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This textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader’s bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. The textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics.
New consumer technology is empowering us to take control of our day-to-day health. Leading tech writer Richard MacManus looks at what is out there now and what is in development, and what this might mean for our health in the future. Health Trackers tells the story of the rise of self-tracking — the practice of measuring and monitoring one’s health, activities or diet. Thanks to new technologies, such as smartphone apps and personal genomics, self-tracking is revolutionizing the health and wellness industries. Through interviews with tech developers, early adopters and medical practitioners, Richard MacManus explores what is being tracked, what tools and techniques are being used, the best practices of early adopters, and how self-tracking is changing healthcare. The first eight chapters focus on a particular type of, or approach to, self-tracking, for example, diet, daily activity and genetics. The final two chapters look at how the medical establishment is adopting, and adapting to, self-tracking. This timely book covers technologies still early in their evolution but poised to go mainstream, and rather than look at how to use specific gadgets, it focuses on the philosophy and usefulness of self- tracking in its many forms. Many of us are curious about it, but don’t understand the benefits (and sometimes risks) of these tools and practices. With no comparable book on the market, Trackers is the first to focus on consumer technologies and to help ordinary people negotiate the new health landscape.
Collected here are the best of 10 years' worth of essays from ideonexus.com covering science culture, Enlightenment ethics, skeptical inquiry, and celebration of natural wonders.
Internationally acclaimed science writer Lone Frank swabs up her DNA to provide the first truly intimate account of the new science of consumer-led genomics. She challenges the business mavericks intent on mapping every baby's genome, ponders the consequences of biological fortune-telling, and prods the psychologists who hope to uncover just how much or how little our environment will matter in the new genetic century - a quest made all the more gripping as Frank considers her family's and her own struggles with depression.
A thorough cross-disciplinary exploration of the implications of genomics-influenced educational practice, for consideration by scientists, practitioners and laypersons alike.
"For all those who fear they cannot understand the science of DNA -- they will soon find that they can and it's fascinating." -- Matt Ridley, author of Genome: The Autobiography of a Species in 23 Chapters DNA, once the exclusive domain of scientists in research labs, is now the darling of popular and social media. With personal genetic testing kits in homes and GMO foods in stores, DNA is an increasingly familiar term. Unfortunately, what people know, or think they know, about DNA and genetics is often confused or incorrect. Contrary to popular belief, for instance, genes don't "skip a generation" and, no, human DNA is not "different" from DNA of other species. With popular misconceptions proliferating in the news and on the internet, how can anyone sort fact from fiction? DNA Demystified satisfies the public appetite for and curiosity about DNA and genetics. Alan McHughen, an accomplished academic and public science advocate, brings the reader up-to-speed on what we know, what we don't, and where genetic technologies are taking us. The book begins with the basic groundwork and a brief history of DNA and genetics. Chapters then cover newsworthy topics, including DNA fingerprinting, using DNA in forensic analyses, and identifying cold-case criminals. For readers intrigued by the proliferation of at-home DNA tests, the text includes fascinating explorations of genetic genealogy and family tree construction-crucial for people seeking their biological ancestry. Other chapters describe genetic engineering in medicine and pharmaceuticals, and the use of those same technologies in creating the far more controversial GMOs in food and agriculture. Throughout, the book raises provocative ethical and privacy issues arising from DNA and genetic technologies. With the author's comprehensive expertise, DNA Demystified offers an informal yet authoritative guide to the genetic marvel of DNA.
In 2000, President Bill Clinton signaled the completion of the Human Genome Project at a cost in excess of $2 billion. A decade later, the price for any of us to order our own personal genome sequence--a comprehensive map of the 3 billion letters in our DNA--is rapidly and inevitably dropping to just $1,000. Dozens of men and women--scientists, entrepreneurs, celebrities, and patients--have already been sequenced, pioneers in a bold new era of personalized genomic medicine. The $1,000 genome has long been considered the tipping point that would open the floodgates to this revolution. Do you have gene variants associated with Alzheimer's or diabetes, heart disease or cancer? Which drugs should you consider taking for various diseases, and at what dosage? In the years to come, doctors will likely be able to tackle all of these questions--and many more--by using a computer in their offices to call up your unique genome sequence, which will become as much a part of your medical record as your blood pressure.
This edited book showcases original research in the study of healthcare and health communication, while also providing a detailed overview of contemporary methods of discourse analysis. Discourse approaches remain under-represented in the field of health communication, despite their potential for affording detailed understanding of health-related text and talk across an array of contexts, for example in face-to-face and digital healthcare encounters, health promotion, and patients’ accounts of illness experiences. This book aims to address this gap in the literature by offering the first book-length treatment of different approaches to discourse analysis in health(care) and illness contexts, and it will appeal both to linguists and to researchers in nursing and health sciences, sociology and anthropology.
The impact of information technology on the management of healthcare has been enormous in recent years, and it continues to grow in scope and complexity. This book presents papers from the 2014 International Conference on Informatics, Management, and Technology in Healthcare (ICIMTH), held in Athens, Greece, in July 2014. The book includes 79 full papers and 12 poster presentations as well as keynotes, two workshops and three tutorials. Papers are divided into sections including: clinical informatics; decision support and intelligent systems; e-learning and education; health informatics, information management and technology assessment; healthcare IT; mobile technology in healthcare; public health informatics and issues; social and legal issues; and telemedicine. The book will be of interest to all those whose work involves the use of biomedical and health informatics.