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This book endeavours to present an analysis of the current knowledge of the structure properties and possible functions of histones. The broad scope of this topic prevents the discussion of certain individual aspects in any detail. For this purpose, some of the more specialised review articles should be consulted. However, the present volume will contribute to a more general understanding of histone biochemistry and will provide stimulation, as well as source references, to the student of the cell nucleus and its functions.
This book endeavours to present an analysis of the current knowledge of the structure properties and possible functions of histones. The broad scope of this topic prevents the discussion of certain individual aspects in any detail. For this purpose, some of the more specialised review articles should be consulted. However, the present volume will contribute to a more general understanding of histone biochemistry and will provide stimulation, as well as source references, to the student of the cell nucleus and its functions.
Histones are DNA-binding proteins that help in the packaging of DNA to fit into the cell nucleus in a hierarchy of organization. During the packaging and unfolding process, histones are involved in crucial biological activities at the molecular level. This book presents research in the study of histone class, structure and function, including the roles of linker histones in chromatin structure, the post-translational modifications of histones and the importance of chromatin structure and epigenetics in gene regulation and carcinogenesis. (Imprint: Nova)
This comprehensive book is a compilation of Professor Lubomir S. Hnilica's twenty years of research experimentally addressing the chemistry and the biological functions of chromosomal proteins. The histones and other nuclear proteins found associated with DNA in a number of tissues and cell types are featured. Lubomir Hnilica played a major role in establishing the extent to which these basic chromosomal polypeptides are conserved and the manner in which they interact with DNA to modify chromatin structure. In addition, non-histone chromosomal protein research is explained, and his technique of applying several biochemical and immunological approaches to the characterization of this complex and heterogeneous class of chromosomal polypeptides is discussed. Highlighted is the use of chemical crosslinking for studying protein/DNA interactions in intact cells. The proteins as well as the structure, organization, and regulation of the genes are also presented.
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
The histones are now a very well established part of Biochemistry. The interpretation of all that is known about them, however, is already too great a burden for a single author to undertake. Indeed, a survey of the indexed literature shows that the number of publications on the histones has approximately doubled in every three years for the past 15 years, and is now several hundred a year. It is time then to bring together in one publication the major topics embraced by this great research effort. This book therefore endeavours to give, in six chapters, a broad and searching account of the biochemistry and biophysics of these interesting proteins and their complexes with nucleic acids, the nucleohistones. Each chapter is written by different authors who are all active in this research and who have had many years experience with these proteins and their complexes. Chapters 1, 2, part of 3, and all of Chapters 5 and 6, cover the occurrence, preparation, characterization, sequence structure, bio physical properties and finally, the biosynthesis and functions of the histones. The other part of Chapter 3, the whole of Chapter 4 and to a less extent some other chapters, all discuss the properties and structure of the nucleohistones. The study of these complexes is undoubtedly of great importance in bridging the gaps in our knowledge of template activity and differentiation as well as of chromosomal structure and mechanics.
The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization, DNA methylation, and transcriptional co-activators and co-repressors. The book is written in a clear and concise fashion, with 60 new illustrations. Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and its active involvement in the processes of DNA transcription, replication and repair. This book consistently interrelates the structure of eukaryotic DNA with the nuclear processes it undergoes, and will be essential reading for students and molecular biologists who want to really understand how DNA works. Written in a clear and concise fashion Includes 60 new illustrations Extensively rewritten Brings the reader up-to-date with the remarkable progress in chromatin research over the past three years.
The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.