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''In addition to a wide variety of traditional oxygen transport topics, particular areas have been selected for emphasis at the 1997 meeting, which are: Molecular and genetic techniques to study oxygen transport in health and disease Angiogenesis during hypoxia, ischemia, and development Physiological mechanisms of oxygen sensing Physiological fluctuations of cerebral blood flow, metabolism and oxygenation Near infrared and phsophorescence techniques for the assessment of blood and tissue oxygenation Advances in biotechnology of anticoagulants and blood substitutes. '' (excerpted from the Preface).
This book covers the proceedings of the 32nd scientific meeting of the International Society on Oxygen Transport to Tissue (ISOTT) in Bari, Italy, August 21-26, 2004. It covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. The event hosted was a multidisciplinary meeting designed to bring together experts and students from a range of research fields.
This book contains most of the scientific contributions during the 48th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), which was held electronically in July 2021. It includes multidisciplinary contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians and covers covers all aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence.
Biomedical EPR – Part A focuses on applications of EPR spectroscopy in the areas of free radicals, metals, medicine, and physiology. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field which lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR. Key Features: Free Radicals in Medicine Radicals in vivo and in Model Systems, and their Study by Spin Trapping In vivo EPR, including Oximetry and Imaging Time Domain EPR at Radio Frequencies EPR of Copper Complexes: Motion and Frequency Dependence Time Domain EPR and Electron Spin Echo Envelope Modulation
This book is a compilation of presentations at the first meeting devoted to the mo lecular and cellular biology of copper transport. When we first considered the possible program for the meeting, we felt that a forum to integrate the recent advances in molecular understanding of copper transport with the older knowledge of copper metabolism was needed. In addition we wished to have a strong emphasis on the diseases of copper includ ing the genetic diseases, Menkes and Wilson, and other possible health aspects of this met al seen from a molecular perspective. Overall we were very happy with the success of the meeting, and most participants were very enthusiastic. Unfortunately we were not able to obtain manuscripts from every contributor, but the selection in this book covers most of the topics discussed. The history of biological research into copper dates from the latter half of the last century when the presence of copper as a component of living systems was first noted, but it was not until the 1920s that the essential role of copper was first recognized. l. S. McHargue found that plants and animals needed copper for optimal growth and health and proposed that copper was needed for life (McHargue, 1925). Other groups soon confirmed these observations in plants. In animals the requirement of copper for hematopoiesis was discovered in 1928 (Hart et aI.
The theme of the 1983 annual ISOTT meeting emphasizes a dual scientific approach, utilizing interdisciplinary theoretical and experimental methodology, to unravel the secrets of oxygen transport to tissue. ISOTT is leading the way in the development and application of forefront techniques to allow a more basic understanding of this important physiological phenomena. The Society can be proud of its contributions in helping to advance the gross analysis techniques of the past to the synergistic study of tissue micro areas by sophisticated mathematical and experimental means. There is a tremendous need to continue the pursuit of basic knowledge at the regional tissue level and to move rapidly to the examination of fundamental biochemical reactions at the cellular level. To accomplish this, it will be necessary to take advantage of the most powerful computing machinery presently available and to apply state-of-the-art experimental methodology, such as polarographic, autoradiographic and nuclear magnetic resonance techniques in our studies. Our Society must continue to work hard to push back barriers to enhance our understanding of mechanisms that lead to pathology. Hopefully, our efforts will be significant in helping science to overcome the many dreadful diseases that mankind faces in today's world. Duane Bruley Haim Bicher Daniel Reneau v ACKNOWLEDGEMENT We are forever indebted to Connie Staggs and Ellie Topakoglu for their energy and sacrifice in preparing for and managing the 1983 ISOTT meeting.
This text combines the basic principles and theories of transport in biological systems with fundamental bioengineering. It contains real world applications in drug delivery systems, tissue engineering, and artificial organs. Considerable significance is placed on developing a quantitative understanding of the underlying physical, chemical, and biological phenomena. Therefore, many mathematical methods are developed using compartmental approaches. The book is replete with examples and problems.
This book elucidates the morphological backgrounds of various functional parameters of the human respiratory system, including the respiratory control system, dynamics of the upper and lower airways, gas transport and mixing in the lower airways, gas exchange in the acinus, and gas transfer through the alveolar wall. Presenting the latest findings on the interrelationships between morphology and physiology in the respiratory system, the book’s goal is to provide a foundation for further exploring structure-function relationships in various respiratory systems, and to improve both the quality of basic science, and that of clinical medicine targeting the human respiratory system. Edited and written by internationally recognized experts, Structure-Function Relationships in Various Respiratory Systems offers a valuable asset for all physicians and researchers engaging in clinical, physiological, or morphological work in the field of respiration. Moreover, it provides a practical guide for physicians, helping them make more precise pathophysiological decisions concerning patients with various types of lung disease, and will be of interest to respiratory physiologists and respiratory morphologists.
`In contrast to common practice, we have always tried to include as many discussions held at the meeting in our proceedings as possible, so as to enable readers to properly evaluate each paper presented, as well as to learn of future prospects in this field of research. Although the policy of including discussions occasions a long publication delay, we believe that it is worth repeating in our future publication, as we have met a number of young investigators fascinated by the discussions in our proceedings.... In the concluding remarks in this volume, Dr. Hugh E. Huxley, a principal architect of the sliding filament mechanism of muscle contraction, states that the molecular mechanism of myofilament sliding remains mysterious to all of us. We hope that this volume will stimulate muscle investigators to design and perform novel experiments to clarify the mysteries in muscle contraction.' Haruo Sugi and Gerald H. Pollack, excerpted from the Preface.
This book is a result of the First Conference on Lipoxygenases, held at Malta, May 17th-2l st, 1997. The goal was very ambitious: having lipoxygenases as a focus for distant and diverse experimental approaches, we brought together scientists to discuss and build a consensus on the biological role of lipoxygenases. Although still fuzzy in many details, the Malta conference has shown that a unifying view on lipoxygenases is finally taking shape, and that the experimental evidence of links and conjugations among events OCCUf ing from cell membranes to intracellular compartments and the nucleus is becoming in creasingly convincing. The editors are deeply grateful to Hospital for Sick Children, Toronto, Free Univer sity Berlin, NOAA Sea Grant College Program (U. S. A. ), Schering, Berlin (F. R. G. ), and Cayman Chemicals, Ann Arbor, Michigan (U. S. A. ), for their generous financial support, which was crucial in making the conference a scientific success. The conference received financial support from a number of additional sponsors, and we express our gratitude to Abbott Labs (U. S. A. ), Air Malta (Malta), Ass. Int. Cancer Res. (U. K. ), Biometra (F. R. G. ), Bayer AG (F. R. G. ), IBL Co. (F. R. G. ), Merck Frosst (Canada), Perkin Elmer (F. R. G. ), Scotia Pharmaceuticals (Canada), Searle (U. S. A. ), SPI Chemicals (France), and TOPCRO (Austria).