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This book represents the first comprehensive compilation of deliberations on botany; genetic resources; genetic diversity analysis; classical genetics & traditional breeding; in vitro culture & genetic transformation; detailed information on molecular maps & mapping of economic genes and QTLs; whole genome sequencing of the nuclear genome and sequencing of chloroplast genome; and elucidation of functional genomics. It also addresses alternate flowering, a unique problem in mango, and discusses currently available genomic resources and databases. Gathering contributions by globally reputed experts, the book will benefit the students, teachers, and scientists in academia and at private companies interested in horticulture, genetics, breeding, pathology, entomology, physiology, molecular genetics and breeding, in vitro culture & genetic engineering, and structural and functional genomics.
Plants are amazing organisms to study, some are important sources for pharmaceuticals, and others can help to elucidate molecular mechanisms required for a plant’s development and its interactions with the biotic or abiotic environment. Functional genomics is vastly lagging behind the speed of genome sequencing as high-throughput gene function assays are difficult to design, specifically for non-model plants. Bioinformatics tools are useful for gene identification and annotation but are of limited value for predictions concerning gene functions as gene functions are uncovered best by experimental approaches. Virus-Induced-Gene-Silencing (VIGS) is an easy to use, fast, and reliable method to achieve down regulation of target gene expression. Virus-Induced Gene Silencing: Methods and Protocols provides detailed protocols for VIGS experiments in several plant species including model and non-model plants. Also included in this book are recently developed protocols for VIGS-derived microRNA production in the plant or protein over expression, as well as chapters devoted to summarizing the molecular mechanisms of VIGS action and the vector systems developed so far. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Virus-Induced Gene Silencing: Methods and Protocols serves as a valuable resource for researchers from diverse fields of plant biology interested in experimental approaches to analyzing gene functions.
Most scholarship on corporate governance in the last two decades has focused on the relationships between shareholders and managers or directors. Neglected in this vast literature is the role of employees in corporate governance. Yet "human capital," embodied in the employees, is rapidly becoming the most important source of value for corporations, and outside the United States, employees often have a significant formal role in corporate governance. This volume turns the spotlight on the neglected role of employees by analyzing many of the formal and informal ways that employees are actually involved in the governance of corporations, in U.S. firms and in large corporations in Germany and Japan. Examining laws and contexts, the essays focus on the framework for understanding employees' role in the firm and the implications for corporate governance. They explore how and why the special legal institutions in German and Japanese firms by which employees are formally involved in corporate governance came into being, and the impact these institutions have on firms and on their ability to compete. They also consider theoretical and empirical questions about employee share ownership. The result of a conference at Columbia University, the volume includes essays by Theodor Baums, Margaret M. Blair, David Charny, Greg Dow, Bernd Frick, Ronald J. Gilson, Jeffrey N. Gordon, Nobuhiro Hiwatari, Katharina Pistor, Louis Putterman, Edward B. Rock, Mark J. Roe, and Michael L. Wachter. Margaret M. Blair is a senior fellow in Economic Studies at the Brookings Institution and author of Ownership and Control: Rethinking Corporate Governance for the Twenty-first Century (Brookings, 1995). Mark J. Roe, professor of business regulation and director of the Sloan Project on Corporate Governance at Columbia Law School, is the author of Strong Managers, Weak Owners: The Political Roots of American Corporate Finance (Princeton, 1996).
Climate change is expected to have a drastic impact on agronomic conditions including temperature, precipitation, soil nutrients, and the incidence of disease pests, to name a few. To face this looming threat, significant progress in developing new breeding strategies has been made over the last few decades. The first volume of Genomics and Breeding for Climate-Resilient Crops presents the basic concepts and strategies for developing climate-resilient crop varieties. Topics covered include: conservation, evaluation and utilization of biodiversity; identification of traits, genes and crops of the future; genomic and molecular tools; genetic engineering; participatory and evolutionary breeding; bioinformatics tools to support breeding; funding and networking support; and intellectual property, regulatory issues, social and political dimensions. ​
A Marginal Revolution Book of the Year After tracking the lives of thousands of people from birth to midlife, four of the world’s preeminent psychologists reveal what they have learned about how humans develop. Does temperament in childhood predict adult personality? What role do parents play in shaping how a child matures? Is day care bad—or good—for children? Does adolescent delinquency forecast a life of crime? Do genes influence success in life? Is health in adulthood shaped by childhood experiences? In search of answers to these and similar questions, four leading psychologists have spent their careers studying thousands of people, observing them as they’ve grown up and grown older. The result is unprecedented insight into what makes each of us who we are. In The Origins of You, Jay Belsky, Avshalom Caspi, Terrie Moffitt, and Richie Poulton share what they have learned about childhood, adolescence, and adulthood, about genes and parenting, and about vulnerability, resilience, and success. The evidence shows that human development is not subject to ironclad laws but instead is a matter of possibilities and probabilities—multiple forces that together determine the direction a life will take. A child’s early years do predict who they will become later in life, but they do so imperfectly. For example, genes and troubled families both play a role in violent male behavior, and, though health and heredity sometimes go hand in hand, childhood adversity and severe bullying in adolescence can affect even physical well-being in midlife. Painstaking and revelatory, the discoveries in The Origins of You promise to help schools, parents, and all people foster well-being and ameliorate or prevent developmental problems.
A concise history of how American law has shaped—and been shaped by—the experience of contagion“Contrarians and the civic-minded alike will find Witt’s legal survey a fascinating resource”—Kirkus, starred review “Professor Witt’s book is an original and thoughtful contribution to the interdisciplinary study of disease and American law. Although he covers the broad sweep of the American experience of epidemics from yellow fever to COVID-19, he is especially timely in his exploration of the legal background to the current disaster of the American response to the coronavirus. A thought-provoking, readable, and important work.”—Frank Snowden, author of Epidemics and Society From yellow fever to smallpox to polio to AIDS to COVID-19, epidemics have prompted Americans to make choices and answer questions about their basic values and their laws. In five concise chapters, historian John Fabian Witt traces the legal history of epidemics, showing how infectious disease has both shaped, and been shaped by, the law. Arguing that throughout American history legal approaches to public health have been liberal for some communities and authoritarian for others, Witt shows us how history’s answers to the major questions brought up by previous epidemics help shape our answers today: What is the relationship between individual liberty and the common good? What is the role of the federal government, and what is the role of the states? Will long-standing traditions of government and law give way to the social imperatives of an epidemic? Will we let the inequities of our mixed tradition continue?
This book celebrates the dawn of the rye genomics era with concise, comprehensive, and accessible reviews on the current state of rye genomic research, written by experts in the field for students, researchers and growers. To most, rye is the key ingredient in a flavoursome bread or their favourite American whisky. To a farmer, rye is the remarkable grain that tolerates the harshest winters and the most unforgiving soils, befitting its legacy as the life-giving seed that fed the ancient civilisations of northern Eurasia. Since the mid-1900s, scientists have employed genetic approaches to better understand and utilize rye, but only since the technological advances of the mid-2010s has the possibility of addressing questions using rye genome assemblies become a reality. Alongside the secret of its unique survival abilities, rye genomics has accelerated research on a host of intriguing topics such as the complex history of rye’s domestication by humans, the nature of genes that switch fertility on and off, the function and origin of accessory chromosomes, and the evolution of selfish DNA.
One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.
The super-rich are silently and secretly shaping our world. In this groundbreaking exploration of historical and contemporary philanthropy, bestselling author Paul Vallelyreveals how this far-reaching change came about. Vivid with anecdote and scholarly insight, this magisterial survey – from the ancient Greeks to today's high-tech geeks – provides an original take on the history of philanthropy. It shows how giving has, variously, been a matter of honour, altruism, religious injunction, political control, moral activism, enlightened self-interest, public good, personal fulfilment and plutocratic manipulation. Its narrative moves from the Greek man of honour and Roman patron, via the Jewish prophet and Christian scholastic – through the Elizabethan machiavel, Puritan proto-capitalist, Enlightenment activist and Victorian moralist – to the robber-baron philanthropist, the welfare socialist, the celebrity activist and today's wealthy mega-giver. In the process it discovers that philanthropy lost an essential element as it entered the modern era. The book then embarks on a journey to determine where today's philanthropists come closest to recovering that missing dimension. Philanthropy explores the successes and failures of philanthrocapitalism, examines its claims and contradictions, and asks tough questions of top philanthropists and leading thinkers – among them Richard Branson, Eliza Manningham-Buller, Jonathan Ruffer, David Sainsbury, John Studzinski, Bob Geldof, Naser Haghamed, Lenny Henry, Jonathan Sacks, Rowan Williams, Ngaire Woods, and the presidents of the Rockefeller and Soros foundations, Rajiv Shah and Patrick Gaspard. In extended conversations they explore the relationship between philanthropy and family, faith, society, art, politics, and the creation and distribution of wealth. Highly engaging and meticulously researched, Paul Vallely's authoritative account of philanthropy then and now critiques the excessive utilitarianism of much modern philanthrocapitalism and points to how philanthropy can rediscover its soul.
In the late summer and fall of 1777, after two years of indecisive fighting on both sides, the outcome of the American War of Independence hung in the balance. Having successfully expelled the Americans from Canada in 1776, the British were determined to end the rebellion the following year and devised what they believed a war-winning strategy, sending General John Burgoyne south to rout the Americans and take Albany. When British forces captured Fort Ticonderoga with unexpected ease in July of 1777, it looked as if it was a matter of time before they would break the rebellion in the North. Less than three and a half months later, however, a combination of the Continental Army and Militia forces, commanded by Major General Horatio Gates and inspired by the heroics of Benedict Arnold, forced Burgoyne to surrender his entire army. The American victory stunned the world and changed the course of the war. Kevin J. Weddle offers the most authoritative history of the Battle of Saratoga to date, explaining with verve and clarity why events unfolded the way they did. In the end, British plans were undone by a combination of distance, geography, logistics, and an underestimation of American leadership and fighting ability. Taking Ticonderoga had misled Burgoyne and his army into thinking victory was assured. Saratoga, which began as a British foraging expedition, turned into a rout. The outcome forced the British to rethink their strategy, inflamed public opinion in England against the war, boosted Patriot morale, and, perhaps most critical of all, led directly to the Franco-American alliance. Weddle unravels the web of contingencies and the play of personalities that ultimately led to what one American general called "the Compleat Victory."