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The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter reviews key terms, tests for understanding basic concepts, and poses research-based problems. The Problems Book has be
A textbook that integrates molecular biology, biochemistry, and cell biology into a unified course of study, reflecting the shift in emphasis of molecular biology from a concentration on genes for their own sake to the application of molecular genetic studies to all areas of cell biology and bioche.
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. - Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features - Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration - Details features, advantages and limitations of animal models, as well as prospects for therapeutic development - Authored by internationally recognized leaders in the field - Includes illustrations that help clarify and consolidate complex concepts
A masterful introduction to the cell biology that you need to know! This critically acclaimed textbook offers you a modern and unique approach to the study of cell biology. It emphasizes that cellular structure, function, and dysfunction ultimately result from specific macromolecular interactions. You'll progress from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states. The exquisite art program helps you to better visualize molecular structures. Covers essential concepts in a more efficient, reader-friendly manner than most other texts on this subject. Makes cell biology easier to understand by demonstrating how cellular structure, function, and dysfunction result from specific macromole¬cular interactions. Progresses logically from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states. Helps you to visualize molecular structures and functions with over 1500 remarkable full-color illustrations that present physical structures to scale. Explains how molecular and cellular structures evolved in different organisms. Shows how molecular changes lead to the development of diseases through numerous Clinical Examples throughout. Includes STUDENT CONSULT access at no additional charge, enabling you to consult the textbook online, anywhere you go · perform quick searches · add your own notes and bookmarks · follow Integration Links to related bonus content from other STUDENT CONSULT titles—to help you see the connections between diverse disciplines · test your knowledge with multiple-choice review questions · and more! New keystone chapter on the origin and evolution of life on earth probably the best explanation of evolution for cell biologists available! Spectacular new artwork by gifted artist Graham Johnson of the Scripps Research Institute in San Diego. 200 new and 500 revised figures bring his keen insight to Cell Biology illustration and further aid the reader’s understanding. New chapters and sections on the most dynamic areas of cell biology - Organelles and membrane traffic by Jennifer Lippincott-Schwartz; RNA processing (including RNAi) by David Tollervey., updates on stem cells and DNA Repair. ,More readable than ever. Improved organization and an accessible new design increase the focus on understanding concepts and mechanisms. New guide to figures featuring specific organisms and specialized cells paired with a list of all of the figures showing these organisms. Permits easy review of cellular and molecular mechanisms. New glossary with one-stop definitions of over 1000 of the most important terms in cell biology.
As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.
Now you can tailor the Seventh Edition of Biology: The Unity and Diversity of Life specifically to the topics you cover in your course. Six paperbacks are available: Cell Biology and Genetics, Evolution of Life, Plant Structure and Function, Animal Structure and Function, and Ecology and Behavior.The Cell Biology and Genetics volume includes characteristics of life, scientific methods, basic chemistry, cell biology, metabolism, mitosis and meiosis, classical genetics, human genetics, molecular genetics, recombinant DNA, and genetic engineering. (In the hardcover version, Units I and II, Chapters 1-16.).
In this issue, guest editors bring their considerable expertise to this important topic. - Contains 16 practice-oriented topics including critical care of the burn patient; acute surgical management of the burn patient; critical care rehabilitation of the burn patient; scar management and reconstructive surgery; the first 24 hours: resuscitation and early complications in burn patients; and more. - Provides in-depth clinical reviews on burn management, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
"Darwin (1871) and many African folk legends before him [...] proposed a simple but powerful explanation for the large and elongated shape. Long necks allowed giraffe to outreach presumed competitors, particularly during dry-season bottlenecks when leaves become scarce; (Simmons and Scheepers). However, this old African folk legend which is still commonly taught in high schools, fails to explain, among other things, the size differences between males and females. Giraffe cows are up to 1.5 meters shorter than the giraffe bulls, not to mention the offspring. The wide migration range of the giraffe and the low heights of the most common plants in their diet likewise argue against the dominant selection hypothesis. Also: 1) The fossil "links," which according to the theory should appear successively and replace each other, usually exist simultaneously for long periods of time. 2) Evolutionary derivations based on similarities rely on circular reasoning. 3) The giraffe has eigh t cervical vertebrae. Although the 8th vertebra displays almost all the characteristics of a neck vertebra, as an exception to the rule the first rib pair is attached there. 4) The origin of the long-necked giraffe by a macromutation is, due to the many synorganized structures, extremely improbable. 5) Sexual selection also lacks a mutational basis and, what is more, is frequently in conflict with natural selection ("head clubbing" is probably "a consequence of a long neck and not a cause"; see also Mitchell et al. 2009). 6) In contrast to the thus-far proposed naturalistic hypotheses, the intelligent design theory is basically testable. 7) The long-necked giraffes possibly all belong to the same basic type inasmuch as 8) a gradual evolution from the short-necked to the long-necked giraffe is ruled out by the duplication of a neck vertebra and the loss of a thoracic vertebra. 9) Chance mutations are principally not sufficient to explain the origin of the long-necked giraffe. 10) The intelligent design theory offers an adequate and satisfying solution to the problems and points to numerous "old" and new research projects. 11) Mitchell and Skinner present a good analysis of the selectionist problem; however, their phylogenetic hypotheses presuppose the correctness of the synthetic evolutionary theory, and their claims of "intermediate forms" are unproven (similarly summary Part 2). Part 1 shows why Dawkins and Kutschera are wrong. The scientific facts speak for design."
With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 7th Edition helps you understand the most important and the most complex pathophysiology concepts. More than 1,200 full-color illustrations and photographs make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW Epigenetics and Disease chapter along with additional What’s New boxes highlighting the latest advances in pathophysiology. Written by well-known educators Kathryn McCance and Sue Huether, and joined by a team of expert contributors, this resource is the most comprehensive and authoritative pathophysiology text available! Over 1,200 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes — more than in any other pathophysiology text. A fully updated glossary includes 1,000 terms, and makes lookup easier by grouping together similar topics and terms. Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition. Chapter summary reviews provide concise synopses of the main points of each chapter. Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. Algorithms and flowcharts of diseases and disorders make it easy to follow the sequential progression of disease processes. Nutrition and Disease boxes explain the link between concepts of health promotion and disease. Updated content on leukocytes in pain modulation, seizure disorders, brain injuries and disorders, acute encephalopathies, reproductive disorders, and much more keep you at the cutting edge of this constantly changing field. What’s New? boxes highlight the most current research and findings to ensure you have the most up-to-date information. New animations, review questions, Key Points, and an audio glossary have been added to the Evolve companion website to strengthen your understanding of key concepts. Media Resources Lists encourage you to develop a study plan to master the important content in each chapter.