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This book gives a comprehensive overview of the recent advancements and developments of rapid diagnostic tests (RDTs) and technologies, which are quite novel approaches and might be used as laboratory bench manual for the rapid diagnosis of the various disease conditions. The book focuses on various aspects and properties of RDTs, point-of-care tests (POCTs), quality control, assurance, calibration, safety, nano-/microfluidic technologies, and fusion with DNA technologies. I hope that this work might increase the interest in this field of research and that the readers will find it useful for their investigations, management, and clinical usage.
Technology assessment can lead to the rapid application of essential diagnostic technologies and prevent the wide diffusion of marginally useful methods. In both of these ways, it can increase quality of care and decrease the cost of health care. This comprehensive monograph carefully explores methods of and barriers to diagnostic technology assessment and describes both the rationale and the guidelines for meaningful evaluation. While proposing a multi-institutional approach, it emphasizes some of the problems involved and defines a mechanism for improving the evaluation and use of medical technology and essential resources needed to enhance patient care.
Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.
Smartphones for Chemical Analysis: From Proof-of-Concept to Analytical Applications, Volume 101 in the Comprehensive Analytical Chemistry series, highlights new advances in this broadening field, with chaters that cover Smartphone-based assay benchmarking using traditional instrumental analysis, Smartphone-based water analysis, Sample preparation in smartphone-based analysis: Current status and challenges, Application of smartphone-based analysis in the medical field, Smartphone-based biosensors in the food analysis field, Bioreceptors for smartphone detection, Smartphone "anatomy": Features used for ubiquitous sensing, and much more. Additional chapters cover End-user integration for at-home analysis, Hyphenating paper-based biosensors with smartphones, Smartphone based Fluorescent and chemiluminescent sensing, Smartphones for portable surface enhanced raman spectroscopy, Towards a universal applicable photonics approach and sustainable spectral data, Integrating blockchain and image analyses on smartphones to create a secure food export pipeline, Smartphone-based electrochemical (bio)sensors: state of the art and perspective, Micro-and nanoplastic detection through a point of site platform platform, and Benchmarking using ambient mass spectrometry. - Provides up-to-date, expert opinion on this emerging topic - Covers a wider range of the chemical analysis field, from food to medical analysis - Highlights current challenges with solutions proposed
This handbook comprehensively reviews different nanomaterials and modern electrochemical approaches used in the point-of-care analysis of biomolecules. It describes the importance, significance, and application of various kinds of smart nanomaterials and their integration with modern electrochemical techniques for the point-of-care diagnosis of biologically important biomolecules. The interaction between bio-systems and nanomaterials have been discussed in this book using advanced electrochemical methods and characterizing techniques. It describes the combination of classical and modern methodologies for the synthesis of metal nanoparticles/nanoclusters and modern electrochemical techniques for the early-stage detection and point-of-care diagnosis of cancer and other infectious disease such as SARS, influenza, tuberculosis (TB), and hepatitis. Finally, the book provides an accessible and readable summary of the use of nanomaterial for understanding the electrochemical reaction taking place at nano-bio interfaces in electrochemical biomolecular detection and analysis. The book bridges the gap and strengthens the relationship between electrochemists, material scientists, and biomolecular scientists who are directly or indirectly associated with the field of such point-of-care diagnostics. ​
Carbon-Based Nanomaterials for Sustainable and Technological Applications covers the fundamentals of carbon-based nanomaterials (CNMs) and their potential for technological and industrial applications. Addressing recent advancements in technology and improvement in material synthesis, the book outlines how functionalized CNMs are used in nanobiotechnology, for active sorbent materials, and in pharmaceutical applications. Chapters cover macro-scale applications, biosensors and drug delivery, and treatment in cancer and coronavirus diseases. Key features: Through up-to-date references, this book demonstrates that carbon-based nanomaterials are one of the most promising nanomaterials in medical applications, such as drug and gene delivery carriers, as well as nonmedical, environmental applications. Discusses the synthesis methods of processing (CQDs), (GQDs), (CPDs), and (g-C3N4) materials-based nanocomposites for biotechnological applications. Chapters address various classes of carbon nanomaterials and their innovative technologies. Opens up further exploration of environmental nanotechnology, bionanotechnology, and biomedical applications of novel carbon nanomaterials. Full references can be found via the Support Material: www.routledge.com/9781032635934. Written by a leading expert, this volume provides the reader with thorough coverage of bionanotechnology and biomedical applications of novel carbon nanomaterials.
Evolving Landscape of Molecular Diagnostics: Applications and Techniques presents cutting-edge reviews on current and emerging technologies in the diagnosis of microbial infections. The book discusses the fundamentals of Molecular Diagnostics for bacteria, fungi, viruses and a variety of state-of-the-art diagnostics tools and techniques for obtaining qualitative and quantitative results. It includes topics such as Next generation sequencing and application of "OMICS" for early disease diagnosis. Sections cover the entire spectrum of emerging diagnostic tools and techniques, as well as the principles, pros and cons of each method and applications for diagnosis of infectious disease in plants, humans and veterinary. This is a resource for both researchers and students working in clinical microbiology, infectious biology, applied life sciences and scientists working in the clinical diagnostic industry. - Provides a wide range of diagnostics tools and technologies in the field of infectious biology - Presents discussions on emerging technologies for early disease diagnosis and novel diagnostics techniques for detection of COVID, Urea Breath Tests for Detection of Helicobacter pylori, Loop-Mediated Isothermal Amplification as Point-of-Care Diagnosis, Molecular imaging, Lab-on-a-chip Technologies, and several others - Analyzes literature reviews, underpinning methodologies, and opportunities and limitations - Includes case studies and examples that highlight applications using the underpinning techniques
Molecular Detection of Animal Viral Pathogens presents expert summaries on state-of-the-art diagnostic approaches for major animal viral pathogens, with a particular emphasis on identification and differentiation at the molecular level. Written by specialists in related research areas, each chapter provides a concise overview of an individual virus
The inappropriate use of antibiotics is a primary cause of the ongoing increase in drug resistance amongst pathogenic bacteria. The resulting decrease in the efficacy of antibiotics threatens our ability to combat infectious diseases. Rapid point-of-care tests to identify pathogens and better target the appropriate treatment could greatly improve the use of antibiotics. Yet there are few such tests currently available or being developed despite the rapid pace of medical innovation. Clearly something is inhibiting the much-needed development of new and more convenient diagnostic tools. This study delineates priorities for developing diagnostics to improve antibiotic prescription and use with the goal of managing and curbing the expansion of drug resistance. It calls for new approaches particularly in the provision of diagnostic devices and in doing so outlines some of the inadequacies in health science and policy initiatives that have led to the dearth of such devices. The authors make the case that there is a clear and urgent need for innovation not only in the technology of diagnosis but also in public policy and medical practice to support the availability and use of better diagnostic tools. This book explores the complexities of the diagnostics market from the perspective of both supply and demand unearthing interesting bottlenecks some obvious some more subtle. It calls for a multifaceted and broad policy response and an overhaul of current practice so that the growth of bacterial resistance can be stemmed.