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Better experimental design and statistical analysis make for more robust science. A thorough understanding of modern statistical methods can mean the difference between discovering and missing crucial results and conclusions in your research, and can shape the course of your entire research career. With Applied Statistics, Barry Glaz and Kathleen M. Yeater have worked with a team of expert authors to create a comprehensive text for graduate students and practicing scientists in the agricultural, biological, and environmental sciences. The contributors cover fundamental concepts and methodologies of experimental design and analysis, and also delve into advanced statistical topics, all explored by analyzing real agronomic data with practical and creative approaches using available software tools. IN PRESS! This book is being published according to the “Just Published” model, with more chapters to be published online as they are completed.
Astrobiology is an expanding, interdisciplinary field investigating the origin, evolution and future of life in the universe. Tackling many of the foundational debates of the subject, from discussions of cosmological evolution to detailed reviews of common concepts such as the 'Rare Earth' hypothesis, this volume is the first systematic survey of the philosophical aspects and conundrums in the study of cosmic life. The author's exploration of the increasing number of cross-over problems highlights the relationship between astrobiology and cosmology and presents some of the challenges of multidisciplinary study. Modern physical theories dealing with the multiverse add a further dimension to the debate. With a selection of beautifully presented illustrations and a strong emphasis on constructing a unified methodology across disciplines, this book will appeal to graduate students and specialists who seek to rectify the fragmented nature of current astrobiological endeavour, as well as curious astrophysicists, biologists and SETI enthusiasts.
Introducing a major new voice in Brazilian letters. Set among a Lebanese immigrant community in the Brazilian port of Manaus, The Brothers is the story of identical twins, Yaqub and Omar, whose mutual jealousy is offset only by their love for their mother. But it is Omar who is the object of Zana's Jocasta-like passion, while her husband, Halim, feels her slipping away from him, as their beautiful daughter, RGnia, makes a tragic claim on her brothers' affection. Vivid, exotic, and lushly atmospheric, The Brothers is the story of a family's disintegration, of a changing city and the culture clash between the native-born inhabitants and a new immigrant group, and of the future the next generation will make from the ruins.
About Trees considers our relationship with language, landscape, perception, and memory in the Anthropocene. The book includes texts and artwork by a stellar line up of contributors including Jorge Luis Borges, Andrea Bowers, Ursula K. Le Guin, Ada Lovelace and dozens of others. Holten was artist in residence at Buro BDP. While working on the book she created an alphabet and used it to make a new typeface called Trees. She also made a series of limited edition offset prints based on her Tree Drawings.
This book offers a comprehensive and accessible introduction to the epistemology of science. It not only introduces readers to the general epistemological discussion of the nature of knowledge, but also provides key insights into the particular nuances of scientific knowledge. No prior knowledge of philosophy or science is assumed by The Nature of Scientific Knowledge. Nevertheless, the reader is taken on a journey through several core concepts of epistemology and philosophy of science that not only explores the characteristics of the scientific knowledge of individuals but also the way that the development of scientific knowledge is a particularly social endeavor. The topics covered in this book are of keen interest to students of epistemology and philosophy of science as well as science educators interested in the nature of scientific knowledge. In fact, as a result of its clear and engaging approach to understanding scientific knowledge The Nature of Scientific Knowledge is a book that anyone interested in scientific knowledge, knowledge in general, and any of a myriad of related concepts would be well advised to study closely.
The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel developments in established techniques for the synthesis of three-membered rings. With its structured composition this is of high interest to scientists in methodological and natural product synthesis as well as those in industrial and pharmaceutical chemistry.
The Cambridge Companion to Judaism and Law provides a conceptual and historical account of the Jewish understanding of law.
Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues