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This edition of Advances in Neurobiology brings together experts in the emerging field of Systems Neuroscience to present an overview of this area of research. Topics covered include: how different neural circuits analyze sensory information, form perceptions of the external world, make decisions, and execute movements; how nerve cells behave when connected together to form neural networks; the relationship between molecular and cellular approaches to understanding brain structure and function; the study of high-level mental functions; and studying brain pathologies and diseases with Systems Neuroscience. A hierarchy of biological complexity arises from the genome, transcriptome, proteome, organelles, cells, synapses, circuits, brain regions, the whole brain, and behaviour. The best way to study the brain, the most complex organ in the body composed of 100 billion cells with trillions of interconnections, is with a Systems Biology approach. Systems biology is an inter-disciplinary field that focuses on complex interactions within biological systems to reveal 'emergent properties' - properties of cells and groups of cells functioning as a system whose actual and theoretical description is only possible using Systems Biology techniques.
Explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition. In order to model neuronal behavior or to interpret the results of modeling studies, neuroscientists must call upon methods of nonlinear dynamics. This book offers an introduction to nonlinear dynamical systems theory for researchers and graduate students in neuroscience. It also provides an overview of neuroscience for mathematicians who want to learn the basic facts of electrophysiology. Dynamical Systems in Neuroscience presents a systematic study of the relationship of electrophysiology, nonlinear dynamics, and computational properties of neurons. It emphasizes that information processing in the brain depends not only on the electrophysiological properties of neurons but also on their dynamical properties. The book introduces dynamical systems, starting with one- and two-dimensional Hodgkin-Huxley-type models and continuing to a description of bursting systems. Each chapter proceeds from the simple to the complex, and provides sample problems at the end. The book explains all necessary mathematical concepts using geometrical intuition; it includes many figures and few equations, making it especially suitable for non-mathematicians. Each concept is presented in terms of both neuroscience and mathematics, providing a link between the two disciplines. Nonlinear dynamical systems theory is at the core of computational neuroscience research, but it is not a standard part of the graduate neuroscience curriculum—or taught by math or physics department in a way that is suitable for students of biology. This book offers neuroscience students and researchers a comprehensive account of concepts and methods increasingly used in computational neuroscience. An additional chapter on synchronization, with more advanced material, can be found at the author's website, www.izhikevich.com.
Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. - Knowledge covering the whole life span from early to later life - Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience - Understanding the neurobiology of major depressive disorder - Integrating stress and environmental factors with molecular underpinnings - More than 25 illustrations and tables
Systems Neuroscience is a compilation of interdisciplinary contributions to systems neuroscience — an approach within neuroscience that connects system theory and computer simulation. The compendium contains papers that discusses and elaborates a diverse range of studies in systems neuroscience. The topics in the book include the psychophysical data on human visual perception and memory, and indicates the value of a top-down analysis in relating quantitative measurements of human behavior to the fine-level analysis of the neurophysiology; computer analysis of a neural model of masking and flicker fusion; studies on the properties of differential equations that represent networks of neurons; the development of an interactive computer graphics language for the simulation of concurrent processes such as those occurring in neural networks; and the data structures for internal representations of spatial dimensions in the brain. The book will be a good source of valuable insight for neuroscientists.
The Brain: A Systems Neuroscience Perspective is a comprehensive textbook designed for undergraduate students in neuroscience. It offers a detailed exploration of brain dynamics, spatial navigation, and the neuroscience of Alzheimer's disease, with an emphasis on understanding complex concepts through simplified mathematical models. The objective is to provide a solid foundation for readers in systems neuroscience. Key Topics Fundamental Brain Dynamics: Covers the basics of brain organization, neural systems, and the role of differential equations in neuroscience (Chapters 1-3). Spatial Navigation: Discusses the neural mechanisms underlying spatial navigation and the geometry of neural maps (Chapter 4). Alzheimer’s Disease: Presents a simplified mathematical theory of Alzheimer’s dementia, exploring its onset, progression, and potential interventions (Chapter 5). Key Features Accessible Approach: Minimizes mathematical complexity to make the subject approachable for readers with a basic understanding of differential equations. Standalone Resource: Provides all essential knowledge on brain function, making it a valuable tool for both coursework and self-study. Includes references for advanced readers.
Is the everyday understanding of belief susceptible to scientific investigation? Belief is one of the most commonly used, yet unexplained terms in neuroscience. Beliefs can be seen as forms of mental representations and one of the building blocks of our conscious thoughts. This book provides an interdisciplinary overview of what we currently know about the neural basis of human belief systems, and how different belief systems are implemented in the human brain. The chapters in this volume explain how the neural correlates of beliefs mediate a range of explicit and implicit behaviours ranging from moral decision making, to the practice of religion. Drawing inferences from philosophy, psychology, psychiatry, religion, and cognitive neuroscience, the book has important implications for understanding how different belief systems are implemented in the human brain, and outlines the directions which research on the cognitive neuroscience of beliefs should take in the future. The Neural Basis of Human Belief Systems will be of great interest to researchers in the fields of psychology, philosophy, psychiatry, and cognitive neuroscience.
Fully updated and revised according to student feedback, the sixth edition of Mayo Clinic Medical Neurosciences: Organized by Neurologic System and Level provides a systematic approach to anatomy, physiology, and pathology of the nervous system inspired by the neurologist's approach to solving clinical problems. This volume has 4 sections: 1) an overview of the neurosciences necessary for understanding anatomical localization and pathophysiologic characterization of neurologic disorders; 2) an approach to localizing lesions in the 7 longitudinal systems of the nervous system; 3) an approach to localizing lesions in the 4 horizontal levels of the nervous system; and 4) a collection of clinical problems. This book provides the neuroscience framework to support the neurologist in a clinical setting and is also a great resource for neurology and psychiatry board certifications. This is the perfect guide for all medical students and neurology, psychiatry, and physical medicine residents at early stages of training. New to This Edition - A chapter devoted to multiple-choice questions for self-assessment - Discussion of emerging concepts in molecular, cellular, and system neurosciences - New chapters on emotion and consciousness systems - Incorporation of new discoveries in neuroimaging and an appendix for tables of medications commonly used to treat neurologic disorders
This book presents the proceedings of the virtual conference NeuroIS Retreat 2020, June 2–4, hosted in Austria, reporting on topics at the intersection of information systems (IS) research, neurophysiology and the brain sciences. Readers will discover the latest findings from top scholars in the field of NeuroIS, which offer detailed insights on the neurobiology underlying IS behavior, essential methods and tools and their applications for IS, as well as the application of neuroscience and neurophysiological theories to advance IS theory.
A synthesis of current approaches to adapting engineering tools to the study of neurobiological systems.
Closed Loop Neuroscience addresses the technical aspects of closed loop neurophysiology, presenting the implementation of these approaches spanning several domains of neuroscience, from cellular and network neurophysiology, through sensory and motor systems, and then clinical therapeutic devices. Although closed-loop approaches have long been a part of the neuroscientific toolbox, these techniques are only now gaining popularity in research and clinical applications. As there is not yet a comprehensive methods book addressing the topic as a whole, this volume fills that gap, presenting state-of-the-art approaches and the technical advancements that enable their application to different scientific problems in neuroscience. - Presents the first volume to offer researchers a comprehensive overview of the technical realities of employing closed loop techniques in their work - Offers application to in-vitro, in-vivo, and hybrid systems - Contains an emphasis on the actual techniques used rather than on specific results obtained - Includes exhaustive protocols and descriptions of software and hardware, making it easy for readers to implement the proposed methodologies - Encompasses the clinical/neuroprosthetic aspect and how these systems can also be used to contribute to our understanding of basic neurophysiology - Edited work with chapters authored by leaders in the field from around the globe – the broadest, most expert coverage available