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Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Triceratops has an itch. . . so does Pterodactyl. . . and Brontosaurus. . . and T-Rex! But DINOSAURS DO NOT SCRATCH. There is a rule written in stone. What is an itchy dinosaur to do?!
Everybody gets itchy, and every kid will love this title that scratches the itch to know more and about the history, anatomy, botany, biology behind it. Perfect for fans of Grossology books looking for something more substantive and dynamic. You can feel it coming on—that terrible, tortuous ITCH. As irritating as an itch is, it is also your body’s way of sending you a message you can’t miss, like you’ve brushed up against poison ivy or lice have taken up residence in your hair. None of which you’d know without that telltale itch! And there are so many things that make us itch—from fungus to fleas, mosquitoes to nettles, poison ivy to tarantulas! Combining history, anatomy, laugh-out-loud illustrations, and even tips to avoid—and soothe—the itch, Anita Sanchez and Gilbert Ford take readers on an intriguing (and sometimes disgusting) look into what makes you scratch.
Find relief from chronic itch in this comprehensive guide. We have all experienced itch, whether from insect bites or dry skin, but millions of people worldwide have chronic or even intractable itch. Just like chronic pain, chronic itch interferes with a person’s ability to function—and even affects quality of life. Living with Itch offers relief, drawing on the authors’ vast knowledge of itch, the suffering it causes, and available treatments. Itch researchers and clinicians Drs. Gil Yosipovitch and Shawn G. Kwatra explain the cascade of physiological events that causes us to experience itch. They describe the many skin diseases, from atopic dermatitis (eczema) to psoriasis, and conditions like chronic kidney disease, lymphoma, HIV, and neuropathies that cause itch. Living with Itch provides information on preventing itch as well as topical and systemic ways to treat it. Patient and parent narratives illustrate how people cope with itch and how, with medical and social support, itch can be managed.
In 7 Keys to Spiritual Wellness, best-selling author Joe Paprocki provides a prescription for spiritual health based on the rich wisdom of Catholic Tradition. Through his nondogmatic, downright inviting style of writing, Paprocki makes this book eminently accessible to non-Catholics and "seekers" as well. Recognizing that the spiritual immune system is weakened almost daily by toxic patterns and attitudes that negatively impact our ability to live in a harmonious relationship with God and others, Paprocki offers seven enduring and reliable strategies for achieving spiritual wellness. After identifying practical ways to integrate each of these strategies into daily living, he describes seven persistent dangers to our spiritual well-being and how these dangers manifest themselves in our lives. At its core, 7 Keys to Spiritual Wellness helps us see the Christian faith not as a collection of rules and doctrine, but as a spiritual path--a path whose guideposts for spiritual wellness are sure to lead us to a more meaningful life and to a much richer experience of our faith.
Open source provides the competitive advantage in the Internet Age. According to the August Forrester Report, 56 percent of IT managers interviewed at Global 2,500 companies are already using some type of open source software in their infrastructure and another 6 percent will install it in the next two years. This revolutionary model for collaborative software development is being embraced and studied by many of the biggest players in the high-tech industry, from Sun Microsystems to IBM to Intel.The Cathedral & the Bazaar is a must for anyone who cares about the future of the computer industry or the dynamics of the information economy. Already, billions of dollars have been made and lost based on the ideas in this book. Its conclusions will be studied, debated, and implemented for years to come. According to Bob Young, "This is Eric Raymond's great contribution to the success of the open source revolution, to the adoption of Linux-based operating systems, and to the success of open source users and the companies that supply them."The interest in open source software development has grown enormously in the past year. This revised and expanded paperback edition includes new material on open source developments in 1999 and 2000. Raymond's clear and effective writing style accurately describing the benefits of open source software has been key to its success. With major vendors creating acceptance for open source within companies, independent vendors will become the open source story in 2001.
Gus the groundhog desperately needs to scratch his back after a mouse tickles him with a feather, but the stick, bush, and log he tries to scratch against are not what they appear to be.
'This book is a not-so-small joy in itself.' NIGELLA LAWSON 'Parkinson has the gift of making you look with new eyes at everyday things. The perfect daily diversion.' JOJO MOYES 'Always funny and frank and full of insight, I absolutely love Parkinson's writing.' DAVID NICHOLLS 'I loved this book . . . Parkinson's writing transports you to unexpected places of joy and comfort . . . these pages contain happiness.' MARINA HYDE 'The twenty-first century feels a lot more bearable in Parkinson's company.' CHARLOTTE MENDELSON Drawn from the successful Guardian column, these everyday exultations and inspirations will get you through dismal days. Hannah Jane Parkinson is a specialist in savouring the small pleasures of life. She revels in her fluffy dressing gown ('like bathing in marshmallow'), finds calm in solo cinema trips, is charmed by the personalities of fonts ('you'll never see Comic Sans on a funeral notice'), celebrates pockets and gleefully abandons a book she isn't enjoying. Parkinson's everyday exaltations - selected from her immensely successful Guardian column - will utterly delight. FEATURES BRAND NEW MATERIAL 'A compendium of delights.' OBSERVER 'Delightful . . . a love letter to those little moments of bliss that get us through the daily grind.' RED
Now in a fully revised thirteenth edition, Andrews' Diseases of the Skin remains your single-volume, must-have resource for core information in dermatology. From residency through clinical practice, this award-winning title ensures that you stay up to date with new tools and strategies for diagnosis and treatment, new entities and newly recognized diseases, and current uses for tried-and-true and newer medications. It's the reference you'll turn to again and again when faced with a clinical conundrum or therapeutically challenging skin disease. - Utilizes a concise, clinically focused, user-friendly format that clearly covers the full range of common and rare skin diseases. - Provides outstanding visual support with 1,340 illustrations – more than 500 new to this edition. - Presents comprehensively updated information throughout, including new and unusual clinical presentations of syphilis, new diagnostic classifications and therapies for vascular anomalies, and an updated pediatric and genodermatosis review. - Covers new and evolving treatments for inflammatory, neoplastic, and blistering skin diseases among others. New biologics and phosphodiesterase inhibitors for psoriasis and atopic dermatitis, JAK inhibitors for alopecia areata and vitiligo, immune checkpoint inhibitors for melanoma and rituximab for pemphigus are all covered. - Features a revised and revamped cutaneous adverse drug reaction section, including novel eruptions from new and emerging chemotherapeutic agents and small molecule/targeted inhibitors. - Discusses new and emerging viruses including Zika and human polyomaviruses.
Providing an alphabetical listing of sexual language and locution in 16th and 17th-century English, this book draws especially on the more immediate literary modes: the theatre, broadside ballads, newsbooks and pamphlets. The aim is to assist the reader of Shakespearean and Stuart literature to identify metaphors and elucidate meanings; and more broadly, to chart, through illustrative quotation, shifting and recurrent linguistic patterns. Linguistic habit is closely bound up with the ideas and assumptions of a period, and the figurative language of sexuality across this period is highly illuminating of socio-cultural change as well as linguistic development. Thus the entries offer as much to those concerned with social history and the history of ideas as to the reader of Shakespeare or Dryden.