly expands its coverage, ranging from statistical principles to new and provocative topics, including alternative medicine and ethics, middle development, comparative studies, and adaptive designs. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First and Second Editions will discover revamped exercise sets; an updated and extensive reference section; new material on endpoints and the developmental pipeline, among others; and revisions of numerous sections. In addition, this book: • Features accessible and broad coverage of statistical design methods—the crucial building blocks of clinical trials and medical research -- now complete with new chapters on overall development, middle development, comparative studies, and adaptive designs • Teaches readers to design clinical trials that produce valid qualitative results backed by rigorous statistical methods • Contains an introduction and summary in each chapter to reinforce key points • Includes discussion questions to stimulate critical thinking and help readers understand how they can apply their newfound knowledge • Provides extensive references to direct readers to the most recent literature, and there are numerous new or revised exercises throughout the book Clinical Trials: A Methodologic Perspective, Third Edition is a textbook accessible to advanced undergraduate students in the quantitative sciences, graduate students in public health and the life sciences, physicians training in clinical research methods, and biostatisticians and epidemiologists. This book is accompanied by downloadable files available below under the DOWNLOADS tab. These files include: MATHEMATICA program – A set of downloadable files that tracks the chapters, containing code pertaining to each. SAS PROGRAMS and DATA FILES used in the book. The following software programs, included in the downloadables, were developed by the author, Steven Piantadosi, M.D., Ph.D: RANDOMIZATION – This program generates treatment assignments for a clinical trial using blocked stratified randomization. CRM – Implements the continual reassessment methods for dose finding clinical trials. OPTIMAL – Calculates two-stage optimal phase II designs using the Simon method. POWER – This is a power and sample size program for clinical trials. Executables for installing these programs can also be found at https://risccweb.csmc.edu/biostats/. Steven Piantadosi, MD, PhD, is the Phase One Foundation Distinguished Chair and Director of the Samuel Oschin Cancer Institute, and Professor of Medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Piantadosi is one of the world’s leading experts in the design and analysis of clinical trials for cancer research. He has taught clinical trials methods extensively in formal courses and short venues. He has advised numerous academic programs and collaborations nationally regarding clinical trial design and conduct, and has served on external advisory boards for the National Institutes of Health and other prominent cancer programs and centers. The author of more than 260 peer-reviewed scientific articles, Dr. Piantadosi has published extensively on research results, clinical applications, and trial methodology. While his papers have contributed to many areas of oncology, he has also collaborated on diverse studies outside oncology including lung disease and degenerative neurological disease.
As a former private investigator and forensic writer, Joe Nickell has spent much of his career identifying forged documents, working undercover to infiltrate theft rings, and investigating questioned deaths. Now he turns his considerable investigative skill toward the paranormal, researching the most well-known and mysterious phenomena all over the world—spontaneous human combustion, UFO visitations, auras, electronic poltergeists, and many, many more—with an eye toward solving these mysteries rather than promoting or dismissing them. Real-Life X-Files: Investigating the Paranormal examines the cases of over forty paranormal mysteries. Using a hands-on approach, Nickell visits the scene of the so-called unexplainable activity whenever possible and attempts to physically duplicate the miraculous. Whether he's inflicting stigmata on himself or recreating the liquefying blood of Saint Januarius, Nickell does whatever necessary to eliminate the probable before considering the supernatural. What is left is that much more fascinating. Nickell reports on familiar legends from American history such as the supernatural events surrounding Abraham Lincoln's death and the supposed crash landing of an alien spacecraft near Roswell, New Mexico. He closely examines claims of the miraculous, from rose petals bearing the likeness of Jesus to photographs of a "golden door" to heaven. Controversial mysteries such as clairvoyance and "spirit painting," haunted places, and freaks of nature are just a few of the many topics covered. Suspenseful, engrossing, funny, and grounded in scientific methodology, Real-Life X-Files provides real explanations for the "paranormal" activities that have intrigued human beings for centuries.
As our earliest ancestors migrated out of Africa, they encountered entirely new floras. By sampling these, they found plants that appeared to (and sometimes did) heal wounds, cure maladies, and ease troubled minds. This process of discovery continues today, as multinational pharmaceutical companies bioprospect in the globe's remaining wild places for the next tamoxifen or digitalis. The gardener and botanist David Stuart tells the fascinating story of botanical medicine, revealing more than soothing balms and heroic cures. Most of the truly powerful and effective medicinal plants are double-edged, with a dark side to balance the light. They can heal or kill, calm or enslave, lift depression or summon our gods and monsters. Often the difference between these polar effects is a simple change in dosage. Stuart chronicles the tale of how the herbal materia medica of healing and killing plants has sparked wars, helped establish intercontinental trade routes, and seeded fortunes. As plant species traveled the globe, their medicinal uses evolved over miles and through centuries. Plants once believed to be cure-alls are now considered too dangerous for use. Others, once so valuable that they sowed the wealth of empires, are merely spices on the kitchen shelf. David Stuart recounts engrossing human stories too, not only of the scientists, explorers, and doctors who gathered, named, and prescribed these plants but also the shamans, magicians, and quacks who claimed to possess the ultimate herbal aphrodisiac or elixir.
Learn to identify Internet-based complementary/alternative medicine resources you can trust! This well-organized book takes a commonsense approach to getting the most out of the Internet when it comes to finding reliable information on complementary and alternative medicine. Author Lillian Brazin teaches classes on finding and evaluating health information on the Internet. In this book, she shares her years of experience in using and evaluating medical Internet sites to teach you to spot authoritative resources and avoid misinformation, sales pitches, and out-and-out quackery. In addition to showing you where to find the information you need, this book stresses the importance (the how and why) of working closely with your physician to get the best results from your complementary/alternative medical experience. More than 20 screen shot illustrations give you a preview of what to look for on various sites! The Guide to Complementary and Alternative Medicine on the Internet will show you how to separate the wheat from the chaff when confronted with hundreds of Web sites purporting to provide reliable information. This jargon-free book addresses vital questions, such as: How can I be certain that the information I find is correct? How can I locate a Web site that was recommended to me? How do I start out to research a particular health problem? What do Internet terms like .com, .edu, .gov, listservs, :), BTW, LOL, flames, netiquette, etc. mean? This book will also help you understand controversial hot topics that include: the Pilates exercise method that Jacqueline Kennedy Onassis helped popularize in the 1960s is trendy again, with Pilates studios in most major cities supermarket supplements, such as St. John's wort, gingko biloba, and vitamins A-Z: how can I find out which, if any of them, are for me? the validity of celebrity endorsements for supplements and alternative therapies While providing you with the skills to find the information you seek, this book reflects the author’s cautious perspective. The Internet can be frightening and overwhelming because there is so much information to sift through, digest, and evaluate. The Guide to Complementary and Alternative Medicine on the Internet (first in the new Internet Guides to Consumer Health Care series from The Haworth Information Press) will help you identify Internet resources for complementary and alternative medicine that you can trust.
Healthcare Online For Dummies empowers you to search the vast, sometimes confusing, resources of the Internet and find the medical information you need. The Internet and this book won't replace doctors, but Healthcare Online For Dummies will enable you to become an informed partner with your healthcare provider. This book includes sections on online search techniques, wellness, and major illnesses. An extensive directory of health and medical sites lists many of the best sites the Web has to offer.
Presents classic and recent findings on immunological dysfunctions caused by food allergies-coordinating the most advanced clinical techniques and assessment methods with practical insights for treatment and patient care.
This volume explores the different dimensions of how the contingency of life, and especially human life, is relevant for ethical discussions and the normative frameworks in bioethics. It explores the relevance of the notion contingency, needs and desires for moral argumentation and bioethics. The volume discusses those notions in a philosophical perspective. Additionally, the volume is a contribution to a deeper reflection on basic philosophical assumptions of bioethics.
Consumer Health: Making Informed Decisions is a concise, current text with the most up-to-date information about health care reform and insurance. It is devoted to the most important issues relative to consumer health issues, including advertising, dietary supplements, herbal remedies, weight management, and medications. There are in-depth analyses of the American health care system, insurance options, and consumer protection. The text also takes a critical look at complementary and alternative therapies. Throughout the text, there are guidelines for making decisions that can benefit the individual. A comprehensive list of learning objectives precede each chapter and a list of study questions conclude each chapter. The questions are designed to help the student summarize the major points of the chapter, prepare for exams, and critically analyze the material contained in the chapters. Instructor Resources: PowerPoint Presentations