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In today’s world, responsible biocitizenship has become a new way of belonging in society. Individuals are expected to make “responsible” medical choices, including the decision to be screened for genetic disease. Paradoxically, we have even come to see ourselves as having the right to be responsible vis-à-vis the proactive mitigation of genetic risk. At the same time, the concept of genetic disease has become a new and powerful way of defining the boundaries between human groups. Tay-Sachs, an autosomal recessive disorder, is a case in point—with origins in the period of Eastern European Jewish immigration to the United States and United Kingdom that spanned the late nineteenth and early twentieth centuries, it has a long and fraught history as a marker of Jewish racial difference. In Testing Fate, Shelley Z. Reuter asks: Can the biocitizen, especially one historically defined as a racialized and pathologized Other, be said to be exercising authentic, free choice in deciding whether to undertake genetic screening? Drawing on a range of historical and contemporary examples—doctors’ medical reports of Tay-Sachs since the first case was documented in 1881, the medical field’s construction of Tay-Sachs as a disease of Jewish immigrants, YouTube videos of children with Tay-Sachs that frame the disease as tragic disability avoidable through a simple genetic test, and medical malpractice suits since the test for the disease became available—Reuter shows that true agency in genetic decision-making can be exercised only from a place of cultural inclusion. Choice in this context is in fact a kind of unfreedom—a moral duty to act that is not really agency at all.
In the fifty years since DNA was discovered, we have seen extraordinary advances. For example, genetic testing has rapidly improved the diagnosis and treatment of diseases such as Huntington's, cystic fibrosis, breast cancer, and Alzheimer's. But with this new knowledge comes difficult decisions for countless people, who wrestle with fear about whether to get tested, and if so, what to do with the results. Am I My Genes? shows how real individuals have confronted these issues in their daily lives. Robert L. Klitzman interviewed 64 people who faced Huntington's Disease, breast and ovarian cancer, or Alpha-1 antitrypsin deficiency. The book describes--often in the person's own words--how each has wrestled with the vast implications that genetics has for their lives and their families. Klitzman shows how these men and women struggle to make sense of their predicament and its causes. They confront a series of quandaries--whether to be tested; whether to disclose their genetic risks to parents, siblings, spouses, offspring, friends, doctors, insurers, employers, and schools; how to view and understand themselves and their genetics; what treatments, if any, to pursue; whether to have children, adopt, screen embryos, or abort; and whether to participate in genetic communities. In the face of these uncertainties, they have tried to understand these tests and probabilities, avoid fatalism, anxiety, despair, and discrimination, and find hope, meaning, and a sense of wholeness. Forced to wander through a wilderness of shifting sands, they chart paths that many others may eventually follow. Klitzman captures here the voices of pioneers, some of the first to encounter the personal dilemmas introduced by modern genetics. Am I My Genes? is an invaluable account of their experience, one that will become all the more common in the coming years. "An extraordinary exploration...probing the many roles and implications of genetics in our lives today.... Filled with astonishing insights, this riveting book is vital reading for us all." --Paula Zahn "Klitzman lucidly discusses the moral and psychological complexities that come in the wake of genetic testing.... An important book for anyone who has the genes for pathology, which is all of us, and I recommend it highly." --Kay Redfield Jamison, author of An Unquiet Mind "An illuminating voyage through the medical, familial and existential quandaries faced by those of us at genetic risk." --Thomas H. Murray, President and CEO, The Hastings Center
The second book in the of Fate series, Test of Fate, continues the story of Evan Masters and Carla Jean C.J. MacFarlane. Set two years after Miracle of Fate, this novel follows Evan and C.J. continuing to explore life together as a couple very much in love. They decide to start a charitable foundation to broaden their reach and give back some of the good fortune they share. Not having any real experience in the non-profit arena, they hire a young woman named Jennifer Truman to run the foundation. Decisions about their future come to the forefront as C.J. struggles with Evan's desire to have children. With Evan at her side, she continues to search for her true place in the world. Filled with romance, drama, suspense and humor, Test of Fate allows the reader greater insight into Evan and C.J. as captivating, yet very much human, characters. When their relationship is subjected to the ultimate test, will their love be enough to survive?
Wexler tells the story of a family at risk for Huntington's disease, a hereditary, incurable, fatal disorder from which her own mother died. This graceful and eloquent account goes beyond the specifics of the disease to explore the dynamics of family secrets, of living at risk, and the drama and limits of biomedical research. Photos.
Nothing burns as bright as the flames of the refiner's fire. Moments after hearing the Council sentence her enemy to life imprisonment for attempted murder and illegal use of magic, Darcy is whisked away by the Fates-accused of tampering with destiny. The cherished dream she shared with Mason has been called into question, placing doubt about whether they are actually true mates. To resolve it, a price must be paid-the Heart or Death-a grueling series of tests designed to reveal a person's worth. The stakes are high and Darcy finds herself facing the unknown in conditions that leave her more vulnerable than she's ever been. Separated from Mason and her Pack, with Devlin as her only companion, she is pushed to her very limits. She must succeed-or lose everything. Will she crumble under the pressure or emerge stronger for testing fate?
From housewives to students and high-ranking officials, people from all social backgrounds in China and Taiwan visit fate calculation masters to learn about their destiny. How do clients assess the diviner’s skills? How does one become a fortune-teller? How is a person’s fate calculated? The Art of Fate Calculation explores how conceptions of fate circulate in Chinese and Taiwanese societies while resisting uniformization and institutionalization. This is not only due to the stigma of “superstition” but also to the internal dynamic of fate calculation practice and learning.
A major new book overturning our assumptions about how evolution works Earth’s natural history is full of fascinating instances of convergence: phenomena like eyes and wings and tree-climbing lizards that have evolved independently, multiple times. But evolutionary biologists also point out many examples of contingency, cases where the tiniest change—a random mutation or an ancient butterfly sneeze—caused evolution to take a completely different course. What role does each force really play in the constantly changing natural world? Are the plants and animals that exist today, and we humans ourselves, inevitabilities or evolutionary flukes? And what does that say about life on other planets? Jonathan Losos reveals what the latest breakthroughs in evolutionary biology can tell us about one of the greatest ongoing debates in science. He takes us around the globe to meet the researchers who are solving the deepest mysteries of life on Earth through their work in experimental evolutionary science. Losos himself is one of the leaders in this exciting new field, and he illustrates how experiments with guppies, fruit flies, bacteria, foxes, and field mice, along with his own work with anole lizards on Caribbean islands, are rewinding the tape of life to reveal just how rapid and predictable evolution can be. Improbable Destinies will change the way we think and talk about evolution. Losos's insights into natural selection and evolutionary change have far-reaching applications for protecting ecosystems, securing our food supply, and fighting off harmful viruses and bacteria. This compelling narrative offers a new understanding of ourselves and our role in the natural world and the cosmos.
LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLY Working in the laboratory or office, you use a diverse assortment of basic information to design, conduct, and interpret toxicology studies and to perform risk assessments. The Second Edition of the best-selling Handbook of Toxicology gives you the information you need in a single referen
Nothing burns as bright as the flames of the refiner's fire.Moments after hearing the Council sentence her enemy to life imprisonment for attempted murder and illegal use of magic, Darcy is whisked away by the Fates--accused of tampering with destiny. The cherished dream she shared with Mason has been called into question, placing doubt about whether they are actually true mates. To resolve it, a price must be paid--the Heart or Death--a grueling series of tests designed to reveal a person's worth.The stakes are high and Darcy finds herself facing the unknown in conditions that leave her more vulnerable than she's ever been. Separated from Mason and her Pack, with Devlin as her only companion, she is pushed to her very limits. She must succeed--or lose everything.Will she crumble under the pressure or emerge stronger for testing fate?