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The concept of photoacoustic tomography (PAT) emerged in the mid-1990s, and the field of PAT is now rapidly moving forward. Presenting the research of a well-respected pioneer and leading expert, Photoacoustic Tomography is a first-of-its-kind book covering the underlying principles and practical applications of PAT in a systematic manner. Written in a tutorial format, the text: Addresses the fundamentals of PAT, the theory on photoacoustic effect, image reconstruction methods, and instrumentation Details advanced methods for quantitative PAT, which allow the recovery of tissue optical absorption coefficient and/or acoustic properties Explores the development of several image-enhancing schemes, including both software and hardware approaches Examines array-based PAT systems that are the foundation for the realization of 2-D, 3-D, and 4-D PAT Discusses photoacoustic microscopy (PAM) and combinations of PAT/PAM with other imaging methods Considers contrast-agents-based molecular PAT, with both nontargeted and cell receptor–targeted methods Describes clinical applications and animal studies in breast cancer detection, osteoarthritis diagnosis, seizure localization, intravascular imaging, and image-guided cancer therapy Photoacoustic Tomography is an essential reference for graduate students, researchers, industry professionals, and those who wish to enter this exciting field.
The second edition of this book offers six new chapters covering the latest developments in quantitative medical imaging, including artificial intelligence, MRI mapping, sonography, elastography and cardiac CT. All the other existing chapters have been updated and expanded, many with new text and figures, to reflect the rapid translation and advancement of technology in this exciting area of biomedical research. This updated edition presents fundamental knowledge on the imaging quantification of biophysical parameters for clinical diagnostic purposes. Clinical imaging scanners are considered by the authors as physical measurement systems capable of quantifying intrinsic parameters for the representation of the constitution and biophysical properties of tissues in vivo. In one respect, this approach fosters the development of new imaging methods for highly reproducible, system-independent, and quantitative biomarkers. These methods are greatly detailed in the book. Alternatively, this new edition equips the reader with a better understanding of how the physical properties of tissues interact with signal generation in medical imaging, opening up new insights into the complex and fascinating relationship between structure and function in living tissues. This updated edition is of interest to all those who recognize the limitations of clinical diagnosis based primarily on visual inspection of images, and who wish to learn more about the diagnostic potential of quantitative, biophysically-based medical imaging markers, as well as the challenges posed by the scarcity of such markers for next-generation imaging technologies.
Gas-phase photoacoustics are treated comprehensively for the first time in this book. Review articles by leading scientists in the respective research areas introduce their fields, review present knowledge and conclude with the latest developments and future prospects. Topics covered include the theory of photoacoustics in the frequency and time domains, acoustic resonator models, a great variety of experimental setups and techniques, studies of spectrocopy and fundamental kinetic processes such as energy transfer and chemical reactions, and applications such as air and exhaust monitoring and trace gas detection in biology and agriculture. The book will interest newcomers to photoacoustics, since it gives an overview of the important directions of current research and detailed descriptions of experimental methods. It will also be a valuable source of information for those already involved in photoacoustic research due to its clear presentation of theory and experimental results. All relevant literature references in this rapidly expanding field of laser applications are included.
This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six times by the authors at Texas A&M University. After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues are covered. The imaging modalities include ballistic imaging, quasi-ballistic imaging (optical coherence tomography), diffusion imaging, and ultrasound-aided hybrid imaging. The basic physics and engineering of each imaging technique are emphasized. A solutions manual is available for instructors; to obtain a copy please email the editorial department at [email protected].
This text should be of interest to students and researchers in photoacoustics in physics, engineering and materials science, and engineers involved in nondestructive testing and metrology. It provides a framework for workers in materials science, physics and chemistry.
Photoacoustics promises to revolutionize medical imaging and may well make as dramatic a contribution to modern medicine as the discovery of the x-ray itself once did. Combining electromagnetic and ultrasonic waves synergistically, photoacoustics can provide deep speckle-free imaging with high electromagnetic contrast at high ultrasonic resolution and without any health risk. While photoacoustic imaging is probably the fastest growing biomedical imaging technology, this book is the first comprehensive volume in this emerging field covering both the physics and the remarkable noninvasive applications that are changing diagnostic medicine. Bringing together the leading pioneers in this field to write about their own work, Photoacoustic Imaging and Spectroscopy is the first to provide a full account of the latest research and developing applications in the area of biomedical photoacoustics. Photoacoustics can provide functional sensing of physiological parameters such as the oxygen saturation of hemoglobin. It can also provide high-contrast functional imaging of angiogenesis and hypermetabolism in tumors in vivo. Discussing these remarkable noninvasive applications and so much more, this reference is essential reading for all researchers in medical imaging and those clinicians working at the cutting-edge of modern biotechnology to develop diagnostic techniques that can save many lives and just as importantly do no harm.
Photoacoustic and Photothermal Spectroscopy: Principles and Applications introduces the basic principles, instrumentation and major developments in the many applications of Photoacoustic and Photothermal Spectroscopy over the last three decades. The book explains the processes of sound generation by periodic optical excitation and ultrasonic generation by pulsed laser excitation and describes the workings of photoacoustic cells equipped with microphones and piezoelectric transducers. Photoacoustic imaging (PAI) is one of the fastest-growing imaging modalities of recent times. It combines the advantages of ultrasound and optical imaging techniques. These non-invasive and non-destructive techniques offer many benefits to users by enabling spectroscopy of opaque and inhomogeneous materials, (solid, liquid, powder, gel, gases) without any sample preparation, and more. - Written in a non-mathematical, simple-to-read manner - Presents recent developments in the field, along with the scope of future progress, including up-to-date references - Includes detailed illustrations, such as equipment layout, spectra, experimental setups, tables, photographs, and more
This book highlights the use of LEDs in biomedical photoacoustic imaging. In chapters written by key opinion leaders in the field, it covers a broad range of topics, including fundamentals, principles, instrumentation, image reconstruction and data/image processing methods, preclinical and clinical applications of LED-based photoacoustic imaging. Apart from preclinical imaging studies and early clinical pilot studies using LED-based photoacoustics, the book includes a chapter exploring the opportunities and challenges of clinical translation from an industry perspective. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging.