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Advances in axon biology are so rapid that every year provides us with a wealth of new facts and observations; hence, this conference cannot reasonable be expected to answer all questions. Rather, its purpose must be to take stock of the available data, to communicate advances and new concepts, and to help us to formulate the goals and approaches for future research. To this end, ample time was allotted during the symposium for discussion, but these exchanges of thoughts cannot, unfortunately, be included in the printed text. We hope that publication of the presentations will provide a valuable source of information on the present state of knowledge on this most important borderland between neuro pathology, neurophysiology and neurochemistry. We would like to express our gratitude to all participants of the symposium for contributing their efforts and for their enthusiasm. We are also indebted to Springer Verlag and Bergmann Verlag for publication of the symposium and for their appreciation of the editorial concerns.
First multi-year cumulation covers six years: 1965-70.
Recent physiologic investigations have shown that the deep cerebellar nuclei may play an important role in the initiation and monitoring of skilled move ments. Much of this physiologic work has been carried out in the absence of a secure foundation in neuroanatomical information. Although the main sources of the afferent fibers and the major terminations of the efferent fibers related to these nuclei have been known for many years, remarkably little information about the organization of the nuclei themselves has been collected. The kinds of nerve cells, their arrangement within the nuclei, the patterns of their dendritic arborizations, the distribution of incoming fibers among the neurons, the relationship between the outgoing nerve fibers and the nerve cells from which they originate - these and many other morphologic features were either unknown or only superficially explored. In fact, so little was known about the deep cerebellar nuclei when I began to work on this subject that the investigations reported here are virtually without antecedents, a refreshing change from the cerebellar cortex which has been repeatedly and exhaustively surveyed. My studies on the cerebellar nuclei began in the spring of 1972. They were initiated with the intent of applying the principles of analysis that had been developed for the cerebellar cortex to a different but related part of the brain.
More than 150 years have passed since involvement of the nervous system in leukemia was first reported by BURNS, while the possibility of the primary brain tumor derived from the lymphoreticular tissue was recognized much later. BAILEY in 1929 described such neoplasms under the term perithelial sarcoma. Later these tumors of the nervous system have been variously designated as "Perivascular of perithelial sarcomas, reticulum cell sarcomas or microgliomas", as controversy has evolved and still exists on the definition of this group of neoplasms and on the nature of their cells of origin. Much of the unfortunate confusion concerning the neoplastic lesions attributed to "microglia" and other derivations of the RE system arose because their close relationship to extra neural cells has been ignored. On the other hand, communication in the field of malignant lymphomas has become increasingly difficult because of the termino logic maze and conceptual diversities of traditional morphological classifica tions that have limited valid comparisons. Although at present we are still far from a precise recognition of the basic features of lymphoproliferative processes and from a fairly general agreement on the terminology of non-Hodgkin lymphomas, there is encouraging evidence recently of some enlightment on the nature of tumor cells that provides the basis for a reasonable and generally acceptable lymphoma classification.