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Drug repurposing is the development of existing drugs for new uses: given that 9 in 10 drugs that enter drug development are never marketed and therefore represent wasted effort, it is an attractive as well as inherently more efficient process. Three repurposed drugs can be brought to market for the same cost as one new chemical entity; and they can also be identified more quickly, an important benefit for patients whose diseases are progressing faster than therapeutic innovation. But repurposing also requires a fresh look at configuring pharmaceutical R&D, considering clinical, regulatory and patent issues much earlier than would otherwise be the case; a holistic gedanken experiment almost needs to be undertaken at the very start of any repurposing development. In addition to new ways of thinking, the discovery of repurposing opportunities can take advantage of artificial intelligence techniques to match the perfect new use for an existing drug. And while repurposing of medicines has been in the mind of every doctor since Hypocrates, modern clinical practice will simply have to adapt to new repurposing techniques in an age where the number of known diseases is increasing much faster than the healthcare dollars available.
"Country Living contributing editor Randy Florke shows how to decorate and renovate a home inexpensively with repurposed, restored, and recycled materials. Providing inspiration and practical information, he perfectly captures why sustainable living is important and reveals how everyone can create a home that's a harmonious with the environment as it is beautiful. What's more, 'Restore. Recycle. Repurpose.' explains how to do it without buying costly materials from far-flung places or throwing out what you already have. Room by room, Florke presents ideas, examples, and resources that are "shades of green." His approach begins with a major focus for each room, such as vanities, sinks, and tubs in the bathroom. Sharing his flea market and thrift shopping skills as well as some savvy wisdom inspired by his grandmother, Florke will help you create a welcoming, lovely, earth-friendly décor--without spending a fortune"--P. [2] of cover.
'From the founder of OzHarvest, an ebullient, generous memoir with an exhilarating message.' ANNABEL CRABB 'Brimming with energy, altruism and refreshing candour' QUENTIN BRYCE 'The inspiring story of a woman with a big heart who dared to make a difference. This is a must-read book. I couldn't put it down.' ITA BUTTROSE 'Ronni Kahn is a force of nature. She has taught so many of us about the importance of embracing community and compassion through offering and sharing our food to those most vulnerable in our society.' KYLIE KWONG 'You don't get used to living permanently behind the eight ball - no matter how long you've done it, it doesn't get easier. There's a constant sense of shame that eats away at you, making you feel that you're just not good enough. Some people are so poor that they can't even afford to feel shame. Ronni Kahn, through her work with OzHarvest, does the very thing that offers hope to those in the poverty trap: restore dignity and remove shame. This is her story.' JIMMY BARNES 'Ronni Kahn is a one-woman freight train for the force of good. She is living testament to the awesome power of living in a way that is real and wholehearted, and whether people know it or not, that is why they are drawn to her. This book is not only a beautifully conveyed account of Ronni's story, but it also serves as inspiration for anyone who chooses to see life's challenges as opportunities to grow. Through serving others, there is the very real possibility we may find a sense of purpose, connectedness and joy.' MELISSA LEONG 'Inspiring, wonderfully honest and very much needed.' TIM FLANNERY Life throws us mysterious ingredients. If we are brave enough to put the recipe aside and experiment, it's right there that things get interesting. As the owner of a successful events company, throwing away huge volumes of leftover food at the end of the day came with the territory. But when Ronni Kahn hit midlife, she found herself no longer able to turn a blind eye to her food waste problem. Hand delivering the untouched food to homeless shelters around Sydney became her renegade solution. Little did she know that fixing her small problem at work would lead her to unlock a hidden purpose at the very core of her inner life. Now founder and CEO of the food rescue organisation OzHarvest, Ronni leads hundreds of staff and thousands of volunteers with the goal to nourish Australia. She serves in an advisory capacity to government and is an instrumental leader in changing federal laws to improve social justice and environmental policies. A Repurposed Life is the story of how Ronni found her voice, her heart and her deepest calling. From her early years growing up under the brutal system of apartheid South Africa, to a socialist commune in Israel, Ronni finally settled in Australia to discover a profound new way of living. Shared with the humour, warmth and energy that have made her an internationally renowned keynote speaker, this heartfelt exploration of the choices that define us will speak to anyone seeking a more passionate expression of being alive.
Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types
Nazi Submarines? Life-and-death battles with huge rats? The Cuban Missile Crisis? The assassination of JFK? These are not the predictable topics you'd typically associate with a book that appears to be about cleaning up toxic, abandoned industrial sites, urban redevelopment, economic growth, and job creation. But if your name is Bob White, they're all part of an improbable journey from naive farm boy, to Cold War-era U.S. Marine, to the executive directorship of the Redevelopment Authority of the County of Bucks. He's been referred to as "a beefy, fast-talking construction expert," a "larger-than-life visionary," "a superstar in economic development," and numerous other glowing accolades by Bucks County's press, politicians, and redevelopment and real estate industry executives. There's good reason for that: During Bob White's tenure at the helm of Bucks County's Redevelopment Authority, more than 50 large-scale, transformative projects were completed and over 20,000 jobs were saved or generated in the process. Dozens of environmentally contaminated, blighted buildings-relics from the county's past glory years as a major East Coast manufacturing center-were replaced by beautiful parks, sparkling office complexes, research centers, upscale residential communities, new roadways, and a thriving deepwater port. Repurposing the Past is HGTV on an industrial scale. In addition to Bob's unique and inspiring story, this new and unique book gives you a ringside seat to several dozen of his most significant, far-reaching projects. More than 80 photos provide a before and after look at each site, along with a narrative depicting its history, the environmental challenges and remediations involved, and the demolitions, budgets, grants, redevelopment plans, and community and political participation that helped Bucks County boldly step into the 21st century. Whether you're a student or a professional in the fields of environmental sciences, economic development, and urban studies, or you're simply looking to read a unique, inspiring story, Repurposing the Past will prove to be a page turner.
Drug development can be time-consuming and expensive. Recent estimates suggest that, on average, it takes 10 years and at least $1 billion to bring a drug to market. Given the time and expense of developing drugs de novo, pharmaceutical companies have become increasingly interested in finding new uses for existing drugs - a process referred to as drug repurposing or repositioning. Historically, drug repurposing has been largely an unintentional, serendipitous process that took place when a drug was found to have an offtarget effect or a previously unrecognized on-target effect that could be used for identifying a new indication. Perhaps the most recognizable example of such a successful repositioning effort is sildenafil. Originally developed as an anti-hypertensive, sildenafil, marketed as Viagra and under other trade names, has been repurposed for the treatment of erectile dysfunction and pulmonary arterial hypertension. Viagra generated more than $2 billion worldwide in 2012 and has recently been studied for the treatment of heart failure. Given the widespread interest in drug repurposing, the Roundtable on Translating Genomic-Based Research for Health of the Institute of Medicine hosted a workshop on June 24, 2013, in Washington, DC, to assess the current landscape of drug repurposing activities in industry, academia, and government. Stakeholders, including government officials, pharmaceutical company representatives, academic researchers, regulators, funders, and patients, were invited to present their perspectives and to participate in workshop discussions. Drug Repurposing and Repositioning is the summary of that workshop. This report examines enabling tools and technology for drug repurposing; evaluates the business models and economic incentives for pursuing a repurposing approach; and discusses how genomic and genetic research could be positioned to better enable a drug repurposing paradigm.
In with the old, out with the new—reclaiming your closet and reducing fashion waste starts here. Repair your favorite socks with style, add flair with personalized patches, and turn ripped jeans into an embroidered masterpiece. For beginner and experienced makers, Lily Fulop's guide to mending and upcycling is your colorful companion to ditching fast fashion and extending the lifecycle of all your favorite clothes. Fulop's vibrant step-by-step illustrations make mending easier than every, demystifying techniques and displaying unique ways to show off your personality. And when your mending possibilities run out, she has simple yet striking solutions to repurpose fabric, including braided rugs, crocheted pillows, and more. Say hello to sustainable inspiration.
The green belt has been one of the UK’s most consistent and successful planning policies. Over the past century, it has limited urban sprawl and preserved the countryside around our cities, but is it still fit for purpose in a world of unprecedented urban growth and potentially catastrophic climate change? Repurposing the Green Belt in the 21st Century examines the history of the green belt in the UK and how it has influenced planning regimes in other countries. Despite its undoubted achievements, it is time to review the green belt as an instrument of urban planning and landscape design. The problem of the ecological impact of cities and the mitigation measures of major climate changes are at the top of the urban agenda across the world. Urban agriculture, blue and green infrastructures, and forestation are the new ecological design imperatives driving urban policymaking.
"Stenberg responds to the neoliberal discourse that pervades academe through the vernacular practice of repurposing. She demonstrates how tactics informed by feminist praxis can repurpose current writing pedagogy, assessment, and public engagement. Stenberg disrupts the entrenched mode of neoliberalism enacted through local practices in the classroom using feminist scholarship's history of repurposing seemingly "neutral" practices"--
A DIY book making guide that repurposes easily-found items into handcrafted books, perfect for gift giving. Re-Bound is a beautiful book on bookbinding with a fun green twist—all the projects use recycled and upcycled materials. This book shows you how to take everyday materials from around the house, flea markets, thrift stores, and hardware stores and turn them into clever and eye-catching hand-made books.