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This book provides a comprehensive overview of physiological, biochemical, and genetic pathways underlying drug addiction, and resultant efforts to develop novel treatment strategies dealing with drug addiction and other CNS disorders where the neurophysiological processes overlap, such as treatment of pain. The volume focuses on the translation of fundamental addiction research to a variety of treatments and brings together scientists with wide ranging expertise.
The first comprehensive guide to oneirogens--naturally occurring substances that induce and enhance dreaming • Includes extensive monographs on dream-enhancing substances derived from plant, animal, and human sources • Presents the results of scientific experiments on the effects of using oneirogens • Shows how studies in this area of ethnobotany can yield a scientific understanding of the mysterious mechanism of dreams Oneirogens are plant and animal substances that have long been used to facilitate powerful and productive dreaming. From the beginning of civilization, dreams have guided the inner and outer life of human beings both in relation to each other and to the divine. For centuries shamans have employed oneirogens in finding meaning and healing in their dreams. Drugs of the Dreaming details the properties and actions of these dream allies, establishing ethnobotanical profiles for 35 oneirogens, including those extracted from organic sources--such as Calea zacatechichi (dream herb or “leaf of the god”), Salvia divinorum, and a variety of plants from North and South America and the Pacific used in shamanic practices--as well as synthetically derived oneirogens. They explain the historical use of each oneirogen, its method of action, and what light it sheds on the scientific mechanism of dreaming. They conclude that oneirogens enhance the comprehensibility and facility of the dream/dreamer relationship and hold a powerful key for discerning the psychological needs and destinies of dreamers in the modern world.
The first practical guide to the transformative uses of salvia • Explains how salvia connects you with your higher purpose and aids you in envisioning your unique path in life • Describes appropriate methods of use, a shamanic diet to increase effectiveness, and the meaning of the symbols experienced during salvia’s ecstatic embrace • Explores recent clinical research into salvia’s long-term positive psychological effects and its potential as a treatment for Alzheimer’s, depression, and addiction Salvia divinorum has been used since ancient times by the Mazatec shamans of Mexico for divination, vision quests, and healing. Known by many names--nearly all associated with the Virgin Mary, who has come to symbolize the spirit of salvia--this plant ally is now regarded as the most powerful natural hallucinogen. Providing the first practical guide to the shamanic, spiritual, and therapeutic uses of salvia, Ross Heaven shares his in-depth quest to connect with the spirit of this plant teacher. He explores recent clinical research into its many long-term psychological effects, such as increased insight and self-confidence, improved mood and concentration, and feelings of calmness and connection with nature, as well as salvia’s potential for combating diseases like Alzheimer’s, depression, and even cocaine addiction. Reviewing the traditional Mazatec ceremonies surrounding salvia’s harvest and use, Heaven describes appropriate methods of consumption, typical dosages, and the shamanic diet he used to increase salvia’s effectiveness. Examining firsthand accounts of salvia journeys from around the world, he decodes the meaning of the symbolic images experienced during salvia’s ecstatic embrace and details the interplay between salvia and the lucid dreaming state. Comparing salvia to ayahuasca and the San Pedro cactus, Heaven explains that salvia’s greatest strength as a shamanic plant ally lies in its ability to connect you with your higher purpose and aid you in envisioning your unique path in life.
The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.
This book provides a broad reference covering important drugs of abuse including amphetamines, opiates, and steroids. It also covers psychoactive plants such as caffeine, peyote, and psilocybin. It provides chemical structures, analytical methods, clinical features, and treatments of these drugs of abuse, serving as a highly useful, in-depth supplement to a general medical toxicology book. The style allows for the easy application of the contents to searchable databases and other electronic products, making this an essential resource for practitioners in medical toxicology, industrial hygiene, occupational medicine, pharmaceuticals, environmental organizations, pathology, and related fields.
This handbook reviews promising applications of psychedelics in treatment of such challenging psychiatric problems as posttraumatic stress disorder, major depression, substance use disorders, and end-of-life anxiety. Experts from multiple disciplines synthesize current knowledge on psilocybin, MDMA, ketamine, and other medical hallucinogens. The volume comprehensively examines these substances' neurobiological mechanisms, clinical effects, therapeutic potential, risks, and anthropological and historical contexts. Coverage ranges from basic science to practical clinical considerations, including patient screening and selection, dosages and routes of administration, how psychedelic-assisted sessions are structured and conducted, and management of adverse reactions.
Learn everything you need to know about psychedelics with this ultimate guide packed with information on popular psychedelic drugs like psilocybin, ketamine, MDMA, DMT and LSD—plus practical tips for microdosing and how to safely "trip"—from bestselling author Dr. Rick Strassman. Entering the world of psychedelic drugs can be challenging, and many aren’t sure where to start. As research continues to expand and legalization looms on the horizon for psychedelics like psilocybin, you may need a guide to navigate what psychedelics are, how they work, and their potential benefits and risks. The Psychedelic Handbook is a complete manual that is accessible to anyone with an interest in these “mind-manifesting” substances. Packed with information on psilocybin, LSD, DMT/ayahuasca, mescaline/peyote, ketamine, MDMA, ibogaine, 5-methoxy-DMT (“the toad”), and Salvia divinorum/salvinorin A, this book is your ultimate reference for understanding the science and history of psychedelics; discovering their potential to treat depression, PTSD, substance abuse, and other disorders, as well as to increase wellness, creativity, and meditation; learning how to safely trip and explaining what we know about microdosing; and recognizing and caring for negative reactions to psychedelics. Clinical research psychiatrist, founding figure of the American psychedelic research renaissance, and best-selling author of DMT: The Spirit Molecule, Dr. Rick Strassman shares his experience and perspectives as neither advocate nor foe of psychedelics in order to help readers understand the effects of these remarkable drugs.
One man’s personal journey through the unparalleled trance states of salvia • Originally published as Peopled Darkness • Contains real-life descriptions of salvia-induced visionary experiences • Offers guidance for the responsible use of this psychoactive plant • Explores the shamanic awareness associated with salvia Salvia divinorum, which recently entered the visionary pharmacopoeia of the modern world, has been used for centuries in the shamanic practices of the Mazatec Indians of Oaxaca, Mexico, for healing and divination. A member of the Mint family, Salvia divinorum--“diviner’s sage”--offers a new doorway to the visionary pursuit of higher spiritual and meditative states. With repeated sessions using salvia over the course of several years, J. D. Arthur began returning each time to the same inner landscape where he found himself entering a unique state of thought-free, or “thoughtless,” awareness. There he accessed a mode of “dream language” that communicated an exquisite constellation of detailed meanings swiftly and flawlessly. His repeated immersion in these states of trance, as well as his analysis of their approach and withdrawal, led to a profound reassessment of the nature of normal perception and a reevaluation of what we refer to as the real world. With true-life descriptions of salvia-induced visionary states, this book offers a detailed experiential analysis for those interested in exploring salvia in their quest for higher knowledge.