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This work focuses on the simulated performance of a high-resolution, depth-of-interaction (DOI) capable PET detector module with a single-ended readout. I propose the use of a monolithic scintillator up to several centimetres thick directly coupled to a 2D array of Silicon Photomultipliers. High resolution of reconstructed energy and 3D position of gamma rays interacting with the detector is achieved through the implementation of Maximum Likelihood Estimation (MLE) of said parameters. A notable difference in the implementation of MLE described herein is the direct estimation of the interacting gamma-ray energy. Additionally, a performance evaluation of two prominent event windowing techniques used in PET -- energy windowing and likelihood windowing -- is presented. The proposed design and reconstruction algorithms have been validated using Geant4-based Monte Carlo simulations. Two different versions of the detector module -- one with an absorptive coating and the other with a reflective coating - were simulated, and a comparison of reconstruction performance is presented. It is found that the module with the reflective wrapping significantly out-performs the module with the absorptive wrapping in terms of the resolution of the reconstructed 3D position and energy of incoming gamma rays due to the increased amount of scintillation light detected with the reflective configuration. The reflective configuration simulated herein achieves an average 3D position resolution of ~ 1 mm, and an average energy resolution of ~ 11 %. Based on an analysis of the simulated detector module performance versus scintillator thickness presented in this thesis, a scintillator thickness of 1.5 cm was chosen for future prototypes in order to strike a balance between position and energy resolution performance and detection efficiency. A small bore PET system employing this configuration of module will have volumetric resolution of reconstructed images in the sub-millimeter range, energy resolution of ~ 11 % and sensitivity of ~ 28 %.
In this issue of PET Clinics, guest editors Arman Rahmim, Babak Saboury, and Eliot Siegel bring their considerable expertise to the topic of Artificial Intelligence and PET Imaging. Provides in-depth, clinical reviews on the latest updates in AI and PET Imaging, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.
In this work, the authors provide up-to-date, comprehensive information on the physics underlying modern nuclear medicine and imaging using radioactively labelled tracers. Examples are presented with solutions worked out in step-by-step detail, illustrating important concepts and calculations.
This book is designed to give the reader a solid understanding of the physics and instrumentation aspects of PET, including how PET data are collected and formed into an image. Topics include basic physics, detector technology used in modern PET scanners, data acquisition, and 3D reconstruction. A variety of modern PET imaging systems are also discussed, including those designed for clinical services and research, as well as small-animal imaging. Methods for evaluating the performance of these systems are also outlined. The book will interest nuclear medicine students, nuclear medicine physicians, and technologists.
Winner of the 2006 Joseph W. Goodman Book Writing Award! A comprehensive treatment of the principles, mathematics, and statistics of image science In today's visually oriented society, images play an important role in conveying messages. From seismic imaging to satellite images to medical images, our modern society would be lost without images to enhance our understanding of our health, our culture, and our world. Foundations of Image Science presents a comprehensive treatment of the principles, mathematics, and statistics needed to understand and evaluate imaging systems. The book is the first to provide a thorough treatment of the continuous-to-discrete, or CD, model of digital imaging. Foundations of Image Science emphasizes the need for meaningful, objective assessment of image quality and presents the necessary tools for this purpose. Approaching the subject within a well-defined theoretical and physical context, this landmark text presents the mathematical underpinnings of image science at a level that is accessible to graduate students and practitioners working with imaging systems, as well as well-motivated undergraduate students. Destined to become a standard text in the field, Foundations of Image Science covers: Mathematical Foundations: Examines the essential mathematical foundations of image science Image Formation–Models and Mechanisms: Presents a comprehensive and unified treatment of the mathematical and statistical principles of imaging, with an emphasis on digital imaging systems and the use of SVD methods Image Quality: Provides a systematic exposition of the methodology for objective or task-based assessment of image quality Applications: Presents detailed case studies of specific direct and indirect imaging systems and provides examples of how to apply the various mathematical tools covered in the book Appendices: Covers the prerequisite material necessary for understanding the material in the main text, including matrix algebra, complex variables, and the basics of probability theory
The scope of the conference is to present advancements in the field of nuclear science (detectors, electronics and algorithms) as applied to high energy and nuclear physics, as well as various imaging techniques used in Medicine The conference fosters interactions between instrumentation research and end user application expertise, thus highlighting interdisciplinary aspects of nuclear science
This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
This book describes the fundamentals of particle detectors as well as their applications. Detector development is an important part of nuclear, particle and astroparticle physics, and through its applications in radiation imaging, it paves the way for advancements in the biomedical and materials sciences. Knowledge in detector physics is one of the required skills of an experimental physicist in these fields. The breadth of knowledge required for detector development comprises many areas of physics and technology, starting from interactions of particles with matter, gas- and solid-state physics, over charge transport and signal development, to elements of microelectronics. The book's aim is to describe the fundamentals of detectors and their different variants and implementations as clearly as possible and as deeply as needed for a thorough understanding. While this comprehensive opus contains all the materials taught in experimental particle physics lectures or modules addressing detector physics at the Master's level, it also goes well beyond these basic requirements. This is an essential text for students who want to deepen their knowledge in this field. It is also a highly useful guide for lecturers and scientists looking for a starting point for detector development work.