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This volume provides methods on the study of the systems of the brain. Chapters are divided into four parts covering; discriminative touch, proprioception and kinaesthesis, affective touch, individual differences due to atypical development, ageing, illusions and sensory substitution, microneurography, electrophysiology, brain imaging, and brain stimulation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation. Thorough and comprehensive, Somatosensory Research Methods aims to be comprehensive guide for researchers.
Although somatosensory system works in tandem with the motor system in biology, the majority of the prosthetics research and commercial efforts had focused on accommodating movement deficits. With the development of neuroprostheses in the last 15 years, it has become evident that somatosensory input (mainly as touch and proprioception) is essential for motor control, manipulating objects, and embodiment, in addition to its primary role for sensory perception. Somatosensory Feedback for Neuroprosthetics covers all relevant aspects to facilitate learning and doing research and development in the field. To understand the properties of the body to create viable solutions, this book starts with chapters reviewing the basic anatomy, physiology, and psychophysics of the somatosensory system, sensorimotor control, and instrumentation. Some sections are dedicated to invasive (peripheral and central, mainly cortical) and noninvasive (vibrotactile, electrotactile, etc.) approaches. Final chapters cover future technologies such as novel sensors and electrodes, safety, and clinical testing, and help to make up future prospects for this field with an emphasis on development and end use. With contributions from renowned experts, the contents include their recent findings and technical details necessary to understand those findings. Provides a concise review of the somatosensory system and latest advances in the use of somatosensory feedback for neuroprosthetics Analyzes many approaches to somatosensory feedback Provides the most detailed work on somatosensory neuroprostheses, their development, and applications in real life work
Extensively updated and expanded, this second edition of a bestseller distills the current state-of-the-science and provides the nuts and bolts foundation of the methods involved in this rapidly growing science. With contributions from pioneering researchers, it includes microwire array design for chronic neural recordings, new surgical techniques for chronic implantation, microelectrode microstimulation of brain tissue, multielectrode recordings in the somatosensory system and during learning, as well as recordings from the central gustatory-reward pathways. It explores the use of Brain-Machine Interface to restore neurological function and proposes conceptual and technical approaches to human neural ensemble recordings in the future.
Agency has two meanings in psychology and neuroscience. It can refer to one's capacity to affect the world and act in line with one's goals and desires--this is the objective aspect of agency. But agency can also refer to the subjective experience of controlling one's actions, or how it feels to achieve one's goals or affect the world. This subjective aspect is known as the sense of agency, and it is an important part of what makes us human. Interest in the sense of agency has exploded since the early 2000s, largely because scientists have learned that it can be studied objectively through analyses of human judgment, behavior, and the brain. This book brings together some of the world's leading researchers to give structure to this nascent but rapidly growing field. The contributors address questions such as: What role does agency play in the sense of self? Is agency based on predicting outcomes of actions? And what are the links between agency and motivation? Recent work on the sense of agency has been markedly interdisciplinary. The chapters collected here combine ideas and methods from fields as diverse as engineering, psychology, neurology, neuroscience, and philosophy of mind, making the book a valuable resource for any student or researcher interested in action, volition, and exploring how mind and brain are organized.
Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. - Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods - Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more - Clear, straightforward explanations of each technique for anyone new to the field - A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture - Detailed recommendations on where to find protocols and other resources for specific techniques - "Walk-through" boxes that guide readers through experiments step-by-step
Exploring new and past research in the understanding of how the brain deals with its own body image, this book provides a review of pertinent literature and offers comprehensive descriptions of technical approaches. The material includes new frameworks for the conceptualization of the system's representations, scientific and clinical applications that stem from these approaches based on the new concepts, and a discussion of tools used to study the interface of the brain and the body. The book provides computational strategies for sensorimotor integration of the mammalian brain and includes algorithms for the design and implementation of haptic interfaces and tactile displacement.
This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements.
Methods in Chemosensory Research describes new molecular, electrophysiological, engineering, genetic, behavioral, psychophysical, and imaging techniques that have recently been adapted to investigate the basic neuronal mechanisms underlying chemoreception. Written by leaders in the field of neuronal chemoreception specializing in olfaction, gustation, baroreception, and chemical irritation caused by environmental pollutants, this unique book combines novel methods to investigate all aspects of taste and olfaction. These methods range from the molecular level to the investigation of individual cell taste and olfactory epithelia.
This book is a practical guide to the evidence-based medicine (EBM) research methods that are applicable to Chinese medicine (CM). It includes 3 parts: clinical research, healthcare data research and laboratory research. In each chapter, it explains how to acquire, analyze and evaluate a specific kind of CM research result. Authors exemplify the most important methods with successful cases in transforming reliable data into new knowledge of CM. This book emphasizes the requirements for CM researchers to design and conduct CM studies by following the best available principles, standards and guidelines.