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Phenoxypropanolamines: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Phenoxypropanolamines in a concise format. The editors have built Phenoxypropanolamines: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phenoxypropanolamines in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phenoxypropanolamines: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Phenoxypropanolamines—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Phenoxypropanolamines in a concise format. The editors have built Phenoxypropanolamines—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phenoxypropanolamines in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phenoxypropanolamines—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Propanols: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Propanols in a concise format. The editors have built Propanols: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Propanols in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Propanols: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Biogenic Amine Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Biogenic Amine Receptors in a concise format. The editors have built Biogenic Amine Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biogenic Amine Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Biogenic Amine Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. - Continues the legacy of this premier serial with quality chapters on de novo enzyme design - Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field - Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism
Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.
The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals, and how manufacturing should be conducted in an environment that follows Good Manufacturing Practice (GMP) guidelines. Researchers and students will find this book to be a comprehensive resource for those working in, and studying, pharmaceuticals, cosmetics, biotechnology, foods and related industries. Provides an overview of practical information for clinical trials Outlines how to ensure an environment that follows Good Manufacturing Practice (GMP) Examines recent developments and suggests future directions for drug production methods and techniques
In this collection, Unraveled, Emily Regan has spanned the generations, from the very young to the very old, to present characters in the midst of loss. Again and again, her characters' tethers are coming loose, and even breaking, sending some adrift, while others try to find their grasp once more. The losses in some of these stories are devastating because they mostly deal with a loved one's leaving, either intentionally or unintentionally. In our time, to lose something is nothing new: a job, a foreclosed house, or a repossessed car. But Regan delves into how the psyche responds to the real emotional extremes of loss. The death of a loved one is life changing. But when a character simply leaves out of selfishness or self-preservation, abandoning a child out in the yard on a swing set, the ramification can be life destroying.Some of these stories I've read in earlier incarnations and some are new to me, as they will be to the fortunate readers of this collection. "Squirrels" shows a widow becoming undone, heralding the end of her freedom of living alone. Her longing for her dead husband has driven her to attack, in funny and crazed ways, an unseen army of squirrels. She is convinced the squirrels want her out of her house. But her real evictor, her daughter, is more difficult to conquer. In "Visiting Day" we witness a vital elderly woman, who is strong and confident at the start, lose her way. All because the old sometimes have a way of reverting to acting like school children, and the simple action of sitting down at a table can have debilitating consequences. "Mirror, Mirror" is a nice reboot of a fairy tale, but there is no happily ever after for Mariella. The flash fiction, "Five", is one of my favorites in this collection. Regan is pitch-perfect in showing, through actions and dialogue, this emotional moment. A young child's birthday is set aside because of a down deep hurt. And more escapes ensue.In the longest piece in this collection, "Loose Threads", Anne navigates through the coming apart of her family after the death of her brother. Addictions sever the many ties between characters throughout this novella: from drugs, to abusive relationships, to victimization. In the end, though, there comes finally a kind of redemption by way of a baby's birth. Anne is reconnecting with a tether that may bring her back to where she deserves to be.This is Emily Regan's first book. And I'm certain it will not be her last. She has done something here that calls for attention. She has opened familiar wounds that we need to consider, but will not be able to readily heal. And, as many of us may admit, sometimes running away from what hurts us seems the easiest way out. Although, I must acknowledge that Regan, once a student of mine, is now instructing me with her wonderful writing and vivid characters that easiest may work for a moment, but the many moments, days, weeks, and years that follow tend to have a way of making life more and more difficult. Good writing, in my opinion, should present this outcome, and Emily Regan is a very good writer.-- Dan Crawley (from the Preface)
The HMG Chromosomal Proteins focuses on various research on HMG proteins, particularly their association with active genes. Composed of literature of authors that are divided into 10 chapters, the book starts with the discussions on the history and problems in the study of chromosomal proteins. The text proceeds with the discussions on the occurrence of HMG proteins in eukaryotes; tissue specificity of HMG proteins; and species specificity and evolution of HMG proteins. The book presents techniques that are used to analyze HMG proteins and provides information on the primary structures of different proteins, such as HMG 14 and HMG 17, and the methods for cleaving these proteins. The processes involved in isolating proteins and postsynthetic modifications of their structures are noted, clarified with the study done on the HMG proteins of rainbow trout. The text ends with discussions on the association of HMG proteins with chromatin and nucleosomes and a tabulation of accumulated data. This selection is valuable for readers interested in studying HMG proteins.