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Vaccines have saved more lives than any other single medical advance. Yet today only four companies make vaccines, and there is a growing crisis in vaccine availability. Why has this happened? This remarkable book recounts for the first time a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, thathas led many pharmaceutical companies to abandon vaccine manufacture. Drawing on interviews with public health officials, pharmaceutical company executives, attorneys, Cutter employees, and victims of the vaccine, as well as on previously unavailable archives, Dr. Paul Offit offers a full account of the Cutter disaster. He describes the nation's relief when the polio vaccine was developed by Jonas Salk in 1955, the production of the vaccine at industrial facilities such as the one operated by Cutter, and the tragedy that occurred when 200,000 people were inadvertently injected with live virulent polio virus: 70,000 became ill, 200 were permanently paralyzed, and 10 died. Dr. Offit also explores how, as a consequence of the tragedy, one jury's verdict set in motion events that eventually suppressed the production of vaccines already licensed and deterred the development of new vaccines that hold the promise of preventing other fatal diseases.
In the early years of the twentieth century, Spokane was singled out for praise in the West for the quality of its architecture and the impressive way it had rebuilt after the devastating fire of 1889. Major credit for the city's distinctive character was extended to Kirtland Kelsey Cutter for his "rare architectural force and genius for design." His remarkable career, stretching from the Gilded Age to the Great Depression, allows a fascinating study of the evolution of an eclectic form of architecture that was an inevitable response to rich regional and historical influences during a time of transition from frontier settlements to modern city. Cutter's influence was felt beyond Spokane--in Seattle, other areas of Washington, and in Oregon, Idaho, and Montana. He was also responsible for buildings in the East and even for one in England. After financial problems ended his career in the Northwest, he began anew at age sixty-three in southern California, and worked there as an architect until his death in 1939 at age seventy-nine. Henry Matthews presents a comprehensive study of the whole body of Cutter's work, with ample photographs and illustrations. The book is based on exhaustive research in both the Northwest and California, revealing the influences on Cutter and his associates, the processes at work in the design and construction of the buildings, and the relations between the architect and the many people who commissioned his work. Particularly useful to Matthews's research was a collection of 290 sets of drawings, as well as office accounts, letters, and books from Cutter's library--materials acquired by the Eastern Washington State Historical Society. He also was able to interview former assistants and clients, who provided valuable insights on the architect and the way Cutter worked. In addition, many of the architect's residences, hotels, clubs, and commercial buildings are still standing. This book adds significantly to an understanding of Western urban and regional history. But Cutter's experimentation in many styles and the imaginative nature of his work make for a study that goes beyond regional limits and sheds light on national trends. Winner of the 1999 Washington State Book Award
“A thriller, and a whacking good thriller, too . . . shows how much can be done within a classic form by a writer who knows his business.”—The New York Times Alex Cutter is a scarred and crippled Vietnam veteran, obsessed with a murder he’s convinced his buddy, Richard Bone, witnessed. That it was committed by the powerful tycoon JJ Wolfe only makes Cutter even surer that Bone saw the unthinkable. Captivated by Cutter’s demented logic, Bone is prepared to cross the country with Cutter in search of proof of the murder. Their quest takes them into the Ozarks—home base of the Wolfe empire—where Bone discovers that Cutter is pursuing both a cold-blooded killer, but also an even bigger and more elusive enemy. “Tense, funny, and despairing . . . charged with a passion that makes even grotesques seem likeable and, more important, credible right up to the last, startling sentence.”—Time “May be the quintessential cult crime classic . . . continues to be cited by other writers as groundbreaking . . . The ending is pure Chinatown, with a dose of Easy Rider, and it leaves us reeling.”—Booklist (starred review) Praise for Newton Thornburg “A commanding writer of unusual delicacy and power.”—The New Yorker “A born storyteller.”—St. Louis Post-Dispatch “One of the truly great American writers of the 20th century.”—The Guardian
Join Connor the Courageous Cutter in his first adventure in beautiful Serendipity Sound. When Sarah the Schooner gets caught in a storm, panic riddles the sound. Who will heed the Harbor Master's call and save her?
A trio of mismatched mercenaries is hired by a young woman to evaluate the safety of a boy who may have been taken against his will to a New Mexico backwoods settlement, where the mercenaries encounter paranoia, mistrust, and insanity in the shadow of a monolithic idol.
WINNER OF THE JAMES HERBERT AWARD FOR HORROR WRITING “The Troop scared the hell out of me, and I couldn’t put it down. This is old-school horror at its best.” —Stephen King Once every year, Scoutmaster Tim Riggs leads a troop of boys into the Canadian wilderness for a weekend camping trip—a tradition as comforting and reliable as a good ghost story around a roaring bonfire. But when an unexpected intruder stumbles upon their campsite—shockingly thin, disturbingly pale, and voraciously hungry—Tim and the boys are exposed to something far more frightening than any tale of terror. The human carrier of a bioengineered nightmare. A horror that spreads faster than fear. A harrowing struggle for survival with no escape from the elements, the infected…or one another. Part Lord of the Flies, part 28 Days Later—and all-consuming—this tightly written, edge-of-your-seat thriller takes you deep into the heart of darkness, where fear feeds on sanity…and terror hungers for more.