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A scientific and educational journal not only for professional statisticians but also for economists, business executives, research directors, government officials, university professors, and others who are seriously interested in the application of statistical methods to practical problems, in the development of more useful methods, and in the improvement of basic statistical data.
This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.
A comprehensive overview of environmetric research and its applications... Environmetrics covers the development and application of quantitative methods in the environmental sciences. It provides essential tools for understanding, predicting, and controlling the impacts of agents, both man-made and natural, which affect the environment. Basic and applied research in this area covers a broad range of topics. Primary among these are the quantitative sciences, such as statistics, probability and applied mathematics, chemometrics, and econometrics. Applications are also important, for example in, ecology and environmental biology, public health, atmospheric science, geology, engineering, risk management, and regulatory/governmental policy amongst others. * Divided into 12 sections, the Encyclopedia brings together over 600 detailed articles which have been carefully selected and reviewed through the collaborative efforts of the Editors-in-Chief and the appropriate Section Editor * Presented in alphabetical order all the articles will include an explanatory introduction, extensive cross-referencing and an up-to-date bibliography providing literature references for further reading. Presenting state of the art information in a readable, highly accessible style, the scope and coverage provided by the Encyclopedia of Environmetrics will ensure its place as the landmark reference for the many scientists, educators, and decision-makers working across this multidisciplinary field. An essential reference tool for university libraries, research laboratories, government institutions and consultancies concerned with the environmental sciences, the Encyclopedia of Environmetrics brings together for the first time, comprehensive coverage of the full range of topics, techniques and applications covered by this multidisciplinary field. There is currently no central reference source which addresses the needs of this multidisciplinary community. This new Encyclopedia will fill this gap by providing a comprehensive source of relevant fundamental concepts in environmetric research, development and applications for statisticians, mathematicians, economists, environmentalists, ecologist, government officials and policy makers.
The Statistical Analysis of Multivariate Failure Time Data: A Marginal Modeling Approach provides an innovative look at methods for the analysis of correlated failure times. The focus is on the use of marginal single and marginal double failure hazard rate estimators for the extraction of regression information. For example, in a context of randomized trial or cohort studies, the results go beyond that obtained by analyzing each failure time outcome in a univariate fashion. The book is addressed to researchers, practitioners, and graduate students, and can be used as a reference or as a graduate course text. Much of the literature on the analysis of censored correlated failure time data uses frailty or copula models to allow for residual dependencies among failure times, given covariates. In contrast, this book provides a detailed account of recently developed methods for the simultaneous estimation of marginal single and dual outcome hazard rate regression parameters, with emphasis on multiplicative (Cox) models. Illustrations are provided of the utility of these methods using Women’s Health Initiative randomized controlled trial data of menopausal hormones and of a low-fat dietary pattern intervention. As byproducts, these methods provide flexible semiparametric estimators of pairwise bivariate survivor functions at specified covariate histories, as well as semiparametric estimators of cross ratio and concordance functions given covariates. The presentation also describes how these innovative methods may extend to handle issues of dependent censorship, missing and mismeasured covariates, and joint modeling of failure times and covariates, setting the stage for additional theoretical and applied developments. This book extends and continues the style of the classic Statistical Analysis of Failure Time Data by Kalbfleisch and Prentice. Ross L. Prentice is Professor of Biostatistics at the Fred Hutchinson Cancer Research Center and University of Washington in Seattle, Washington. He is the recipient of COPSS Presidents and Fisher awards, the AACR Epidemiology/Prevention and Team Science awards, and is a member of the National Academy of Medicine. Shanshan Zhao is a Principal Investigator at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina.
Although standard mixed effects models are useful in a range of studies, other approaches must often be used in correlation with them when studying complex or incomplete data. Mixed Effects Models for Complex Data discusses commonly used mixed effects models and presents appropriate approaches to address dropouts, missing data, measurement errors, censoring, and outliers. For each class of mixed effects model, the author reviews the corresponding class of regression model for cross-sectional data. An overview of general models and methods, along with motivating examples After presenting real data examples and outlining general approaches to the analysis of longitudinal/clustered data and incomplete data, the book introduces linear mixed effects (LME) models, generalized linear mixed models (GLMMs), nonlinear mixed effects (NLME) models, and semiparametric and nonparametric mixed effects models. It also includes general approaches for the analysis of complex data with missing values, measurement errors, censoring, and outliers. Self-contained coverage of specific topics Subsequent chapters delve more deeply into missing data problems, covariate measurement errors, and censored responses in mixed effects models. Focusing on incomplete data, the book also covers survival and frailty models, joint models of survival and longitudinal data, robust methods for mixed effects models, marginal generalized estimating equation (GEE) models for longitudinal or clustered data, and Bayesian methods for mixed effects models. Background material In the appendix, the author provides background information, such as likelihood theory, the Gibbs sampler, rejection and importance sampling methods, numerical integration methods, optimization methods, bootstrap, and matrix algebra. Failure to properly address missing data, measurement errors, and other issues in statistical analyses can lead to severely biased or misleading results. This book explores the biases that arise when naïve methods are used and shows which approaches should be used to achieve accurate results in longitudinal data analysis.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
The three parts of this book on survey methodology combine an introduction to basic sampling theory, engaging presentation of topics that reflect current research trends, and informed discussion of the problems commonly encountered in survey practice. These related aspects of survey methodology rarely appear together under a single connected roof, making this book a unique combination of materials for teaching, research and practice in survey sampling. Basic knowledge of probability theory and statistical inference is assumed, but no prior exposure to survey sampling is required. The first part focuses on the design-based approach to finite population sampling. It contains a rigorous coverage of basic sampling designs, related estimation theory, model-based prediction approach, and model-assisted estimation methods. The second part stems from original research conducted by the authors as well as important methodological advances in the field during the past three decades. Topics include calibration weighting methods, regression analysis and survey weighted estimating equation (EE) theory, longitudinal surveys and generalized estimating equations (GEE) analysis, variance estimation and resampling techniques, empirical likelihood methods for complex surveys, handling missing data and non-response, and Bayesian inference for survey data. The third part provides guidance and tools on practical aspects of large-scale surveys, such as training and quality control, frame construction, choices of survey designs, strategies for reducing non-response, and weight calculation. These procedures are illustrated through real-world surveys. Several specialized topics are also discussed in detail, including household surveys, telephone and web surveys, natural resource inventory surveys, adaptive and network surveys, dual-frame and multiple frame surveys, and analysis of non-probability survey samples. This book is a self-contained introduction to survey sampling that provides a strong theoretical base with coverage of current research trends and pragmatic guidance and tools for conducting surveys.