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The book is intended for chemists entering medicinal chemistry research who have no knowledge of pharmacology. Pharmacological principles and concepts are emphasized, rather than a survey of large numbers of specific drugs. It is intended to serve as a tool to prepare the reader for further in-depth study in many areas of pharmacology.
This textbook explains the key issues in pharmacology to chemists interested in or planning to work in drug discovery.
While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies. The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure–function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines. Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"
There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.
While drug therapies developed in the last 50 years have markedly improved the management of some types of cancers, treatment outcomes, and drug side-effects for the most common types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells.
Written for phytochemists, synthetic chemists, combinatorial chemists, as well as other practitioners and students in related fields, this volume presents cutting-edge research in the chemistry of bioactive natural products and helps the reader understand how natural product research continues to make significant contributions in the discovery a
The first comprehensive resource on the chemistry of vanadium, Vanadium: Chemistry, Biochemistry, Pharmacology, and Practical Applications has evolved from over a quarter century of research that concentrated on delineating the aqueous coordination reactions that characterize the vanadium(V) oxidation state. The authors distill information o
Assuming little previous knowledge of biology, this book aids graduate chemists to close the gap in their knowledge of pharmacology and make the link between medicinal chemistry and the way in which drugs act on the body. The availability of receptor structures has revolutionized drug discovery and development necessitating an up-to-date source of information for chemists entering this new pharmacological world. Chapters, written by experts with an appreciation of most graduate chemists’ knowledge, explain the history of pharmacology, the relationship between receptor structure and function and receptor pharmacology relevant to drug design. Importantly, as drugs are normally discovered in test rather than therapeutic systems, this text describes how pharmacology provides methods to characterize drug activity through scales that allow prediction of drug effect in all systems. Moreover, it outlines the relationship between drug distribution in the body and the action of drugs in particular organ systems relevant to disease. Readers will also find information on pharmacokinetics and drug metabolism, safety pharmacology and toxicology, clinical and regulatory pharmacology and the use of imaging techniques. Carefully edited for relevance to the modern chemist, this unique textbook will be an essential resource for chemists planning to work in drug discovery, or postgraduate students and practicing chemists interested in expanding their pharmacology knowledge
The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. - Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field - Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts - Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research - An image bank is available for instructors at www.textbooks.elsevier.com