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This book is an up-to-date compilation of chromosome findings on bone and soft tissue tumors. The book indicates the specificity of these changes and their relation to distinct pathologic entities. It also emphasizes the use of cytogenetic findings as part of the diagnostic approach for these tumors and as a guide for molecular biologists searching for the specific gene involved. Each chapter contains a comprehensive summary of the pathology of the tumors, particularly those in which cytogenetic findings have been published. This book will be valuable to pathologists, oncologists, and surgeons dealing with tumors of bone and soft tissue.
Review of orthopaedic oncology with case presentations illustrating how each tumor would be diagnosed and managed in a clinical setting.
Fine-needle aspiration cytology (FNAC) has been commonly used to follow up on previously treated sarcomas or to confirm soft tissue and bone metastases of carcinomas, melanomas or lymphomas. Its role as the first-line approach in the diagnosis of primary soft tissue and bone tumors has increased due to progress of less invasive diagnostic procedures and the growing availability of diagnostic ancillary tests. This comprehensive and richly-illustrated volume presents cytomorphology of all common neoplastic soft tissue and bone lesions but also of rare tumors largely described in case reports. Key points for cytological features, differential diagnosis, and the use of ancillary tests are discussed and illustrated in order to facilitate the diagnostic work-up in FNA samples. The volume is organized on the basis of the most recent WHO classification used in surgical pathology in order to provide a practical guide for modern cytologic diagnosis of surgical soft tissue and bone pathology. It is aimed mainly at surgical pathologists and cytopathologists, but also at orthopedic surgeons and clinical oncologists.
This book comprehensively covers modern soft tissue pathology and includes both tumors and non-neoplastic entities. Soft tissues make up a large bulk of the human body, and they are susceptible to a wide range of diseases. Many soft-tissue tumors are biologically very aggressive, and the chance of them metastasizing to vital organs is quite high. In recent years, the outlook for soft-tissue cancers has brightened dramatically due to the increased accuracy of the pathologist's tools. All methods of diagnosis are covered here, with an emphasis on the newest immunoassays and other genetic, molecular, and immunologic diagnostic modalities. This book's systematic description of benign and malignant primary soft tissue tumors with didactic, comprehensive panels of illustrations allows the reader to formulate a complete understanding of the morphology of tumor entities at one glance. The book covers both the most common tumor entities and more unusual diseases using more than 1,500 color images, making it a resource for beginning and senior pathologists.
The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date Now produced in full color for enhanced clarity Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible
This is an extraordinary book by an extraordinary author. Mario Campa nacci first published three volumes on musculoskeletal neoplasms and other tu mor-like processes in hone and soft parts in Italian in 1981-1985. This book is an update and expansionofthat book, published for the firsttime in English. In this book Dr. Campanacci brings to the readers the vast experience in musculoskel etal oncology of the Rizzoli Orthopaedic Institute in Bologna where he has been head of the Oncology Unit for many years. As such, he has had at his disposal the patient records, radiographs and pathologic material dating back to 1905. In fact, a visitor to the Institute will be shown the radiograph made of the first tumor case on records-that of a giant cell tumor of the distal femur. The wealth of cli nical material that has accumulated at the Rizzoli Institute, with exquisite docu mentation and maintenance is a unique resource and testimonial to not only the author but his predecessors. Under Dr. Campanacci's leadership, the Institute has provided care to the majority of patients with neoplasms throughout Italy. Over the past two decades a treatment team with extraordinary ability in radi ology, imaging, pathology, chemotherapy, as well as orthopedic surgery has been assembled.
Here's your ideal reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. No other textbook matches its scope and depth of coverage in this complex and challenging area of surgical pathology, and no other text contains as much practical information on differential diagnosis. Throughout, microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry to provide you with a comprehensive and integrated approach to evaluation and diagnosis. Almost 2,000 superb illustrations capture the appearance of a complete range of entities and help relate these to their specific classifications. The result is an essential resource for all who diagnose and treat soft tissue tumors. Get all the assistance you need, in one reference, to effectively diagnose these often complex and challenging entities. Confirm your diagnostic suspicions by comparing your findings to nearly 2,000 full-color, high-quality illustrations representing the complete range of soft tissue tumors. Access all of the essential clinical and prognostic data necessary to formulate complete sign-out reports. Make optimal use of relevant ancillary techniques such as immunohistochemistry and cytogenetics. Make rapid and effective decisions with the aid of extensive algorithms, and access information at a glance with abundant tables and graphs. Solve difficult diagnostic dilemmas and avoid pitfalls with a special emphasis on overcoming these challenges. Find answers quickly thanks to a new color-coded page design as well as a consistent approach to every entity. Download all of the illustrations from the book for use in electronic presentations with the new bonus CD-ROM. Apply the latest knowledge on FNA biopsy, molecular biology, and cytogenetics. Understand complex molecular events more fully thanks to new conceptual line drawings. Easily distinguish between entities that have a similar appearance with the assistance of new tables that correlate histologic, immunohistochemical, and molecular biologic findings. Navigate through the book quickly thanks to new summary outlines at the beginning of each chapter.
Only with the advent of computed tomography and magnetic resonance imaging have radiologists become familiar with this uncommon pathology. The emphasis here is on MRI, as it guarantees the most accurate diagnosis of soft tissue tumours. Because of their rarity, multi-centric studies are necessary to collect statistically relevant numbers of these tumours and so assess the value of new imaging techniques in their detection, staging, grading, tissue characterisation, and post-treatment follow-up. This is a reflection of the work of a prestigious European study group of more than 30 such co-investigators - including experts on medical imaging - who collected more than 800 documented and histologically proven cases of soft tissue tumours. For each tumour type, 10-12 cases are shown, supported by 3-4 photos. Unsurpassed in its collection of case studies.