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This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.
Natural Products in the Chemical Industry is not a conventional textbook, but rather an invitation to join an entertaining journey that takes you into the fascinating world of natural products. This book features diverse compound classes from a number of areas: colourants, fragrances and flavourings, amino acids, pharmaceuticals, hormones, vitamins and agrochemicals. Whether you are a teacher or a scholar, an undergraduate or graduate student, a professional chemist in industry or academia, or someone just interested in natural sciences, this book allows you to be inspired and entertained by facts and information along with enjoyable anecdotes, historical, economic, political, biological and social considerations. Experts in the field can have a pleasurable time cruising through captivating synthesis methods, which enable the generation of complex molecules on industrial scale. This book · deals with the manufacturing of larger quantities of complex molecules (asymmetric and heterocyclic compounds, polycyclic structures, macrocycles and small rings) · displays all reaction schemes in colour, which makes them easy to read · highlights aesthetics and elegance in modern industrial organic chemistry
The book summarizes the state-of-the-art of research on control of self-organizing nonlinear systems with contributions from leading international experts in the field. The first focus concerns recent methodological developments including control of networks and of noisy and time-delayed systems. As a second focus, the book features emerging concepts of application including control of quantum systems, soft condensed matter, and biological systems. Special topics reflecting the active research in the field are the analysis and control of chimera states in classical networks and in quantum systems, the mathematical treatment of multiscale systems, the control of colloidal and quantum transport, the control of epidemics and of neural network dynamics.
Following to previous OWLS conferences devoted to widespread applications of optics in life sciences, this 5th OWLS Conference focuses on recent achievements in applying lasers and optics in biomedicine and the preservation of our cultural heritage. Particular attention is paid to laser diagnostics in medicine, interaction of laser radiation with biological tissue, aspects of the preservation of cultural heritage, and the development of new systems for these studies. The contributors to this volume cover international research activities in the following areas: Laser-tissue interactions and tissue optics - photon migration in tissue; Medical sensors - fiber optics; Clinical use of lasers (dermatology, ENT, cardiology, etc.); Laser-based techniques in art conservation (cleaning, diagnostics, analytical applications); Imaging techniques and lasers in archaeology; Laser technologies in contemporary art (holography, marking, etc.); and New laser and opto-electronic systems for biomedical and art-related studies.
A new class of insulating solids was recently discovered. Whenirradiated by a few visible photons, these solids give rise to amacroscopic excited domain that has new structural and electronicorders quite different from the starting ground state. This occurrenceis called photoinduced phase transition, and this multi-authoredbook reviews recent theoretical and experimental studies of this newphenomenon.
This book defines and discusses the term “hidden geographies” in two ways: systematically and by presenting a variety of examples of the research fields and topics concerning hidden geographies, with the aim of stimulating further basic and applied research in this area. While the term is quite rarely used in the scientific literature (more often as a figure of speech than to illustrate or problematize its deeper meaning), we argue that hidden geographies are everywhere and many of them have significant impacts on (other) natural and social phenomena and processes, subsequently triggering changes, for example in landscape, economy, culture, health or quality of life. The introductory section of the book conceptualises hidden geographies and discusses cognitive geography, symbolization of space, and the hidden geographies in mystical literature. Case studies of hidden environmental geographies address soils, air pollution, coastal pollution and the allocation of an astronomical tourism site. Revealing hidden historical and sacred places is illustrated through examples of the visualisation of the subterranean mining landscape, the analysis of the historical road network and trade, border stones and historical spatial boundaries, and the monastic Carthusian space. Hidden urban geographies are discussed in terms of the urban development of an entire city, presenting the role of geography in rescuing architecture, revealing illegal urbanisation, and the quality of habitation in Roma neighbourhoods. Case studies of hidden population geographies shed light on the ageing of rural populations and the impact of spatial-demographic disparities on fertility variations. Discussions of hidden social and economic geographies problematize recent social changes and conflicts in a country, present the implementation of the fourth industrial revolution and borders as hidden obstacles in the organisation of public transport. Hidden geographies are explicitly linked to perceptions and explanations in case studies that address local responses to perceived marginalisation in a city, the solo women travellers’ perceived risk and safety, and hidden geographical contexts of visible post-war landscapes. The book brings such a diversity of views, ideas and examples related to hidden geographies that can serve both to deepen their understanding and their various impacts on our lives and environment, and to attract further cross-disciplinary interest in considering hidden geographies – in research and in our every-day lives.
This book offers one of the most comprehensive reviews in the field of gastrointestinal (GI) physiology, guiding readers on a journey through the complete digestive tract, while also highlighting related organs and glandular systems. It is not solely limited to organ system physiology, and related disciplines like anatomy and histology, but also examines the molecular and cellular processes that keep the digestive system running. As such, the book provides extensive information on the molecular, cellular, tissue, organ, and system levels of functions in the GI system. Chapters on the roles of the gut as an endocrine, exocrine and neural organ, as well as its microbiome functions, broaden readers’ understanding of the multi-organ networks in the human body. To help illustrate the interconnections between the physiological concepts, principles and clinical presentations, it outlines clinical examples such as pathologies that link basic science with clinical practice in special “clinical correlates” sections. Covering both traditional and contemporary topics, it is a valuable resource for biomedical students, as well as healthcare and scientific professionals.
“Don’t start an art collective until you read this book.” —Guerrilla Girls “Ever since Web 2.0 with its wikis, blogs and social networks the art of collaboration is back on the agenda. Collectivism after Modernism convincingly proves that art collectives did not stop after the proclaimed death of the historical avant-gardes. Like never before technology reinvents the social and artists claim the steering wheel!” —Geert Lovink, Institute of Network Cultures, Amsterdam “This examination of the succession of post-war avant-gardes and collectives is new, important, and engaged.” — Stephen F. Eisenman, author of The Abu Ghraib Effect “Collectivism after Modernism crucially helps us understand what artists and others can do in mushy, stinky times like ours. What can the seemingly powerless do in the face of mighty forces that seem to have their act really together? Here, Stimson and Sholette put forth many good answers.” —Yes Men Spanning the globe from Europe, Japan, and the United States to Africa, Cuba, and Mexico, Collectivism after Modernism explores the ways in which collectives function within cultural norms, social conventions, and corporate or state-sanctioned art. Together, these essays demonstrate that collectivism survives as an influential artistic practice despite the art world’s star system of individuality. Collectivism after Modernism provides the historical understanding necessary for thinking through postmodern collective practice, now and into the future. Contributors: Irina Aristarkhova, Jesse Drew, Okwui Enwezor, Rubn Gallo, Chris Gilbert, Brian Holmes, Alan Moore, Jelena Stojanovi´c, Reiko Tomii, Rachel Weiss. Blake Stimson is associate professor of art history at the University of California Davis, the author of The Pivot of the World: Photography and Its Nation, and coeditor of Visual Worlds and Conceptual Art: A Critical Anthology. Gregory Sholette is an artist, writer, and cofounder of collectives Political Art Documentation/Distribution and REPOhistory. He is coeditor of The Interventionists: Users’ Manual for the Creative Disruption of Everyday Life. “To understand the various forms of postwar collectivism as historically determined phenomena and to articulate the possibilities for contemporary collectivist art production is the aim of Collectivism after Modernism. The essays assembled in this anthology argue that to make truly collective art means to reconsider the relation between art and public; examples from the Situationist International and Group Material to Paper Tiger Television and the Congolese collective Le Groupe Amos make the point. To construct an art of shared experience means to go beyond projecting what Blake Stimson and Gregory Sholette call the “imagined community”: a collective has to be more than an ideal, and more than communal craft; it has to be a truly social enterprise. Not only does it use unconventional forms and media to communicate the issues and experiences usually excluded from artistic representation, but it gives voice to a multiplicity of perspectives. At its best it relies on the participation of the audience to actively contribute to the work, carrying forth the dialogue it inspires.” —BOMB
During the Meiji Era, of 1868-1912, British influence in Japan was stronger than that of any other foreign power. Although role models were sought from Englishmen and Scotsmen, whether diplomats, engineers, educators or philosophers, the first priority for the Japanese was to achieve a transfer of industrial and technical skills. As important customers, who brought good profits to British industry, the Japanese were accommodated when they stipulated on awarding a contract that their own people should work in office, shipyard or factory. Much new research material discovered in Japan, England and Scotland has enabled the detailed examination of a relationship - with Britain as Senior and Japan as Junior partner - which lasted until 1914. It was on these foundations that Japan was able subsequently to build a great industrial nation.
Basic instinct of selfishness of human beings is the root cause of all the problems in the modern society. The enormous power of observation-based hypothesis, experimentation and extrapolation of results provided the success of humans in developing the technologies beyond imagination. Power of mind determinesdiscretionary attitude and behavior of individuals in the society. Culturing of the right attitudes in the young and youth needs to be imparted by quality education. All round development of young ones into responsible citizens of the globe can be accomplished with the right type of education consisting of Literature, Sociology, Mathematics, Economics, Science and Technology as well as Spirituality as important components. To address these issues insight opinions of eminent personalities across the continents are included in the volume entitled "Insights on GlobalChallenges and Opportunities for the Century Ahead"has been brought outon theoccasion of celebrating 25, 50 and 100 years of establishmentof Centre for Plant Molecular Biology (CPMB), Department of Genetics, and Osmania University, respectively.