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That residues of pesticide and other "foreign" chemicals in food stuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of "Residue Reviews" and by the gratifying enthusiasm, sincerity, and efforts shown by all the in dividuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food-additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being dis placed by newly developed ones more acceptable to food technologists, pharmacologists, taxicologists, and changing pest-control requirements in progressive food-producing economies. These matters are of genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these chemicals per sisting into our foodstuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemical, food technological, medical, pharmacological, and toxicological disciplines.
This book reviews the latest developments concerning the analysis, fate, behaviour and toxicity of pyrethroid insecticides. Over the last few decades, pyrethroid insecticides have increasingly replaced organochlorine pesticides due to their relatively lower mammalian toxicity, selective insecticide activity and lower environmental persistence. They represent 25% of global sales of insecticides, and are considered to be “safe” since they are converted to non-toxic metabolites by oxidative metabolism in fish and by hydrolysis in mammals. However, recent studies have demonstrated their environmental ubiquity, their bioaccumulation and their toxicity in various aquatic and terrestrial organisms, and even in humans. Featuring contributions by leading experts, the book discusses the physico-chemical properties and uses of pyrethroid insecticides; the latest chemical analytical methods; their occurrence in the environment, biota and food; and their isomeric and enantiomeric behaviour. It particularly highlights the toxicological effects and human exposure to pyrethroid insecticides, and also offers insights into the effects of the salmon industry on the marine environment with a case study of sea lice treatment using pyrethroids. This comprehensive book is a valuable source of information for environmental scientists, policymakers and producers interested in issues related to pyrethroid insecticides.
Neurotoxicity of Pesticides, Volume Four, in this comprehensive serial addresses contemporary advances in neurotoxicology of pesticides by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Organophosphates, OPs, Nerve agents, Pyrethroids, Neonicotinoids and Formamidines, among others.
Provides a single-source reference for readers interested in the development of analytical methods for analyzing non-antimicrobial veterinary drug residues in food Provides a comprehensive set of information in the area of consumer food safety and international trade Covers general issues related to analytical quality control and quality assurance, measurement uncertainty, screening and confirmatory methods Details many techniques including nanotechnology and aptamer based assays covering current and potential applications for non-antimicrobial veterinary drugs Provides guidance for analysis of banned drugs including natural and synthetic steroids, Resorcylic acid lactones, and Beta-agonists
Dieser Band gehört zur bekannten Wiley-Reihe 'Current Toxicology Series' und befasst sich ausführlich mit der Pestizidtoxikologie. Untersucht werden Pestizide nach Gruppen (z. B. Insektizide und Fungizide), ihre Rückstände in Lebensmitteln sowie die Metabolisierung von Pestiziden. Darüber hinaus werden berufsbezogene Aspekte und die Behandlung von Vergiftungserscheinungen umfassend diskutiert. "Pesticide Toxicology" ist das erste einbändige Werk zum Thema Pestizide, das spezialisierte und dennoch umfassende Informationen sowohl für Experten als auch für Doktoranden bereit hält. Herausgeber Timothy Marrs ist ein international anerkannter Experte in der Pestizidforschung und genießt großes Ansehen auf dem Gebiet der Toxikologie. Geschrieben wurde der Band von einem Team international renommierterToxikologen.
For over 160 years, pyrethrum has been safely and effectively used as a pesticide the world over. The flowers of this daisy, which contain a mixture of pleasant-smelling esters called the pyrethrins, have highly unusual insecticidal properties. Unique in their ability to repel most insect pests while posing virtually no threat to the environment, pyrethrins have been the subject of great interest to a wide variety of scientists. This book presents for the first time in over twenty years an in-depth look at the many issues surrounding the use of pyrethrins. John E. Casida, a world-renowned authority on the subject, has assembled a group of distinguished contributors to discuss topics ranging from the relationship between pyrethrum and synthetic pyrethroids to cultivation to metabolism to mammalian and environmental toxicology. Along the way, the history of pyrethrum flowers and pyrethrins, the chemistry of active pyrethrin ingredients, the mode of action and resistance, the control of pests, and residues and tolerances are also expertly treated. As safety aspects of pesticides are reevaluated with regard to current regulatory, social, and political implications, pyrethrum has increasingly been seen as the prototype for safe, natural pesticides. Engaging and profusely illustrated, Pyrethrum Flowers is the perfect introduction to the most important natural botanical pesticide. It will appeal to all scientists concerned with pesticides, including botanists, geneticists, biochemists, entomologists, and ecologists.
Xenobiotic compounds including pesticides, nitrophenols, pyridine, polycyclic aromatic compounds and polychlorinated biphenyls are widely spread in environment due to anthropogenic activities. Most of them are highly toxic to living beings due to their mutagenic and carcinogenic properties. Therefore, the removal of these compounds from environment is an essential step for environmental sustainability. Microbial remediation has emerged as an effective technology for degradation of these xenobiotic compounds as microorganisms have unique ability to utilize these compounds as their sole source of carbon and energy. The primary goal of this book is to provide detailed information of microbial degradation of many xenobiotic compounds in various microorganisms.
Gas chromatography mass spectrometry (GC-MS) has been the technique of choice of analytical scientists for many years. The latest developments in instrumentation, including tandem mass spectrometry (MS-MS) and time-of-flight (TOF) detectors, have opened up and broadened the scope of environmental analytical chemistry. This book summarizes the major advances and relevant applications of GC-MS techniques over the last 10 years, with chapters by leading authors in the field of environmental chemistry. The authors are drawn from academia, industry and government. The book is organized in three main parts. Part I covers applications of basic GC-MS to solve environmental-related problems. Part II focuses on GC-MS-MS instrumentation for the analyses of a broad range of analysis in environmental samples (pesticides, persistent organic pollutants, endocrine disruptors, etc.). Part III covers the use of more advanced GC-MS techniques using low- and high-resolution mass spectrometry for many applications related to the environment, food and industry. - Summarizes the major advances of GC-MS techniques in the last decade - Presents relevant applications of GC-MS techniques - Covers academic, industrial and governmental sectors
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.