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I am very happy and honoured to have so many famous contrib utors from around the world presenting their knowledge and experience in this book, including Dr. Rufer who, as early as 1967, attempted to improve the pressure-volume curve of a child dying from RDS using dried surfactant from dogs; Drs. Enhorn ing and Robertson who were the first to treat rabbit fetuses with surfactant replacement and impressively demonstrated that sur factant improved lung mechanics; and Dr. Fujiwara who at the end of the 1970's had already successfully treated the first babies with surfactant replacement and published this work al ready in 1980. Thus, the idea of surfactant replacement therapy is now more or less 20 years old and almost 10 years have passed since the first publication by Dr. Fujiwara of his impressive clinical results. Up to now (September, 1988) about 2,200 babies have been treated worldwide with tracheal instillation of surfactant, with most promising results. The type of surfactant used varies from pure natural extracts from bovine or pig lungs, to surfactant extracted from human amniotic fluid, to pure phospholipids. To date, however, there is still no surfactant commercially available (except in Japan), in spite of the fact that it is urgently awaited by neonatologists and intensive care doctors throughout the world. This volume is based on the contributions presented at the international congress on Surfactant Replacement Therapy which was held in Rotterdam, The Netherlands, in November 1987.
Innovations and Frontiers in Neonatology provides up-to-date information for clinicians and scientists interested in perinatal medicine. Neonatal transition, neonatal medicine from a global perspective, aspects of care including nutrition, respiratory and temperature management, resuscitation, family-centered approaches, and problems of the term newborn are covered as are complications and long-term consequences of preterm birth. Should we ventilate and how? What are the lifelong consequences of being born too small? How can we protect the neonatal brain? Can we actively influence the microbiome? Can we achieve individualized medicine with the help of metabolomics, for example? Are stem cells the miracle cure? These are just a few of the questions that world experts cover in this book while, at the same time, they take a look at the future of neonatal medicine.
Integrating basic and clinical research on the biophysical and physiological functions of pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on surfactant-related lung disease. Manage neonatal respiratory distress syndrome (RDS), acute respiratory distress syndrome (ARDS), and acute lung injury more effectively!
Written by outstanding authorities from all over the world, this comprehensive new textbook on pediatric and neonatal ventilation puts the focus on the effective delivery of respiratory support to children, infants and newborns. In the early chapters, developmental issues concerning the respiratory system are considered, physiological and mechanical principles are introduced and airway management and conventional and alternative ventilation techniques are discussed. Thereafter, the rational use of mechanical ventilation in various pediatric and neonatal pathologies is explained, with the emphasis on a practical step-by-step approach. Respiratory monitoring and safety issues in ventilated patients are considered in detail, and many other topics of interest to the bedside clinician are covered, including the ethics of withdrawal of respiratory support and educational issues. Throughout, the text is complemented by numerous illustrations and key information is clearly summarized in tables and lists.
One of the key tools in effectively managing critical illness is the use of mechanical ventilator support. This essential text helps you navigate this rapidly evolving technology and understand the latest research and treatment modalities. A deeper understanding of the effects of mechanical ventilation will enable you to optimize patient outcomes while reducing the risk of trauma to the lungs and other organ systems. A physiologically-based approach helps you better understand the impact of mechanical ventilation on cytokine levels, lung physiology, and other organ systems. The latest guidelines and protocols help you minimize trauma to the lungs and reduce patient length of stay. Expert contributors provide the latest knowledge on all aspects of mechanical ventilation, from basic principles and invasive and non-invasive techniques to patient monitoring and controlling costs in the ICU. Comprehensive coverage of advanced biological therapies helps you master cutting-edge techniques involving surfactant therapy, nitric oxide therapy, and cytokine modulators. Detailed discussions of both neonatal and pediatric ventilator support helps you better meet the unique needs of younger patients.
Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.
Dr. Richard Polin's Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient. - Stay fully up to date in this fast-changing field with The Newborn Lung, 3rd Edition. - The most current clinical information throughout, including key management strategies that may reduce some of the chronic sequelae of neonatal respiratory failure. - New content on the role of microbiome in lung injury and lung development. - Current coverage of non-invasive respiratory support, perinatal events and their influence on lung development and injury, cell-based lung therapy, automation of respiratory support, and oxygenation targeting in preterm infants. - Consistent chapter organization to help you find information quickly and easily. - The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume set!Gastroenterology and NutritionHematology, Immunology and GeneticsHemodynamics and CardiologyInfectious Disease and Pharmacology New Volume!Nephrology and Fluid/Electrolyte PhysiologyNeurologyThe Newborn Lung
This book is an outstanding attempt to standardize bedside neonatal respiratory care by the most researched authentic experts in the world. This involves more than sixty authors from the United States, the United Kingdom, Canada, Australia, Spain, Italy, Germany, India, UAE, and China. The latest in the arena of neonatal ventilation which holds future promise has been incorporated in this book. The experts take you through a real-time progression of bedside ventilation practices, with the focus on pulmonary and neurological morbidity. The e-book has links to videos of critical chapters and lecture PPTs to give the intensivist a 360-degree understanding of the complexities of neonatal ventilation. First comprehensive bedside management book of a baby on assisted ventilation. Latest evidence-based practices on noninvasive ventilation with protocols. A bedside guide for neonatologists, fellows, residents, postgraduates, medical students, nurse practitioners, and respiratory therapists. Management of assisted ventilation including high-frequency ventilation and NAVA. Analysis and algorithmic approach to cardiac hemodynamics in respiratory distress. Protocolized approaches to critical respiratory diseases of the newborn. Ancillary services explained in detail like targeted ECHO, NIRS, and Graphics by experts. Videos and lecture presentations by experts on SLI, CPAP, SNIPPV, NAVA, ECHO, and Graphics.
Enhance your knowledge of neonatal-perinatal medicine and/or study for Neonatal-Perinatal Medicine board certification or recertification with this new study guide from the editors of NeoReviews. This new guide includes more than 1,200 questions previously published in NeoReviews from January 2007 to December 2017. Each question is followed by a short explanation of the correct answer with references, including the original article. Chapters include Cardiology Dermatology Endocrinology ENT and Ophthalmology Fluids, Electrolytes, Nutrition Gastrointestinal Genetics and Inborn Errors of Metabolism Hematology/Oncology Immunology Infectious Diseases Maternal-Fetal Medicine Neonatal Resuscitation Neurology Renal Respiratory Statistics, Research, Health Services, and Ethics