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This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion. As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.
Everything you need to know about prescription drugs -- based on the FDA-approved information published in the Physicians' Desk Reference® Why was this drug prescribed for me? What are the benefits and risks of taking this drug? Are there any side effects I should watch for? What questions should I ask my doctor about this prescription? You'll find the answers to all these questions and more in this accessible, up-to-date resource. The drug profiles in this consumer handbook are based on the Physicians' Desk Reference® -- the trusted guide to safe, effective drug therapy that health-care professionals have used for more than 60 years. FEATURES COMPLETELY UPDATED FORMAT THAT MATCHES THE FDA 'S NEWEST REGULATIONS FOR PATIENT INFORMATION
Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments.Key Features* Comprehensive text, covering all aspects of the field of toxicology* Analyzes the importance of toxicokinetics and metabolism as well as cellular targets for the mechanisms of toxic effects* Identifies the various classes of chemical compounds responsible for the toxic effects* Describes the approaches and methods used by various disciplines which investigate toxic effects and their prevention* Adapted from a very successful German text, this edition is completely revised and expanded * The text is well illustrated with diagrams, charts, and tables
Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets. Providing details of state-of-the-art research, Drug Design: Cutting Edge Approaches will be invaluable to all drug discovery scientists, including medicinal and combinatorial chemists, molecular modellers, bio- and chemoinformaticians, and pharmacologists, amongst others. University and pharmaceutical company libraries will also benefit from having a copy on their shelves.
The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen and improve our ability to predict the safety and risks posed by industrial and pharmaceutical chemicals in humans. The reader will find extensive information on the use of current animal models used for various toxicities and target mediated toxicities. Also discussed are the recent regulatory initiatives to improve the safety assessment of chemicals. The book provides an expert and comprehensive discussion on the current status and future directions of predictive toxicology and its application. The various chapters in the book also reflect the growing need for improvements in our technologies and abilities to predict toxicities of pharmaceutical and industrial chemicals to ensure product safety and protect public health.
Written exclusively for limited radiography students, Radiography Essentials for Limited Practice, 5th Edition makes it easy to learn and perform basic procedures. This edition has been revised to improve information clarity and reflect changes in practice. It incorporates all the subjects mandated by the American Society of Radiologic Technologists (ASRT) curriculum, so you will be thoroughly prepared for the ARRT Limited Scope Exam. Coverage includes the latest information on x-ray science and techniques, processing, radiation safety, radiographic anatomy, patient care, and pathology, along with updated step-by-step instructions for positioning and procedures. - Concise coverage thoroughly prepares you for the ARRT Limited Scope Exam and clinical practice with the latest on x-ray science and techniques, radiation safety, radiographic anatomy, pathology, patient care, ancillary clinical skills, and positioning of upper and lower extremities, spine, chest and head. - Step-by-step instructions provide guidance on how to position patients for radiographic procedures performed by limited operators. - The latest information on state licensure and limited radiography terminology ensures that you understand the role of the limited practitioner. - Math and radiologic physics concepts are presented at an easy-to-understand level. - Chapter on Bone Densitometry provides all the information you need to know to for the ARRT exam and clinical practice. - NEW! Expanded digital imaging concepts reflect current practice and meet the requirements of the ASRT Limited Scope Content Specifications. - NEW! Updated drawings, photos, and medical radiographs enhance your understanding of key concepts and illustrate current technology. - NEW! Two-color design helps make complex material easier to comprehend.
Course notes for PASS Program's USMLE Preparation program. Master it...Don't Memorize it!
Each no. represents the results of the FDA research programs for half of the fiscal year.
Wilderness EMS is designed for EMS providers and leaders who deliver medical care in the wilderness, and those practicing wilderness medicine as part of a formal team. The textbook is a comprehensive, expertly-written reference ideal for this fast-changing and multidisciplinary specialty. This first-of-its-kind text provides specialized instruction and best practices for wilderness EMS practitioners and students – crucial information for the success of today’s rescue missions. A strong foundation in evidence-based medicine, clinical experience, and field applicability makes it especially useful for any EMS provider in a wilderness environment.