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A Jew who left Germany when Hitler came to power, Sir Ernst Chain was a winner, with Sir Alexander Fleming and Lord Florey, of the Nobel Prize for Physiology and Medicine in 1945. Later he was a significant figure in the use of the semi-synthetic penicillins which, from the mid-1950s onwards, revolutionized the use of the anti­biotic in more than one field of medicine. Born in Berlin in 1906, of a Russian emigre father and a German mother, Chain left Germany for England on 30 January 1933. Working first with Sir Frederick Gowland Hopkins in Cambridge, then with Professor Howard Florey in Oxford, Chain studied the biochemical processes by which bacteriolytic agents operate. Writing up his results, he studied Fleming's neglected original report of the bacteria-inhibiting properties of penicillin, and with Florey's support embarked on a major investigation of how penicillin could be made and purified.
This penetrating case study of institution building and entrepreneurship in science shows how a minor medical speciality evolved into a large and powerful academic discipline. Drawing extensively on little-used archival sources, the author analyses in detail how biomedical science became a central part of medical training and practice. The book shows how biochemistry was defined as a distinct discipline by the programmatic vision of individual biochemists and of patrons and competitors in related disciplines. It shows how discipline builders used research programmes as strategies that they adapted to the opportunities offered by changing educational markets and national medical reform movements in the United States, Britain and Germany. The author argues that the priorities and styles of various departments and schools of biochemistry reflect systematic social relationships between that discipline and biology, chemistry and medicine. Science is shaped by its service roles in particular local contexts: This is the central theme. The author's view of the political economy of modern science will be of interest to historians and social scientists, scientific and medical practitioners, and anyone interested in the ecology of knowledge in scientific institutions and professions.
First multi-year cumulation covers six years: 1965-70.
Reference book comprising a bibliography aiming to bring together secondary source interdisciplinary material on labour relations in the UK between the years 1880 and 1970 - covers employees attitudes, trade unions and employees associations, employers organizations, the labour market and working conditions, etc.
Considered 'the father of genomics', Fred Sanger (1918–2013) paved the way for the modern revolution in our understanding of biology. His pioneering methods for sequencing proteins, RNA and, eventually, DNA earned him two Nobel Prizes. He remains one of only four scientists (and the only British scientist) ever to have achieved that distinction. In this, the first full biography of Fred Sanger to be published, Brownlee traces Sanger's life from his birth in rural Gloucestershire to his retirement in 1983 from the Medical Research Council's Laboratory of Molecular Biology in Cambridge. Along the way, he highlights the remarkable extent of Sanger's scientific achievements and provides a real portrait of the modest man behind them. Including an extensive transcript of a rare interview of Sanger by the author, this biography also considers the wider legacy of Sanger's work, including his impact on the Human Genome Project and beyond.
This biographical brief outlines the remarkable life and career of British biochemist, Marjory Stephenson (1885-1948). In nine concise chapters, Štrbáňová describes Stephenson's scientific accomplishments and sets these against the socio-political challenges of the time. Stephenson played an important role in the development of biochemistry and molecular biology. She was one of the first scientists to use microorganisms as models for research into cellular biochemical processes and their regulation. Later she went on to coin the term chemical microbiology, which was communicated in her monograph and textbook "Bacterial Metabolism" (1930-1949). Stephenson also actively participated in the establishment of the institutionalized interdisciplinary field of general microbiology which integrated research into diverse forms of microorganisms at various levels of organization. Alongside these scientific achievements, Štrbáňová outlines Stephenson's constant battle with practices of undeclared discrimination, her important role as one of the first women science managers and organizers, and her influential position within the scientific community. A scientist of great merit and a role model to women scientists of all disciplines, the life of Marjory Stephenson is of interest to biochemists, molecular biologists, historians of the chemical and biological sciences, and women scientists of all generations.