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Recently developed diagnostic and therapeutic technologies such as OCT-angiography and small gauge vitrectomy have influenced the modern treatment of diabetic retinopathy. This volume provides a summary of the state-of-the-art evidence-based approach to managing complications that may occur with diabetic retinopathy. It offers the latest information on pathogenesis and diagnosis, and highly experienced clinicians review the results of relevant randomized clinical trials that serve as the basis of current therapy. The book provides not only a summary of data from randomized trials but also an analysis and interpretation by internationally renowned experts. Ophthalmology residents, fellows, and practicing clinicians will find this book to be a useful reference when seeking evidence-based treatment strategies for various complications of diabetic retinopathy. It is also for researchers identifying new avenues of drug developments and for insurance professionals and health care policy administrators who are establishing evidence-based therapy guidelines for therapeutic intervention.
Structural and functional abnormalities of arteries and veinsmanifest clinically in a broad spectrum of disorders, includinganeurysmal disease, atherosclerosis, vasculitis, venousinsufficiency, microvascular complications, thrombo-embolism andlower limb ulceration. Many of these are common and/orchronic conditions which present for initial assessment by primaryhealth care workers. This new edition is a practical guide to the most commonlypresenting disorders, and provides a structured approach toclinical assessment, investigations and management. The lastfew years have seen major changes in the use of non-invasive orminimally-invasive techniques, e.g wider use of CT and MRangiography, and increasing use of percutaneous interventions forcarotid, lower limb and reno-vascular disease. The ABC of Arterial and Venous Disease (Second Edition)explains the underlying technology and the applications of newminimally-invasive methods, especially CT and MRI, and provides anup-dated, evidence-based guide to the modern day management ofpatients with common, life-threatening diseases involving differentparts of the circulation. This authoritative, full-colour, illustrated ABC is anideal reference for the primary care, non-specialist practitionerto base effective management and prevention programmes.
This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Diabetes mellitus is a metabolic disease characterized by chronic high blood glucose levels. Of the various types of diabetes, type 2 diabetes is increasing in prevalence due to obesity, aging, sedentarism, and other factors. This book presents a novel approach to preventing and treating type 2 diabetes. Chapters cover such topics as diagnosis, pathogenesis, management, lifestyle and nutritional intervention, and systems to support early diagnosis and prevention of prediabetes.
"The recent introduction of optical coherence tomography angiography (OCTA) has remarkably expanded our knowledge of different retinal, chorioretinal, and optic disc disorders. OCTA is nowadays often introduced as a routine exam in clinical practice, granting the opportunity to non-invasively investigate retinal and choroidal circulation. In this book, many major experts in posterior eye imaging share their experiences and their latest images and ideas about OCTA"--
Diabetic retinopathy (DR), a common microvascular complication, has consistently been shown to be associated with an increased risk of cardiovascular disease (CVD). This book provides complete coverage of DR as a potential marker for CVD in those with diabetes. It succinctly reviews the epidemiological and pathogenic links of DR to various cardiovascular events including stroke, coronary artery disease, chronic kidney disease, heart failure, and mortality. Furthermore, it discusses the usefulness of DR in CVD risk prediction and cardiovascular safety of anti-VEGF therapy in diabetic patients. There are insights from contemporary diabetic trials that demonstrated the enhanced cardiovascular benefit of novel glucose lowering therapy. It also highlights the potential of novel retinal imaging to predict CVD and its risk factors using the state-of-the art artificial intelligence-based deep learning systems. This book will be an invaluable resource for specialists translating research findings into clinical care, including those in cardiology, endocrinology, ophthalmology, and general practitioners. IT will also be of interest to public health practitioners, researchers, graduate students, and biotech companies interested in developing retinal image-based diagnostic and prognostic tools.
Featuring over 250 illustrations, this detailed full-color textbook provides up-to-date information on the use of fundus autofluorescence imaging in evaluation of retinal disease. Chapters describe the techniques available to image and quantify fundus autofluorescence and the autofluorescence patterns observed in the healthy eye and in various retinal diseases. Emphasis is on the value of fundus autofluorescence as a diagnostic and prognostic tool and its clinical utility in the context of other imaging techniques, such as fluorescein and indocyanine green angiography and optical coherence tomography. Each chapter also discusses the value of fundus autofluorescence in understanding the pathogenesis of the condition, and provides a comprehensive update on all aspects of the condition. A companion Website will offer the fully searchable text and an image bank.
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
SECTION I: IMAGING MODALITIES: BASIC PRINCIPLES & INTERPRETATION -- 1. Fluorescein angiography -- 2. Indocyanine green angiography -- 3. Optical coherence tomography (OCT) -- -- 4. Optical coherence tomographic ophthalmoscopy -- 5. Ultrasound -- 6. Scanning laser tomography -- 7. Scanning laser polarimetry -- 8. Retinal thickness analyzer -- 9. Adaptive optics ophthalmoscopy -- 10. Imaging of Ocular Blood Flow -- SECTION II: MACULAR DISEASES -- 11. Non-neovascular age-related macular degeneration -- -- 12. Neovascular Age-Related Macular Degeneration -- 13. Pathologic myopia -- 14. Central serous retinopathy -- 15. Macular holes -- 16. Epiretinal membranes -- 17. Macular dystrophies -- 18. Cystoid macular edema -- 19. Angiod streaks -- 20. Chrorioretinal folds -- SECTION III: RETINAL VASCULAR DISEASES -- 21. Diabetic Retinopathy -- 22. Arterial obstructive disease -- 23. Venous obstructive disease -- 24. Parafoveal Telangiectasis -- 25. Coats' disease -- 26. Retinopathy of prematurity -- 27. Ocular ischemic syndrome -- 28. Hypertensive retinopathy -- 29. Radiation retinopathy -- 30. Retinal artery macroanuerysm -- SECTION IV: INFLAMMATORY & INFECTIOUS DISEASES -- 31. Posterior Scleritis -- -- 32. Pars Planitis -- 33. Sarcoidosis -- 34. Uveal Effusion Syndrome -- 35. White Dot Syndromes -- -- 36. Sympathetic Ophthalmia -- 37. Vogt-Koyanagi-Harada Disease -- 38. Syphilis -- 39. Tuberculosis -- 40. Ocular Histoplasmosis -- 41. Fungal Infections -- 42. Endophthalmitis -- 43. Acute Retinal Necrosis -- 44. Toxoplasmosis -- 45. Toxocariasis -- 46. Cysticercosis -- 47. Diffuse Unilateral Subacute Neuroretinitis -- 48. Cytomegalovirus Retinitis -- SECTION V: OTHER RETINAL DISEASES -- 49. Ocular Phototoxicity -- 50. Metabolic and nutritional anomalies -- 51. Medications and Retinal Toxicity -- 52. Retinal injuries -- 53. Hereditary/congenital vitreoretinal disorders -- 54. Retinitis pigmentosa and allied disorders -- SECTION VI: TUMORS -- 55. Retinoblastoma -- 56. Choroidal malignant melanoma -- 57. Choroidal nevus -- 58. Cavernous hemangioma of the retina -- 59. Retinal capillary hemangioma -- 60. Choroidal hemangioma -- -- 61. Tuberous sclerosis complex -- 62. Tumors and related lesions of the retinal pigment epithelium -- 63. Congenital hypertrophy of the retinal pigment epithelium and other pigmented lesions -- 64. Choroidal/retinal metastasis -- 65. Osteomas -- 66. Leukemia /lymphomas -- SECTION VII: OPTIC NERVE DISORDERS -- 67. Optic pits -- 68. Optic nerve head drusen -- 69. Melanocytoma of the optic disc -- 70. Papilledema -- 71. Glaucoma -- 72. Other optic nerve malformations.
Diabetes and Retinopathy brings together the multifaceted information about the research and clinical application from academic, clinical, bioengineering and bioinformatics perspectives. The editors bring together a stellar cast of authors to pull together this diverse and interesting field. Academic researchers, bioengineers, new investigators and students interested in diabetes and retinopathy need an authoritative reference to bring this multidisciplinary field together to reduce the amount of time spent on source-searching and more time on actual research and the clinical application. This reference depicts the current clinical understanding of DR as well as the many scientific advances in understanding this condition. - Provides valuable information for academic clinicians, researchers, bioengineers and industry on diabetes and retinopathy - Discusses the impact of diabetic retinopathy, a major cause of new-onset visual loss in all the industrialized nations - Covers statistical classification techniques and risk stratification