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Winner of the 2023 PROSE Award for Excellence in Biological and Life Sciences and the 2023 Chautauqua Prize! Named a New York Times Notable Book and a Best Book of the Year by The Economist, Oprah Daily, BookPage, Book Riot, the New York Public Library, and more! In The Song of the Cell, the extraordinary author of the Pulitzer Prize–winning The Emperor of All Maladies and the #1 New York Times bestseller The Gene “blends cutting-edge research, impeccable scholarship, intrepid reporting, and gorgeous prose into an encyclopedic study that reads like a literary page-turner” (Oprah Daily). Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down their handmade microscopes. What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christened them “cells.” The discovery of cells—and the reframing of the human body as a cellular ecosystem—announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer’s dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia—all could be reconceived as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies. Filled with writing so vivid, lucid, and suspenseful that complex science becomes thrilling, The Song of the Cell tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. Told in six parts, and laced with Mukherjee’s own experience as a researcher, a doctor, and a prolific reader, The Song of the Cell is both panoramic and intimate—a masterpiece on what it means to be human. “In an account both lyrical and capacious, Mukherjee takes us through an evolution of human understanding: from the seventeenth-century discovery that humans are made up of cells to our cutting-edge technologies for manipulating and deploying cells for therapeutic purposes” (The New Yorker).
Buy now to get the main key ideas from Siddhartha Mukherjee's The Song of the Cell Medical technologies such as blood transfusions, vaccinations, and genetic modification have saved countless lives. These technologies are all forms of cellular therapy, which involves the manipulation of cells, the most fundamental units of life. In The Song of the Cell (2022), physician Siddhartha Mukherjee provides an overview of the history and science behind cellular biology. He explores how cells work and creates a vision for a future where diseases such as cancer, diabetes, and sickle cell anemia can be permanently cured.
Elegant, suggestive, and clarifying, Lewis Thomas's profoundly humane vision explores the world around us and examines the complex interdependence of all things. Extending beyond the usual limitations of biological science and into a vast and wondrous world of hidden relationships, this provocative book explores in personal, poetic essays to topics such as computers, germs, language, music, death, insects, and medicine. Lewis Thomas writes, "Once you have become permanently startled, as I am, by the realization that we are a social species, you tend to keep an eye out for the pieces of evidence that this is, by and large, good for us."
What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life.
This volume constitutes the refereed proceedings of the 6th International Workshop on Adaptive Multimedia Retrieval, AMR 2008, held in Berlin, Germany, in June 2008.
The legendary critic and author of Mystery Train “ingeniously retells the tale of rock and roll” (Publishers Weekly, starred review). Unlike previous versions of rock ’n’ roll history, this book omits almost every iconic performer and ignores the storied events and turning points everyone knows. Instead, in a daring stroke, Greil Marcus selects ten songs and dramatizes how each embodies rock ’n’ roll as a thing in itself, in the story it tells, inhabits, and acts out—a new language, something new under the sun. “Transmission” by Joy Division. “All I Could Do Was Cry” by Etta James and then Beyoncé. “To Know Him Is to Love Him,” first by the Teddy Bears and almost half a century later by Amy Winehouse. In Marcus’s hands these and other songs tell the story of the music, which is, at bottom, the story of the desire for freedom in all its unruly and liberating glory. Slipping the constraints of chronology, Marcus braids together past and present, holding up to the light the ways that these striking songs fall through time and circumstance, gaining momentum and meaning, astonishing us by upending our presumptions and prejudices. This book, by a founder of contemporary rock criticism—and its most gifted and incisive practitioner—is destined to become an enduring classic. “One of the epic figures in rock writing.”—The New York Times Book Review “Marcus is our greatest cultural critic, not only because of what he says but also, as with rock-and-roll itself, how he says it.”—The Washington Post Winner of the Deems Taylor Virgil Thomson Award in Music Criticism, given by the American Society of Composers, Authors & Publishers
A girl searches for a killer on an island where deadly sirens lurk just beneath the waves in this “twisty, atmospheric story that grips readers like a siren song” (Publishers Weekly, starred review). The sea holds many secrets. Moira Alexander has always been fascinated by the deadly sirens who lurk along the shores of her island town. Even though their haunting songs can lure anyone to a swift and watery grave, she gets as close to them as she can, playing her violin on the edge of the enchanted sea. When a young boy is found dead on the beach, the islanders assume that he’s one of the sirens’ victims. Moira isn’t so sure. Certain that someone has framed the boy’s death as a siren attack, Moira convinces her childhood friend, the lighthouse keeper Jude Osric, to help her find the real killer, rekindling their friendship in the process. With townspeople itching to hunt the sirens down, and their own secrets threatening to unravel their fragile new alliance, Moira and Jude must race against time to stop the killer before it’s too late—for humans and sirens alike.
The Book of Eador, Abjurations 12:14, is very clear: Suffer ye not the life of a witch. For a thousand years, the Church Knights have obeyed that commandment, sending to the stake anyone who can hear the songs of the earth. There are no exceptions, not even for one of their own. Novice Knight Gair can hear music no one else can, beautiful, terrible music: music with power. In the Holy City, that can mean only one thing: death by fire—until an unlikely intervention gives him a chance to flee the city and escape the flames. With the Church Knights and their witchfinder hot on his heels, Gair hasn't time to learn how to use the power growing inside him, but if he doesn't master it, that power will tear him apart. His only hope is the secretive Guardians of the Veil, though centuries of persecution have almost destroyed their Order, and the few Guardians left have troubles of their own. For the Veil between worlds is weakening, and behind it, the Hidden Kingdom, ever-hungry for dominion over the daylight realm, is stirring. Though he is far from ready, Gair will find himself fighting for his own life, for everyone within the Order of the Veil, and for the woman he has come to love. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
"The Gurindji people of the Northern Territory are perhaps best-known for their walk-off of Wave Hill Station in 1966, protesting against mistreatment by the station managers. The strike would become the first major victory of the Indigenous land rights movement. Many discussions of station life are focused on the harsh treatment of Aboriginal workers. Songs from the Stations portrays another side of life on Wave Hill Station. Amongst the harsh conditions and decades of mistreatment, an eclectic ceremonial life flourished during the first half of the 20th century. Constant travel between cattle stations by Indigenous workers across north-western and central Australia meant that Wave Hill Station became a cross-road of desert and Top End musical styles. As a result, the Gurindji people learnt songs from the Mudburra who came further east, the Bilinarra from the north, the Nyininy from the west, and the Warlpiri from the south. This book is the first detailed documentation of wajarra, public songs performed by the Gurindji people in response to contemporary events in their community. Featuring five song sets known as Laka, Mintiwarra, Kamul, Juntara, and Freedom Day, it is an exploration of the cultural exchange between Indigenous communities that was fostered by their involvement in the pastoral industry.."--Publisher's website.
Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.